[1]Patent:DE923967,1951,
[1]ChemicalandPharmaceuticalBulletin,1976,vol.24,p.632-643
[1]ArchivderPharmazie,1991,vol.324,p.455-460
[1]JournalofMedicinalChemistry,1985,vol.28,p.1387-1393
Title: Disposition and metabolism of 14C-dovitinib (TKI258), an inhibitor of FGFR and VEGFR, after oral administration in patients with advanced solid tumors.
Journal: Cancer chemotherapy and pharmacology 20121101
Title: Toward rational design of amine solutions for PCC applications: the kinetics of the reaction of CO2(aq) with cyclic and secondary amines in aqueous solution.
Journal: Environmental science & technology 20120703
Title: Simultaneous determination of four plant hormones in bananas by molecularly imprinted solid-phase extraction coupled with high performance liquid chromatography.
Journal: The Analyst 20120621
Title: 5-Methyl-3,3-bis-(4-methyl-piperazin-1-yl)-1-[2-(4-methyl-piperazin-1-yl)eth-yl]indolin-2-one.
Journal: Acta crystallographica. Section E, Structure reports online 20120601
Title: 12-{[4-(2-Fluoro-phen-yl)piperazin-1-yl]-meth-yl}-9α-hy-droxy-4,8-dimethyl-3,14-dioxatricyclo-[9.3.0.0]tetra-dec-7-en-13-one.
Journal: Acta crystallographica. Section E, Structure reports online 20120301
Title: Novel benzothiazole, benzimidazole and benzoxazole derivatives as potential antitumor agents: synthesis and preliminary in vitro biological evaluation.
Journal: Molecules (Basel, Switzerland) 20120117
Title: Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors.
Journal: Journal of medicinal chemistry 20120112
Title: Divalent-metal-stabilized aluminophosphates exhibiting a new zeolite framework topology.
Journal: Inorganic chemistry 20120102
Title: New N-methylpiperazinyl derivatives of bicyclic antiprotozoal compounds.
Journal: European journal of medicinal chemistry 20120101
Title: 2-(5-Fluoro-2,3-dioxoindolin-1-yl)ethyl 4-methyl-piperazine-1-carbodithio-ate.
Journal: Acta crystallographica. Section E, Structure reports online 20120101
Title: Structure and electronic properties of Alq3 derivatives with electron acceptor/donor groups at the C4 positions of the quinolate ligands: a theoretical study.
Journal: Journal of molecular modeling 20111201
Title: (2R)-4-[(9H-Fluoren-9-ylmeth-oxy)carbon-yl]-2-methyl-piperazin-1-ium chloride.
Journal: Acta crystallographica. Section E, Structure reports online 20111201
Title: Polymorphic form IV of olanzapine.
Journal: Acta crystallographica. Section C, Crystal structure communications 20111101
Title: 1-Methyl-piperazine-1,4-diium tetra-chloridozincate hemihydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20111101
Title: 4-(4-Methyl-piperazin-1-yl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)-7-(trifluoro-meth-yl)quinoline.
Journal: Acta crystallographica. Section E, Structure reports online 20111101
Title: Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib.
Journal: Investigational new drugs 20111001
Title: Determination of ofloxacin and lomefloxacin in chicken muscle using molecularly imprinted solid-phase extraction coupled with liquid chromatography.
Journal: Journal of separation science 20111001
Title: N-(4-Chloro-phen-yl)-4-methyl-piperazine-1-carboxamide.
Journal: Acta crystallographica. Section E, Structure reports online 20110901
Title: Bis(1-methyl-piperazine-1,4-diium) tetra-bromidocuprate(II).
Journal: Acta crystallographica. Section E, Structure reports online 20110701
Title: Bis(1-methyl-piperazine-1,4-diium) tetra-chloridocuprate(II).
Journal: Acta crystallographica. Section E, Structure reports online 20110701
Title: Non-peptide NK1 receptor ligands based on the 4-phenylpyridine moiety.
Journal: Bioorganic & medicinal chemistry 20110401
Title: 5-Nitroimidazole-based 1,3,4-thiadiazoles: heterocyclic analogs of metronidazole as anti-Helicobacter pylori agents.
Journal: Archiv der Pharmazie 20110301
Title: Synthesis of 1H-pyrazole-1-carboxamide derivatives and their antiproliferative activity against melanoma cell line.
