Home Other Building Blocks 130089-98-4
130089-98-4,MFCD00559986
Catalog No.:AA00A0G4

130089-98-4 | NQ301

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%
in stock  
$28.00   $20.00
- +
10mg
98%
in stock  
$47.00   $33.00
- +
25mg
98%
in stock  
$94.00   $66.00
- +
50mg
98%
in stock  
$159.00   $111.00
- +
100mg
98%
in stock  
$269.00   $188.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00A0G4
Chemical Name:
NQ301
CAS Number:
130089-98-4
Molecular Formula:
C18H12ClNO3
Molecular Weight:
325.7458
MDL Number:
MFCD00559986
SMILES:
ClC1=C(Nc2ccc(cc2)C(=O)C)C(=O)c2c(C1=O)cccc2
Properties
Computed Properties
 
Complexity:
561  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
2.9  

Downstream Synthesis Route

[1]Satheshkumar,Angupillai;Elango,KuppanagounderP.[SpectrochimicaActaPartA:MolecularandBiomolecularSpectroscopy,2012,vol.98,p.378-383,6]

[2]Prachayasittikul,Veda;Pingaew,Ratchanok;Worachartcheewan,Apilak;Nantasenamat,Chanin;Prachayasittikul,Supaluk;Ruchirawat,Somsak;Prachayasittikul,Virapong[EuropeanJournalofMedicinalChemistry,2014,vol.84,p.247-263]

Literature

Title: An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets.

Journal: Basic & clinical pharmacology & toxicology 20050901

Title: Antiplatelet effect of 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone (NQ301): a possible mechanism through inhibition of intracellular Ca2+ mobilization.

Journal: Biological & pharmaceutical bulletin 20010601

Title: Jin YR, et al. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets. Basic Clin Pharmacol Toxicol. 2005 Sep;97(3):162-7.

Title: Zhang YH, et al. Antiplatelet effect of 2-chloro-3-(4-acetophenyl)-amino-1,4-naphthoquinone (NQ301): a possible mechanism through inhibition of intracellular Ca2+ mobilization. Biol Pharm Bull. 2001 Jun;24(6):618-22.

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SDS
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