104121-92-8,MFCD25977156
Catalog No.:AA008TCY

104121-92-8 | 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

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Purity
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Quantity
  
1mg
≥98%
in stock  
$179.00   $125.00
- +
5mg
≥98%
in stock  
$805.00   $563.00
- +
10mg
≥98%
in stock  
$1,340.00   $938.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TCY
Chemical Name:
2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
CAS Number:
104121-92-8
Molecular Formula:
C30H50O5
Molecular Weight:
490.7150
MDL Number:
MFCD25977156
SMILES:
OCCCO[C@@H]1[C@H](O)C/C(=C/C=C/2\CCC[C@]3([C@H]2CC[C@@H]3[C@@H](CCCC(O)(C)C)C)C)/C(=C)[C@H]1O
Properties
Computed Properties
 
Complexity:
784  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Defined Bond Stereocenter Count:
2  
Formal Charge:
0  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
10  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.3  

Literature

Title: Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase.

Journal: Pharmacology research & perspectives 20150301

Title: Eldecalcitol, a vitamin D analog, reduces bone turnover and increases trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys.

Journal: Bone 20131101

Title: Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels.

Journal: Current medical research and opinion 20120901

Title: Bone effects of vitamin D - Discrepancies between in vivo and in vitro studies.

Journal: Archives of biochemistry and biophysics 20120701

Title: [New approved drugs for osteoporosis in Japan].

Journal: Clinical calcium 20120601

Title: Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength.

Journal: Bone 20120501

Title: Eldecalcitol for the treatment of osteoporosis.

Journal: Drugs of today (Barcelona, Spain : 1998) 20120301

Title: Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20120201

Title: Process development for the practical production of eldecalcitol by linear, convergent and biomimetic syntheses.

Journal: Anticancer research 20120101

Title: The vitamin D analog 1α,25-Dihydroxy-2β-(3-Hydroxypropyloxy) vitamin D(3) (Eldecalcitol) is a potent regulator of calcium and phosphate metabolism.

Journal: Calcified tissue international 20111101

Title: [Frontiers in vitamin D; basic research and clinical application. Exploratory research, biological characteristic and pharmacokinetics of eldecalcitol, a new active vitamin D derivative].

Journal: Clinical calcium 20111101

Title: [Frontiers in vitamin D; basic research and clinical application. Eldecalcitol: the effect on bones and calcium metabolism].

Journal: Clinical calcium 20111101

Title: [Frontiers in vitamin D; Basic research and clinical application. The effects of eldecalcitol on bone mineral density and fracture prevention--Post hoc analysis].

Journal: Clinical calcium 20111101

Title: [Frontiers in vitamin D; Basic research and clinical application. Effect of eldecalcitol on bone structure].

Journal: Clinical calcium 20111101

Title: A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study.

Journal: Bone 20111001

Title: Eldecalcitol: a review of its use in the treatment of osteoporosis.

Journal: Drugs 20110910

Title: Effect of eldecalcitol, an active vitamin D analog, on hip structure and biomechanical properties: 3D assessment by clinical CT.

Journal: Bone 20110901

Title: [Diagnostic imaging of treatment in osteoporosis; new active vitamin D].

Journal: Clinical calcium 20110701

Title: Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism.

Journal: Journal of cellular biochemistry 20110501

Title: [Eldecalcitol (ED-71)].

Journal: Clinical calcium 20110101

Title: [ASBMR 2010 report. Meeting report on the ASBMR. Obstacles in medicine for osteoporosis].

Journal: Clinical calcium 20110101

Title: Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.

Journal: Structure (London, England : 1993) 20101013

Title: Comparison of the effects of eldecalcitol and alfacalcidol on bone and calcium metabolism.

Journal: The Journal of steroid biochemistry and molecular biology 20100701

Title: Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71].

Journal: The Journal of steroid biochemistry and molecular biology 20100701

Title: Eldecalcitol is less effective in suppressing parathyroid hormone compared to calcitriol in vivo.

Journal: The Journal of steroid biochemistry and molecular biology 20100701

Title: D-hormone derivatives for the treatment of osteoporosis: from alfacalcidol to eldecalcitol.