Journal: Archiv der Pharmazie 20110301
Title: 1-[4-(3-{[5-(4-Chloro-phen-yl)furan-2-yl]methyl-idene-amino}-2,5-dioxoimidazol-idin-1-yl)but-yl]-4-methyl-piperazine-1,4-diium dichloride hemihydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20110201
Title: Critical appraisal of nilotinib in frontline treatment of chronic myeloid leukemia.
Journal: Cancer management and research 20110101
Title: Studies on the anthelmintic property of aminobenzylated mannich bases.
Journal: Journal of young pharmacists : JYP 20110101
Title: Combined pharmacophore modeling, docking, and 3D-QSAR studies of PLK1 inhibitors.
Journal: International journal of molecular sciences 20110101
Title: 3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors.
Journal: International journal of molecular sciences 20110101
Title: Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.
Journal: Bioorganic & medicinal chemistry 20100915
Title: Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors.
Journal: Journal of medicinal chemistry 20100909
Title: In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
Journal: PLoS neglected tropical diseases 20100901
Title: catena-Poly[(S)-2-methyl-piperazine-1,4-diium [[trichloridobismuthate(III)]-di-μ-chlorido]].
Journal: Acta crystallographica. Section E, Structure reports online 20100901
Title: Chalcogenides of the aminomethylphosphines derived from 1-methylpiperazine, 1-ethylpiperazine and morpholine: NMR, DFT and structural studies for determination of electronic and steric properties of the phosphines.
Journal: Dalton transactions (Cambridge, England : 2003) 20100828
Title: Determination of individual proton affinities of ofloxacin from its UV-Vis absorption, fluorescence and charge-transfer spectra: effect of inclusion in beta-cyclodextrin on the proton affinities.
Journal: The journal of physical chemistry. B 20100805
Title: Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
Journal: PLoS neglected tropical diseases 20100601
Title: Streamlined, automated protocols for the production of milligram quantities of untagged recombinant human cyclophilin-A (hCypA) and untagged human proliferating cell nuclear antigen (hPCNA) using AKTAxpress.
Journal: Protein expression and purification 20100501
Title: A statistics-based platform for quantitative N-terminome analysis and identification of protease cleavage products.
Journal: Molecular & cellular proteomics : MCP 20100501
Title: Synthesis and antimicrobial activities of some new 1,2,3-triazole derivatives.
Journal: Molecules (Basel, Switzerland) 20100408
Title: Conjugate addition of nucleophiles to the vinyl function of 2-chloro-4-vinylpyrimidine derivatives.
Journal: Molecules (Basel, Switzerland) 20100319
Title: Detection of nitric oxide in tissue samples by ESI-MS.
Journal: The Analyst 20100201
Title: Sulfonamide-1,2,4-thiadiazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and conformational studies.
Journal: Chemical & pharmaceutical bulletin 20100201
Title: Imatinibium dipicrate.
Journal: Acta crystallographica. Section E, Structure reports online 20100201
Title: Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20100128
Title: Theoretical and experimental studies of the isomeric protonation in solution for a prototype aliphatic ring containing two nitrogens.
Journal: The journal of physical chemistry. B 20100114
Title: Novel imatinib derivatives with altered specificity between Bcr-Abl and FMS, KIT, and PDGF receptors.
Journal: ChemMedChem 20100101
Title: [Synthesis, modifications, and antimicrobial activity of the methylpiperazinyl amides of triterpenic acids].
Journal: Bioorganicheskaia khimiia 20100101
Title: [Synthesis and pharmacological activity of amides and ozonolysis product of maleopimaric acid].
Journal: Bioorganicheskaia khimiia 20100101
Title: Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex.
Journal: Biochemistry 20091229
Title: [2-(4-Methyl-piperazin-1-ylmeth-yl)phen-yl]diphenyl-phosphane.
Journal: Acta crystallographica. Section E, Structure reports online 20091201
Title: Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.
Journal: European journal of medicinal chemistry 20090901
Title: Synthesis of some new 1,3,4-thiadiazol-2-ylmethyl-1,2,4-triazole derivatives and investigation of their antimicrobial activities.
Journal: European journal of medicinal chemistry 20090701
Title: Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay.
Journal: Bioorganic & medicinal chemistry letters 20090515
Title: Manipulation of fluorescent and colorimetric changes of fluorescein derivatives and applications for sensing silver ions.
Journal: Chemical communications (Cambridge, England) 20090314
Title: Synthesis of some new 1,2,4-triazoles, their Mannich and Schiff bases and evaluation of their antimicrobial activities.
