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Home Other Building Blocks 1221713-92-3
1221713-92-3,MFCD29905447
Catalog No.:AA009VOB

1221713-92-3 | Nps-1034

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$25.00   $18.00
- +
5mg
98+%
in stock  
$50.00   $35.00
- +
50mg
98+%
in stock  
$110.00   $77.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009VOB
Chemical Name:
Nps-1034
CAS Number:
1221713-92-3
Molecular Formula:
C31H23F2N5O3
Molecular Weight:
551.5428
MDL Number:
MFCD29905447
SMILES:
Fc1ccc(cc1)n1c(=O)c(c(n1C)C)C(=O)Nc1ccc(c(c1)F)Oc1ccnc2c1c(c[nH]2)c1ccccc1
Properties
Computed Properties
 
Complexity:
998  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
5.8  

Downstream Synthesis Route
75-75-2    1221713-92-3   
C31H23F2N5O3*CH4O3S 

[1]CrystalGrowthandDesign,2013,vol.13,p.3958-3968

110-04-3    1221713-92-3   
C31H23F2N5O3*0.5C2H6O6S2*C2H3N 

[1]CrystalGrowthandDesign,2013,vol.13,p.3958-3968

1221713-92-3    104-15-4   
C31H23F2N5O3*C7H8O3S 

[1]CrystalGrowthandDesign,2013,vol.13,p.3958-3968

Literature

Title: Micro-electrode measurement of the internal pH of crab muscle fibres.

Journal: The Journal of physiology 19751101

Title: Rho JK, et al. MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation. Cancer Res. 2014 Jan 1;74(1):253-62.

Title: Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2014 Jun;32(3):389-99.

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SDS
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Tags:1221713-92-3 Molecular Formula|1221713-92-3 MDL|1221713-92-3 SMILES|1221713-92-3 Nps-1034