Journal: Mini reviews in medicinal chemistry 20091001

Title: Synthesis of all possible A-ring diastereomers at the 1- and 3-positions of 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) using C2-symmetrical epoxide as a common starting material.

Journal: Anticancer research 20090901

Title: [New bone density conservation agents for osteoporosis under research and development: ED-71].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20071128

Title: Synthesis and biological evaluation of a 3-positon epimer of 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71).

Journal: The Journal of steroid biochemistry and molecular biology 20070301

Title: ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects.

Journal: The Journal of steroid biochemistry and molecular biology 20070301

Title: ED-71, a novel vitamin D analog, promotes bone formation and angiogenesis and inhibits bone resorption after bone marrow ablation.

Journal: Bone 20070201

Title: 1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3 (ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora.

Journal: Bone 20070101

Title: [Therapeutic agents for disorders of bone and calcium metabolism: ED-71].

Journal: Clinical calcium 20070101

Title: Synthesis of putative metabolites of 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D(3) (ED-71).

Journal: Steroids 20060701

Title: [Progress in research on vitamin D analogs].

Journal: Clinical calcium 20060701

Title: [Vitamin-D analogues for osteoporosis].

Journal: Clinical calcium 20060701

Title: [New horizons of ED-71 (vitamin D analog)].

Journal: Clinical calcium 20060101

Title: The determination of 2beta-(3-hydroxypropoxy)-1alpha,25-dihydroxy vitamin D3 (ED-71) in human serum by high-performance liquid chromatography-electrospray tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050905

Title: A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial.

Journal: The Journal of clinical endocrinology and metabolism 20050901

Title: [Vitamin D and its derivatives as anti-osteoporotic drugs].

Journal: Clinical calcium 20050401

Title: [Influencing factors on distraction osteogenesis].

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20040701

Title: [The trend in the development of the active vitamin D3 and its analogues].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040501

Title: ED-71 Chugai.

Journal: Current opinion in investigational drugs (London, England : 2000) 20040401

Title: [ED-71].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040201

Title: A new active vitamin D analog, ED-71, causes increase in bone mass with preferential effects on bone in osteoporotic patients.

Journal: Journal of cellular biochemistry 20030201

Title: Rationale for active vitamin D and analogs in the treatment of osteoporosis.

Journal: Journal of cellular biochemistry 20030201

Title: [Osteoporosis].

Journal: Ryumachi. [Rheumatism] 20021201

Title: ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis.

Journal: Bone 20020401

Title: [Drugs in development for the treatment of osteoporosis: Active vitamin D analog(ED-71)].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020301

Title: History of the development of new vitamin D analogs: studies on 22-oxacalcitriol (OCT) and 2beta-(3-hydroxypropoxy)calcitriol (ED-71).

Journal: Steroids 20010101

Title: Synthesis and biological characterization of 1alpha,24,25-trihydroxy-2beta-(3-hydroxypropoxy)vitamin D(3) (24-hydroxylated ED-71).

Journal: Steroids 20010101

Title: Synthetic studies of vitamin D analogues. XIV. Synthesis and calcium regulating activity of vitamin D3 analogues bearing a hydroxyalkoxy group at the 2 beta-position.

Journal: Chemical & pharmaceutical bulletin 19930601

Title: Effects of two new vitamin D3 derivatives, 22-oxa-1 alpha-25-dihydroxyvitamin D3 (OCT) and 2 beta-(3-hydroxypropoxy)-1 alpha, 25-dihydroxyvitamin D3 (ED-71), on bone metabolism in organ culture.

