Name: Name:Nps-1034
Brand: AABLOCKS
SKU: AA009VOB
Rating: 90 (10 reviews)

Catalog No.: AA009VOB

1221713-92-3 | Nps-1034

Pack Size： 1mg

Purity： 98+%

in stock

$25.00 $18.00

Pack Size： 5mg

Purity： 98+%

in stock

$50.00 $35.00

Pack Size： 50mg

Purity： 98+%

in stock

$111.00 $78.00

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Technical Information

Catalog Number: AA009VOB

Chemical Name: Nps-1034

CAS Number: 1221713-92-3

Molecular Formula: C31H23F2N5O3

Molecular Weight: 551.5428

MDL Number: MFCD29905447

SMILES: Fc1ccc(cc1)n1c(=O)c(c(n1C)C)C(=O)Nc1ccc(c(c1)F)Oc1ccnc2c1c(c[nH]2)c1ccccc1

Properties

Complexity: 998

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 41

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 5.8

Downstream Synthesis Route

75-75-2

1221713-92-3

C31H23F2N5O3*CH4O3S

[1]CrystalGrowthandDesign,2013,vol.13,p.3958-3968

110-04-3

1221713-92-3

C31H23F2N5O3*0.5C2H6O6S2*C2H3N

[1]CrystalGrowthandDesign,2013,vol.13,p.3958-3968

1221713-92-3

104-15-4

C31H23F2N5O3*C7H8O3S

[1]CrystalGrowthandDesign,2013,vol.13,p.3958-3968

Literature fold

Title: Micro-electrode measurement of the internal pH of crab muscle fibres.

Journal: The Journal of physiology19751101

Title: Rho JK, et al. MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation. Cancer Res. 2014 Jan 1;74(1):253-62.

Title: Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2014 Jun;32(3):389-99.

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