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Home Other Building Blocks 1346574-57-9
1346574-57-9,MFCD23381067
Catalog No.:AA009C97

1346574-57-9 | Gsk126

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$37.00   $26.00
- +
100mg
98%
in stock  
$231.00   $162.00
- +
250mg
98%
in stock  
$368.00   $258.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009C97
Chemical Name:
Gsk126
CAS Number:
1346574-57-9
Molecular Formula:
C31H38N6O2
Molecular Weight:
526.6724
MDL Number:
MFCD23381067
SMILES:
CC[C@@H](n1cc(c2c1cc(cc2C(=O)NCc1c(C)cc([nH]c1=O)C)c1ccc(nc1)N1CCNCC1)C)C
Properties
Computed Properties
 
Complexity:
972  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
3.9  

Literature

Title: Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2.

Journal: The Journal of biological chemistry 20151113

Title: EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations.

Journal: Nature 20121206

Title: Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens.

Journal: Journal of biomolecular screening 20121201

Title: McCabe MT, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012 Dec 6;492(7427):108-12.

Title: Sato T, et al. PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer. Sci Rep. 2013 May 29;3:1911.

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SDS
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Tags:1346574-57-9 Molecular Formula|1346574-57-9 MDL|1346574-57-9 SMILES|1346574-57-9 Gsk126