Journal: Bone 19930101

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Tags:104121-92-8 Molecular Formula|104121-92-8 MDL|104121-92-8 SMILES|104121-92-8 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
Catalog No.: AA008TCY
104121-92-8,MFCD25977156
104121-92-8 | 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
Pack Size: 1mg
Purity: ≥98%
in stock
$179.00 $125.00
Pack Size: 5mg
Purity: ≥98%
in stock
$805.00 $563.00
Pack Size: 10mg
Purity: ≥98%
in stock
$1,340.00 $938.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008TCY
Chemical Name: 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
CAS Number: 104121-92-8
Molecular Formula: C30H50O5
Molecular Weight: 490.7150
MDL Number: MFCD25977156
SMILES: OCCCO[C@@H]1[C@H](O)C/C(=C/C=C/2\CCC[C@]3([C@H]2CC[C@@H]3[C@@H](CCCC(O)(C)C)C)C)/C(=C)[C@H]1O
Properties
Complexity: 784  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 7  
Defined Bond Stereocenter Count: 2  
Formal Charge: 0  
Heavy Atom Count: 35  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 10  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.3  
Literature fold

Title: Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase.

Journal: Pharmacology research & perspectives20150301

Title: Eldecalcitol, a vitamin D analog, reduces bone turnover and increases trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys.

Journal: Bone20131101

Title: Eldecalcitol normalizes bone turnover markers regardless of their pre-treatment levels.

Journal: Current medical research and opinion20120901

Title: Bone effects of vitamin D - Discrepancies between in vivo and in vitro studies.

Journal: Archives of biochemistry and biophysics20120701

Title: [New approved drugs for osteoporosis in Japan].

Journal: Clinical calcium20120601

Title: Combination therapy with eldecalcitol and alendronate has therapeutic advantages over monotherapy by improving bone strength.

Journal: Bone20120501

Title: Eldecalcitol for the treatment of osteoporosis.

Journal: Drugs of today (Barcelona, Spain : 1998)20120301

Title: Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research20120201

Title: Process development for the practical production of eldecalcitol by linear, convergent and biomimetic syntheses.

Journal: Anticancer research20120101

Title: The vitamin D analog 1α,25-Dihydroxy-2β-(3-Hydroxypropyloxy) vitamin D(3) (Eldecalcitol) is a potent regulator of calcium and phosphate metabolism.

Journal: Calcified tissue international20111101

Title: [Frontiers in vitamin D; basic research and clinical application. Exploratory research, biological characteristic and pharmacokinetics of eldecalcitol, a new active vitamin D derivative].

Journal: Clinical calcium20111101

Title: [Frontiers in vitamin D; basic research and clinical application. Eldecalcitol: the effect on bones and calcium metabolism].

Journal: Clinical calcium20111101

Title: [Frontiers in vitamin D; Basic research and clinical application. The effects of eldecalcitol on bone mineral density and fracture prevention--Post hoc analysis].

Journal: Clinical calcium20111101

Title: [Frontiers in vitamin D; Basic research and clinical application. Effect of eldecalcitol on bone structure].

Journal: Clinical calcium20111101

Title: A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures--a randomized, active comparator, double-blind study.

Journal: Bone20111001

Title: Eldecalcitol: a review of its use in the treatment of osteoporosis.

Journal: Drugs20110910

Title: Effect of eldecalcitol, an active vitamin D analog, on hip structure and biomechanical properties: 3D assessment by clinical CT.

Journal: Bone20110901

Title: [Diagnostic imaging of treatment in osteoporosis; new active vitamin D].

Journal: Clinical calcium20110701

Title: Suppression of PTH by the vitamin D analog eldecalcitol is modulated by its high affinity for the serum vitamin D-binding protein and resistance to metabolism.

Journal: Journal of cellular biochemistry20110501

Title: [Eldecalcitol (ED-71)].

Journal: Clinical calcium20110101

Title: [ASBMR 2010 report. Meeting report on the ASBMR. Obstacles in medicine for osteoporosis].

Journal: Clinical calcium20110101

Title: Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer.

Journal: Structure (London, England : 1993)20101013

Title: Comparison of the effects of eldecalcitol and alfacalcidol on bone and calcium metabolism.

Journal: The Journal of steroid biochemistry and molecular biology20100701

Title: Synthesis and preliminary biological evaluation of 20-epi-eldecalcitol [20-epi-1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3: 20-epi-ED-71].

Journal: The Journal of steroid biochemistry and molecular biology20100701

Title: Eldecalcitol is less effective in suppressing parathyroid hormone compared to calcitriol in vivo.

