Home Other Building Blocks 114432-13-2
114432-13-2,MFCD00867144
Catalog No.:AA008YVT

114432-13-2 | Fantofarone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
98%
in stock  
$184.00   $129.00
- +
10mg
98%
in stock  
$272.00   $190.00
- +
25mg
98%
in stock  
$477.00   $334.00
- +
50mg
98%
in stock  
$752.00   $527.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008YVT
Chemical Name:
Fantofarone
CAS Number:
114432-13-2
Molecular Formula:
C31H38N2O5S
Molecular Weight:
550.7088
MDL Number:
MFCD00867144
SMILES:
COc1cc(CCN(CCCOc2ccc(cc2)S(=O)(=O)c2c(cn3c2cccc3)C(C)C)C)ccc1OC
Properties
Computed Properties
 
Complexity:
825  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
13  
XLogP3:
6.7  

Literature

Title: (7R,8S,8aS)-8-Hydr-oxy-7-phenyl-perhydro-indolizin-3-one.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

Title: Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis.

Journal: Apoptosis : an international journal on programmed cell death 20070901

Title: De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis.

Journal: Journal of leukocyte biology 20070601

Title: Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.

Journal: The FEBS journal 20070601

Title: SR33805, a Ca2+ antagonist with length-dependent Ca2+ -sensitizing properties in cardiac myocytes.

Journal: British journal of pharmacology 20030501

Title: Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells.

Journal: Experimental cell research 20020215

Title: SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.

Journal: The Journal of pharmacology and experimental therapeutics 19901101

Title: Adovelande J, et al. Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochem Pharmacol. 1998 Feb 15;55(4):433-40.

Title: Dongay B, et al. Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model. Biochem Pharmacol. 1998 Jun 15;55(12):2047-50.

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