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1346704-33-3,MFCD25563250
Catalog No.:AA009C9D

1346704-33-3 | Gsk343

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$25.00   $18.00
- +
5mg
98%
in stock  
$44.00   $31.00
- +
10mg
98%
in stock  
$71.00   $50.00
- +
25mg
98%
in stock  
$126.00   $89.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009C9D
Chemical Name:
Gsk343
CAS Number:
1346704-33-3
Molecular Formula:
C31H39N7O2
Molecular Weight:
541.6871
MDL Number:
MFCD25563250
SMILES:
CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2c1cnn2C(C)C)c1ccnc(c1)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
986  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
4  

Upstream Synthesis Route

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

Downstream Synthesis Route

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.1091-1096

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.1091-1096

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.1091-1096

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.1091-1096

Literature

Title: Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

Journal: Nature communications 20140101

Title: Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition.

Journal: Cell cycle (Georgetown, Tex.) 20130701

Title: Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

Journal: ACS medicinal chemistry letters 20121213

Title: Sharad K, et al. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6.

Title: Ding M, et al. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer. Clin Exp Pharmacol Physiol. 2015 May;42(5):458-64.

Quotation Request
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SDS
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Tags:1346704-33-3 Molecular Formula|1346704-33-3 MDL|1346704-33-3 SMILES|1346704-33-3 Gsk343
Catalog No.: AA009C9D
1346704-33-3,MFCD25563250
1346704-33-3 | Gsk343
Pack Size： 1mg
Purity： 98%
in stock
$25.00 $18.00
Pack Size： 5mg
Purity： 98%
in stock
$44.00 $31.00
Pack Size： 10mg
Purity： 98%
in stock
$71.00 $50.00
Pack Size： 25mg
Purity： 98%
in stock
$126.00 $89.00
Quantity
- +
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Technical Information
Catalog Number: AA009C9D
Chemical Name: Gsk343
CAS Number: 1346704-33-3
Molecular Formula: C31H39N7O2
Molecular Weight: 541.6871
MDL Number: MFCD25563250
SMILES: CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2c1cnn2C(C)C)c1ccnc(c1)N1CCN(CC1)C
Properties
Complexity: 986  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 40  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 8  
XLogP3: 4  
Upstream Synthesis Route
832114-09-7    1346702-61-1    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

1346702-54-2    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

1346575-64-1    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

5609-09-6    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

1346702-52-0    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,#12,p.1091-1096

Downstream Synthesis Route
1346702-54-2    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.1091-1096

832114-09-7    1346702-61-1    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.1091-1096

1346575-64-1    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.1091-1096

5609-09-6    1346704-33-3 

[1]ACSMedicinalChemistryLetters,2012,vol.3,p.1091-1096

Literature fold

Title: Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

Journal: Nature communications20140101

Title: Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibition.

Journal: Cell cycle (Georgetown, Tex.)20130701

Title: Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.

Journal: ACS medicinal chemistry letters20121213

Title: Sharad K, et al. Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett. 2012 Oct 19;3(12):1091-6.

Title: Ding M, et al. The polycomb group protein enhancer of zeste 2 is a novel therapeutic target for cervical cancer. Clin Exp Pharmacol Physiol. 2015 May;42(5):458-64.

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