131875-08-6,MFCD00867078
Catalog No.:AA009C9X

131875-08-6 | Lexacalcitol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99%
1 week  
$606.00   $424.00
- +
5mg
99%
1 week  
$1,320.00   $924.00
- +
10mg
99%
1 week  
$2,035.00   $1,424.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009C9X
Chemical Name:
Lexacalcitol
CAS Number:
131875-08-6
Molecular Formula:
C29H48O4
Molecular Weight:
460.6890
MDL Number:
MFCD00867078
SMILES:
CCC(CCCO[C@@H]([C@H]1CC[C@@H]2[C@]1(C)CCC/C/2=C\C=C/1\C[C@@H](O)C[C@@H](C1=C)O)C)(CC)O
Properties
Computed Properties
 
Complexity:
734  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
2  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
4.9  

Literature

Title: Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action.

Journal: Laboratory investigation; a journal of technical methods and pathology 20110101

Title: Synergistic induction of gene expression during the differentiation into mature macrophage in human myeloblastic leukemia cells treated with TPA and KH1060.

Journal: Leukemia research 20090601

Title: Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo.

Journal: Endocrinology 20080701

Title: Interaction among vitamin D(3) analogue KH 1060, TNF-alpha, and vitamin D receptor protein in peripheral blood mononuclear cells of inflammatory bowel disease patients.

Journal: International immunopharmacology 20060701

Title: Vitamin D receptor: ligand recognition and allosteric network.

Journal: Journal of medicinal chemistry 20060223

Title: Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050701

Title: Biochemical effects of KH 1060 and anti-TNF monoclonal antibody on human peripheral blood mononuclear cells.

Journal: International immunopharmacology 20050401

Title: Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target.

Journal: Journal of medicinal chemistry 20041230

Title: 9-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid X receptor in human osteoblastic cells.

Journal: Journal of cellular biochemistry 20030815

Title: Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein.

Journal: Biochemical pharmacology 20030801

Title: 1,25-dihydroxyvitamin D3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax.

Journal: Experimental eye research 20030701

Title: Anti-proliferative effects of 20-epi-vitamin-D3 analogue, KH1060 in human neuroblastoma: induction of RAR-beta and p21(Cip1).

Journal: Cancer letters 20030210

Title: Involvement of diverse protein kinase C isoforms in the differentiation of ML-1 human myeloblastic leukemia cells induced by the vitamin D3 analogue KH1060 and the phorbol ester TPA.

Journal: Cancer letters 20021201

Title: Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.

Journal: The American journal of gastroenterology 20020301

Title: Synergistic effect of vitamin D derivatives and retinoids on C2C12 skeletal muscle cells.

Journal: IUBMB life 20020301

Title: A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice.

Journal: Transplantation proceedings 20010501

Title: Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC.

Journal: Clinical immunology (Orlando, Fla.) 20010401

Title: Suppressive effect of 1,25-dihydroxyvitamin D3 and its analogues EB 1089 and KH 1060 on T lymphocyte proliferation in active ulcerative colitis.

Journal: Biochemical pharmacology 20010201

Title: Cytotoxic effects of 1 alpha,25-dihydroxyvitamin D3 and synthetic vitamin D3 analogues on a glioma cell line.

Journal: Cancer letters 19960227

Title: Studies on two new vitamin D analogs, EB 1089 and KH 1060: effects on bone resorption and osteoclast recruitment in vitro.

Journal: Bone 19951001

Title: L Binderup, et al. 20-epi-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol. 1991 Sep 27;42(8):1569-75.

Title: C Gysemans, et al. A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc. 2001 May;33(3):2365.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:131875-08-6 Molecular Formula|131875-08-6 MDL|131875-08-6 SMILES|131875-08-6 Lexacalcitol
Catalog No.: AA009C9X
131875-08-6,MFCD00867078
131875-08-6 | Lexacalcitol
Pack Size: 1mg
Purity: 99%
1 week
$606.00 $424.00
Pack Size: 5mg
Purity: 99%
1 week
$1,320.00 $924.00
Pack Size: 10mg
Purity: 99%
1 week
$2,035.00 $1,424.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA009C9X
Chemical Name: Lexacalcitol
CAS Number: 131875-08-6
Molecular Formula: C29H48O4
Molecular Weight: 460.6890
MDL Number: MFCD00867078
SMILES: CCC(CCCO[C@@H]([C@H]1CC[C@@H]2[C@]1(C)CCC/C/2=C\C=C/1\C[C@@H](O)C[C@@H](C1=C)O)C)(CC)O
Properties
Complexity: 734  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 6  
Defined Bond Stereocenter Count: 2  
Heavy Atom Count: 33  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 9  
XLogP3: 4.9  
Literature fold

Title: Vitamin D inhibits CEACAM1 to promote insulin/IGF-I receptor signaling without compromising anti-proliferative action.

