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Home Other Building Blocks 1346572-63-1
1346572-63-1,MFCD28405142
Catalog No.:AA009BMI

1346572-63-1 | Gsk503

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$199.00   $139.00
- +
10mg
98%
in stock  
$304.00   $213.00
- +
25mg
98%
in stock  
$613.00   $429.00
- +
50mg
98%
in stock  
$924.00   $647.00
- +
100mg
98%
in stock  
$1,436.00   $1,005.00
- +
500mg
98% by HPLC
in stock  
$7,073.00   $4,951.00
- +
1000mg
98% by HPLC
in stock  
$11,279.00   $7,896.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009BMI
Chemical Name:
Gsk503
CAS Number:
1346572-63-1
Molecular Formula:
C31H38N6O2
Molecular Weight:
526.6724
MDL Number:
MFCD28405142
SMILES:
CN1CCN(CC1)c1ccc(cn1)c1cc(C(=O)NCc2c(C)cc([nH]c2=O)C)c2c(c1)n(cc2C)C(C)C
Properties
Computed Properties
 
Complexity:
984  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
3.8  

Upstream Synthesis Route

[1]Patent:WO2011/140324,2011,A1,.Locationinpatent:Page/Pagecolumn79-80

[2]Patent:US2014/256739,2014,A1,.Locationinpatent:Paragraph0556

Downstream Synthesis Route

[1]Patent:WO2011/140324,2011,A1.Locationinpatent:Page/Pagecolumn79-80

[2]Patent:US2014/256739,2014,A1.Locationinpatent:Paragraph0556

Literature

Title: Béguelin W, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell. 2013 May 13;23(5):677-92.

Title: Zingg D, et al. The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors. Nat Commun. 2015 Jan 22;6:6051.

Quotation Request
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SDS
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Tags:1346572-63-1 Molecular Formula|1346572-63-1 MDL|1346572-63-1 SMILES|1346572-63-1 Gsk503