Home Other Building Blocks 1218777-13-9
1218777-13-9,MFCD00640727
Catalog No.:AA009CJE

1218777-13-9 | CAY10505

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
97%
in stock  
$111.00   $78.00
- +
10mg
97%
in stock  
$145.00   $102.00
- +
25mg
97%
in stock  
$216.00   $152.00
- +
50mg
97%
in stock  
$322.00   $225.00
- +
100mg
97%
in stock  
$463.00   $324.00
- +
250mg
97%
in stock  
$970.00   $679.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009CJE
Chemical Name:
CAY10505
CAS Number:
1218777-13-9
Molecular Formula:
C14H8FNO3S
Molecular Weight:
289.2816
MDL Number:
MFCD00640727
SMILES:
O=C1SC(=Cc2ccc(o2)c2ccc(cc2)F)C(=O)N1
Properties
Computed Properties
 
Complexity:
446  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
3.1  

Literature

Title: Discovery and SAR of thiazolidine-2,4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening.

Journal: Journal of medicinal chemistry 20100325

Title: Sun YY, Lin SH et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. 2013 Jul 19;8(7):e69019.

Title: Tyagi S. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul, 90(7), 881-5.

Title: Hofmann C, et al. PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform. Br J Haematol. 2014 Aug;166(4):529-39.

Title: Jingyi Wang, et al. MiR-1976 Knockdown Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties Inducing Triple-Negative Breast Cancer Metastasis. Cell Death Dis. 2020 Jul 3;11(7):500.

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SDS
Tags:1218777-13-9 Molecular Formula|1218777-13-9 MDL|1218777-13-9 SMILES|1218777-13-9 CAY10505