Journal: The Journal of steroid biochemistry and molecular biology20100701

Title: D-hormone derivatives for the treatment of osteoporosis: from alfacalcidol to eldecalcitol.

Journal: Mini reviews in medicinal chemistry20091001

Title: Synthesis of all possible A-ring diastereomers at the 1- and 3-positions of 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) using C2-symmetrical epoxide as a common starting material.

Journal: Anticancer research20090901

Title: [New bone density conservation agents for osteoporosis under research and development: ED-71].

Journal: Nihon rinsho. Japanese journal of clinical medicine20071128

Title: Synthesis and biological evaluation of a 3-positon epimer of 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71).

Journal: The Journal of steroid biochemistry and molecular biology20070301

Title: ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects.

Journal: The Journal of steroid biochemistry and molecular biology20070301

Title: ED-71, a novel vitamin D analog, promotes bone formation and angiogenesis and inhibits bone resorption after bone marrow ablation.

Journal: Bone20070201

Title: 1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3 (ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora.

Journal: Bone20070101

Title: [Therapeutic agents for disorders of bone and calcium metabolism: ED-71].

Journal: Clinical calcium20070101

Title: Synthesis of putative metabolites of 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D(3) (ED-71).

Journal: Steroids20060701

Title: [Progress in research on vitamin D analogs].

Journal: Clinical calcium20060701

Title: [Vitamin-D analogues for osteoporosis].

Journal: Clinical calcium20060701

Title: [New horizons of ED-71 (vitamin D analog)].

Journal: Clinical calcium20060101

Title: The determination of 2beta-(3-hydroxypropoxy)-1alpha,25-dihydroxy vitamin D3 (ED-71) in human serum by high-performance liquid chromatography-electrospray tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20050905

Title: A new active vitamin D, ED-71, increases bone mass in osteoporotic patients under vitamin D supplementation: a randomized, double-blind, placebo-controlled clinical trial.

Journal: The Journal of clinical endocrinology and metabolism20050901

Title: [Vitamin D and its derivatives as anti-osteoporotic drugs].

Journal: Clinical calcium20050401

Title: [Influencing factors on distraction osteogenesis].

Journal: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology20040701

Title: [The trend in the development of the active vitamin D3 and its analogues].

Journal: Nihon rinsho. Japanese journal of clinical medicine20040501

Title: ED-71 Chugai.

Journal: Current opinion in investigational drugs (London, England : 2000)20040401

Title: [ED-71].

Journal: Nihon rinsho. Japanese journal of clinical medicine20040201

Title: A new active vitamin D analog, ED-71, causes increase in bone mass with preferential effects on bone in osteoporotic patients.

Journal: Journal of cellular biochemistry20030201

Title: Rationale for active vitamin D and analogs in the treatment of osteoporosis.

Journal: Journal of cellular biochemistry20030201

Title: [Osteoporosis].

Journal: Ryumachi. [Rheumatism]20021201

Title: ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis.

Journal: Bone20020401

Title: [Drugs in development for the treatment of osteoporosis: Active vitamin D analog(ED-71)].

Journal: Nihon rinsho. Japanese journal of clinical medicine20020301

Title: History of the development of new vitamin D analogs: studies on 22-oxacalcitriol (OCT) and 2beta-(3-hydroxypropoxy)calcitriol (ED-71).

Journal: Steroids20010101

Title: Synthesis and biological characterization of 1alpha,24,25-trihydroxy-2beta-(3-hydroxypropoxy)vitamin D(3) (24-hydroxylated ED-71).

Journal: Steroids20010101

Title: Synthetic studies of vitamin D analogues. XIV. Synthesis and calcium regulating activity of vitamin D3 analogues bearing a hydroxyalkoxy group at the 2 beta-position.

Journal: Chemical & pharmaceutical bulletin19930601

Title: Effects of two new vitamin D3 derivatives, 22-oxa-1 alpha-25-dihydroxyvitamin D3 (OCT) and 2 beta-(3-hydroxypropoxy)-1 alpha, 25-dihydroxyvitamin D3 (ED-71), on bone metabolism in organ culture.

Journal: Bone19930101

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