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1109276-89-2,MFCD19443642
Catalog No.:AA008TG6

1109276-89-2 | Pf-04620110

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Purity
Availability
Price(USD)
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5mg
≥98%
in stock  
$132.00   $92.00
- +
10mg
≥98%
in stock  
$222.00   $155.00
- +
25mg
≥98%
in stock  
$515.00   $360.00
- +
50mg
99%
in stock  
$820.00   $574.00
- +
100mg
99%
in stock  
$1,436.00   $1,005.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TG6
Chemical Name:
Pf-04620110
CAS Number:
1109276-89-2
Molecular Formula:
C21H24N4O4
Molecular Weight:
396.4397
MDL Number:
MFCD19443642
SMILES:
OC(=O)CC1CCC(CC1)c1ccc(cc1)N1CCOc2c(C1=O)c(N)ncn2
Properties
Computed Properties
 
Complexity:
587  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3.3  

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-US2009/36425,2009,A1Locationinpatent:Page/Pagecolumn22

[1]Locationinpatent:schemeortableDow,RobertL.;Li,Jian-Cheng;Pence,MichaelP.;Gibbs,E.Michael;Laperle,JenniferL.;Litchfield,John;Piotrowski,DavidW.;Munchhof,MichaelJ.;Manion,TaraB.;Zavadoski,WilliamJ.;Walker,GregoryS.;McPherson,R.Kirk;Tapley,Susan;Sugarman,Eliot;Guzman-Perez,Angel;Dasilva-Jardine,Paul[ACSMedicinalChemistryLetters,2011,vol.2,#5,p.407-412]

[2]CurrentPatentAssignee:PFIZERINC-US2009/36425,2009,A1Locationinpatent:Page/Pagecolumn18-19

[3]CurrentPatentAssignee:PFIZERINC-WO2010/86820,2010,A1Locationinpatent:Page/Pagecolumn35-36

[1]CurrentPatentAssignee:PFIZERINC-WO2010/86820,2010,A1Locationinpatent:Page/Pagecolumn83-84

[2]Dow,RobertL.;Andrews,MelissaP.;Li,Jian-Cheng;MichaelGibbs;Guzman-Perez,Angel;Laperle,JenniferL.;Li,Qifang;Mather,Dawn;Munchhof,MichaelJ.;Niosi,Mark;Patel,Leena;Perreault,Christian;Tapley,Susan;Zavadoski,WilliamJ.[BioorganicandMedicinalChemistry,2013,vol.21,#17,p.5081-5097]

[1]CurrentPatentAssignee:PFIZERINC-WO2010/86820,2010,A1Locationinpatent:Page/Pagecolumn79-80

[2]Dow,RobertL.;Andrews,MelissaP.;Li,Jian-Cheng;MichaelGibbs;Guzman-Perez,Angel;Laperle,JenniferL.;Li,Qifang;Mather,Dawn;Munchhof,MichaelJ.;Niosi,Mark;Patel,Leena;Perreault,Christian;Tapley,Susan;Zavadoski,WilliamJ.[BioorganicandMedicinalChemistry,2013,vol.21,#17,p.5081-5097]

[1]CurrentPatentAssignee:PFIZERINC-WO2010/86820,2010,A1Locationinpatent:Page/Pagecolumn81-82

Literature

Title: Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core.

Journal: Bioorganic & medicinal chemistry letters 20111015

Title: Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.

Journal: ACS medicinal chemistry letters 20110512

Title: Dow RL, et al. Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino,3-dpyrimidine core. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6122-5.

Title: Dow RL, et al. Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1. ACS Med Chem Lett. 2011 Mar 18;2(5):407-12.

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