Journal: European journal of medicinal chemistry 20090301
Title: Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: antimicrobial, analgesic and antipyretic studies.
Journal: European journal of medicinal chemistry 20090201
Title: Structure elucidation of thioketone analogues of sildenafil detected as adulterants in herbal aphrodisiacs.
Journal: Journal of pharmaceutical and biomedical analysis 20090115
Title: Hoechst 33342: the dye that enabled differentiation of living X-and Y-chromosome bearing mammalian sperm.
Journal: Theriogenology 20090101
Title: The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2).
Journal: BMC structural biology 20090101
Title: The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.
Journal: Nuclear receptor signaling 20090101
Title: Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.
Journal: PloS one 20090101
Title: Nilotinib: optimal therapy for patients with chronic myeloid leukemia and resistance or intolerance to imatinib.
Journal: Drug design, development and therapy 20090101
Title: Proteomics: challenges, techniques and possibilities to overcome biological sample complexity.
Journal: Human genomics and proteomics : HGP 20090101
Title: Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.
Journal: Journal of medicinal chemistry 20081023
Title: Copper(I) cyanide networks: synthesis, structure, and luminescence behavior. Part 2. Piperazine ligands and hexamethylenetetramine.
Journal: Inorganic chemistry 20080804
Title: Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.
Journal: ChemMedChem 20080701
Title: Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.
Journal: Nature chemical biology 20080601
Title: 3-(4-Methyl-piperazin-1-yl)isobenzofuran-1(3H)-one.
Journal: Acta crystallographica. Section E, Structure reports online 20080501
Title: Morpholine-based immonium and halogenoamidinium salts as coupling reagents in Peptide synthesis1.
Journal: The Journal of organic chemistry 20080404
Title: Determination of analogs of sildenafil and vardenafil in foods by column liquid chromatography with a photodiode array detector, mass spectrometry, and nuclear magnetic resonance spectrometry.
Journal: Journal of AOAC International 20080101
Title: Improved proteome coverage by using iTRAQ labelling and peptide OFFGEL fractionation.
Journal: Proteome science 20080101
Title: Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation.
Journal: PloS one 20080101
Title: Development and targeted use of nilotinib in chronic myeloid leukemia.
Journal: Drug design, development and therapy 20080101
Title: Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates.
Journal: Indian journal of pharmaceutical sciences 20080101
Title: Refining targeted therapies in chronic myeloid leukemia: development and application of nilotinib, a step beyond imatinib.
Journal: OncoTargets and therapy 20080101
Title: N-Methyl-piperazinediium penta-chloridoanti-monate(III) monohydrate.
Journal: Acta crystallographica. Section E, Structure reports online 20080101
Title: Use of liquid chromatography-mass spectrometry and a chemical cleavage reaction for the structure elucidation of a new sildenafil analogue detected as an adulterant in an herbal dietary supplement.
Journal: Journal of pharmaceutical and biomedical analysis 20070815
Title: Synthesis of o-sulfamidotriazobenzenes from 1,1'-sulfonylbis(benzotriazole).
Journal: The Journal of organic chemistry 20070720
Title: DFT and ab initio calculations of the vibrational frequencies and visible spectra of triazenes derived from cyclic amines.
Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070601
Title: Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization.
Journal: Bioorganic & medicinal chemistry letters 20070515
Title: Structure elucidation of a novel analogue of sildenafil detected as an adulterant in an herbal dietary supplement.
Journal: Journal of pharmaceutical and biomedical analysis 20070411
Title: Structure determination of new analogues of vardenafil and sildenafil in dietary supplements.
Journal: Food additives and contaminants 20070201
Title: Array-based split-pool combinatorial screening of potential catalysts.
Journal: Journal of combinatorial chemistry 20070101
Title: Precise protein quantification based on peptide quantification using iTRAQ.
Journal: BMC bioinformatics 20070101
Title: NS-187 (INNO-406), a Bcr-Abl/Lyn dual tyrosine kinase inhibitor.
Journal: Analytical chemistry insights 20070101
Title: Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue.
Journal: Bioorganic & medicinal chemistry 20061201
Title: Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: various DNA binding geometry and interesting antitumor capacity.
Journal: Bioorganic & medicinal chemistry 20061015
Title: 7-(aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: addition of water solubilizing groups.
