Home Other Building Blocks 1034616-18-6
1034616-18-6,MFCD26793840
Catalog No.:AA008TFS

1034616-18-6 | Nms-1286937

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
99% (HPLC)
in stock  
$148.00   $104.00
- +
10mg
99% (HPLC)
in stock  
$206.00   $144.00
- +
25mg
99% (HPLC)
in stock  
$364.00   $255.00
- +
50mg
98%
in stock  
$570.00   $399.00
- +
100mg
98%
in stock  
$924.00   $647.00
- +
500mg
99% (HPLC)
in stock  
$2,920.00   $2,044.00
- +
1000mg
99% (HPLC)
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TFS
Chemical Name:
Nms-1286937
CAS Number:
1034616-18-6
Molecular Formula:
C24H27F3N8O3
Molecular Weight:
532.5182
MDL Number:
MFCD26793840
SMILES:
OCCn1nc(c2c1c1nc(ncc1CC2)Nc1cc(ccc1OC(F)(F)F)N1CCN(CC1)C)C(=O)N
Properties
Computed Properties
 
Complexity:
817  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:NERVIANOMEDICALSCIENCESS.R.L.-WO2008/74788,2008,A1Locationinpatent:Page/Pagecolumn103-104

[1]CurrentPatentAssignee:NERVIANOMEDICALSCIENCESS.R.L.-WO2008/74788,2008,A1Locationinpatent:Page/Pagecolumn96

[1]CurrentPatentAssignee:NERVIANOMEDICALSCIENCESS.R.L.-WO2011/12534,2011,A1Locationinpatent:Page/Pagecolumn12

[1]CurrentPatentAssignee:NERVIANOMEDICALSCIENCESS.R.L.-WO2011/12534,2011,A1Locationinpatent:Page/Pagecolumn12

[1]Beria,Italo;Bossi,RobertoT.;Brasca,MariaGabriella;Caruso,Michele;Ceccarelli,Walter;Fachin,Gabriele;Fasolini,Marina;Forte,Barbara;Fiorentini,Francesco;Pesenti,Enrico;Pezzetta,Daniele;Posteri,Helena;Scolaro,Alessandra;Depaolini,StefaniaRe;Valsasina,Barbara[BioorganicandMedicinalChemistryLetters,2011,vol.21,#10,p.2969-2974]

Literature

Title: NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies.

Journal: Molecular cancer therapeutics 20120401

Title: NMS-P937, a 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline derivative as potent and selective Polo-like kinase 1 inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Beria I, et al. NMS-P937, a 4,5-dihydro-1H-pyrazolo,3-hquinazoline derivative as potent and selective Polo-like kinase 1 inhibitor. Bioorg Med Chem Lett. 2011 May 15;21(10):2969-74.

Title: Valsasina B, et al. NMS-P937, an orally available, specific small-molecule polo-like kinase 1 inhibitor with antitumor activity in solid and hematologic malignancies. Mol Cancer Ther. 2012 Apr;11(4):1006-16.

Title: Casolaro A, et al. The Polo-Like Kinase 1 (PLK1) inhibitor NMS-P937 is effective in a new model of disseminated primary CD56+ acute monoblastic leukaemia. PLoS One. 2013;8(3):e58424.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1034616-18-6
Tags:1034616-18-6 Molecular Formula|1034616-18-6 MDL|1034616-18-6 SMILES|1034616-18-6 Nms-1286937