Journal: Laboratory investigation; a journal of technical methods and pathology20110101

Title: Synergistic induction of gene expression during the differentiation into mature macrophage in human myeloblastic leukemia cells treated with TPA and KH1060.

Journal: Leukemia research20090601

Title: Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo.

Journal: Endocrinology20080701

Title: Interaction among vitamin D(3) analogue KH 1060, TNF-alpha, and vitamin D receptor protein in peripheral blood mononuclear cells of inflammatory bowel disease patients.

Journal: International immunopharmacology20060701

Title: Vitamin D receptor: ligand recognition and allosteric network.

Journal: Journal of medicinal chemistry20060223

Title: Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20050701

Title: Biochemical effects of KH 1060 and anti-TNF monoclonal antibody on human peripheral blood mononuclear cells.

Journal: International immunopharmacology20050401

Title: Targacept active conformation search: a new method for predicting the conformation of a ligand bound to its protein target.

Journal: Journal of medicinal chemistry20041230

Title: 9-cis retinoic acid accelerates calcitriol-induced osteocalcin production and promotes degradation of both vitamin D receptor and retinoid X receptor in human osteoblastic cells.

Journal: Journal of cellular biochemistry20030815

Title: Inhibition of MG-63 cell cycle progression by synthetic vitamin D3 analogs mediated by p27, Cdk2, cyclin E, and the retinoblastoma protein.

Journal: Biochemical pharmacology20030801

Title: 1,25-dihydroxyvitamin D3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax.

Journal: Experimental eye research20030701

Title: Anti-proliferative effects of 20-epi-vitamin-D3 analogue, KH1060 in human neuroblastoma: induction of RAR-beta and p21(Cip1).

Journal: Cancer letters20030210

Title: Involvement of diverse protein kinase C isoforms in the differentiation of ML-1 human myeloblastic leukemia cells induced by the vitamin D3 analogue KH1060 and the phorbol ester TPA.

Journal: Cancer letters20021201

Title: Synergistic inhibitory effect of cyclosporin A and vitamin D derivatives on T-lymphocyte proliferation in active ulcerative colitis.

Journal: The American journal of gastroenterology20020301

Title: Synergistic effect of vitamin D derivatives and retinoids on C2C12 skeletal muscle cells.

Journal: IUBMB life20020301

Title: A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice.

Journal: Transplantation proceedings20010501

Title: Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC.

Journal: Clinical immunology (Orlando, Fla.)20010401

Title: Suppressive effect of 1,25-dihydroxyvitamin D3 and its analogues EB 1089 and KH 1060 on T lymphocyte proliferation in active ulcerative colitis.

Journal: Biochemical pharmacology20010201

Title: Cytotoxic effects of 1 alpha,25-dihydroxyvitamin D3 and synthetic vitamin D3 analogues on a glioma cell line.

Journal: Cancer letters19960227

Title: Studies on two new vitamin D analogs, EB 1089 and KH 1060: effects on bone resorption and osteoclast recruitment in vitro.

Journal: Bone19951001

Title: L Binderup, et al. 20-epi-vitamin D3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol. 1991 Sep 27;42(8):1569-75.

Title: C Gysemans, et al. A combination of KH1060, a vitamin D(3) analogue, and cyclosporin prevents early graft failure and prolongs graft survival of xenogeneic islets in nonobese diabetic mice. Transplant Proc. 2001 May;33(3):2365.

Building Blocks More >
1345823-20-2
1345823-20-2
Cy5-yne
AA009CES | MFCD29472577
1235034-55-5
1235034-55-5
A-1155463
AA009CI3 | MFCD29924714
1255517-77-1
1255517-77-1
UNC 0638
AA009CQS | MFCD17215972
122375-83-1
122375-83-1
1-Bromo-2-chloro-3,4,5-trifluorobenzene
AA009D8D | MFCD00070736
13360-78-6
13360-78-6
SODIUM DI(ISOBUTYL)DITHIOPHOSPHINATE
AA009DDT | MFCD00216697
1227465-66-8
1227465-66-8
5-Cyclopropyl-1,3,4-oxadiazol-2-ol
AA009DPQ | MFCD16556135
1227465-74-8
1227465-74-8
9-Ethyl-2,9-diazaspiro[5.5]undecane
AA009DVW | MFCD16556125
121513-38-0
121513-38-0
3-[2-[(2,3,4,5,6-2H5)Phenyl]propyl]-4-hydroxy-2H-1-benzopyran-2-one
AA009E2M
1219803-58-3
1219803-58-3
CitalopraM-d4 HydrobroMide Salt
AA009E9G | MFCD11977974
1276500-47-0
1276500-47-0
Tris(2-chloroethyl)phosphate-d12
AA009EHU | MFCD20257118
Submit
© 2017 AA BLOCKS, INC. All rights reserved.