Journal: Bioorganic & medicinal chemistry letters 20060801
Title: Photoaddition of N-substituted piperazines to C60: an efficient approach to the synthesis of water-soluble fullerene derivatives.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060717
Title: Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents.
Journal: American journal of therapeutics 20060101
Title: Synthesis and characterization of water-soluble phenylene-vinylene-based singlet oxygen sensitizers for two-photon excitation.
Journal: The Journal of organic chemistry 20050902
Title: Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.
Journal: Molecular endocrinology (Baltimore, Md.) 20050501
Title: Analysis of cell membrane aminophospholipids as isotope-tagged derivatives.
Journal: Journal of lipid research 20050501
Title: Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification.
Journal: Bioorganic & medicinal chemistry letters 20050315
Title: Identification of 4-methylspinaceamine--a Pictet-Spengler condensation reaction product of histamine with acetaldehyde--in human urine.
Journal: Life sciences 20050128
Title: N-Chloroacyl-6-O-triphenylmethylchitosans: useful intermediates for synthetic modifications of chitosan.
Journal: Biomacromolecules 20050101
Title: Structure determination of a sildenafil analogue contained in commercial herb drinks.
Journal: Magnetic resonance in chemistry : MRC 20041201
Title: 1-Methylpiperazine-1,4-diium 4-nitrophthalate(2-) 4-nitrophthalic acid monohydrate.
Journal: Acta crystallographica. Section C, Crystal structure communications 20040901
Title: Solid-phase synthesis and evaluation of libraries of substituted 4,5-dihydropyridazinones as vasodilator agents.
Journal: The Journal of pharmacy and pharmacology 20040801
Title: Structure elucidation of sildenafil analogues in herbal products.
Journal: Food additives and contaminants 20040801
Title: DNA binding to guide the development of tetrahydroindeno[1,2-b]pyrido[4,3,2-de]quinoline derivatives as cytotoxic agents.
Journal: Journal of medicinal chemistry 20040701
Title: Isoelectric point separation of proteins by capillary pH-gradient ion-exchange chromatography.
Journal: Journal of chromatography. A 20040206
Title: DNA-directed alkylating agents: synthesis, antitumor activity and DNA affinity of bis-N,N'-trisubstituted 1,2,4-triazolo-piperazines.
Journal: Farmaco (Societa chimica italiana : 1989) 20040101
Title: [New derivatives of triazino- and imidazoindole with hepatoprotective activity].
Journal: Biomeditsinskaia khimiia 20040101
Title: Physicochemical determinants for drug induced blockade of HERG potassium channels: effect of charge and charge shielding.
Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20031001
Title: Solid-phase parallel synthesis of 17alpha-substituted estradiol sulfamate and phenol libraries using the multidetachable sulfamate linker.
Journal: Journal of combinatorial chemistry 20030101
Title: Mechanistic insights into the Pd(BINAP)-catalyzed amination of aryl bromides: kinetic studies under synthetically relevant conditions.
Journal: Journal of the American Chemical Society 20021127
Title: New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors.
Journal: Journal of medicinal chemistry 20021107
Title: 2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356.
Journal: Bioorganic & medicinal chemistry letters 20020805
Title: NMR characterization of the DNA binding properties of a novel Hoechst 33258 analogue peptide building block.
Journal: Bioconjugate chemistry 20020101
Title: The interaction of 2-phenylbenzimidazole compounds with DNA: the influence of terminal substituents.
Journal: Nucleic acids research. Supplement (2001) 20020101
Title: Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.
Journal: Journal of medicinal chemistry 20011108
Title: Tris-benzimidazole derivatives: design, synthesis and DNA sequence recognition.
Journal: Bioorganic & medicinal chemistry 20011101
Title: Tertiary N-glucuronides of clozapine and its metabolite desmethylclozapine in patient urine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20011001
Title: Ofloxacin/beta-cyclodextrin complexation.
Journal: Drug development and industrial pharmacy 20010701
1-Methylpiperazine is a chemical compound utilized in various synthetic methodologies, particularly in the preparation of specialized materials. Its significance is evident in its role as a mimic template in the synthesis of molecularly imprinted microspheres (MIMs), which are tailored for selective molecular recognition applications. Additionally, 1-Methylpiperazine is employed in the preparation of difunctional strong anion-exchange stationary phases derived from 1,4-diazacyclohexane derivatives. This versatile compound serves as a key building block in the synthesis of specialized materials with tailored properties for chromatographic separations and molecular recognition applications.
