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Title: Design, synthesis, and structure-activity relationships of novel pyrazolo[5,1-b]thiazole derivatives as potent and orally active corticotropin-releasing factor 1 receptor antagonists.
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Title: Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses.
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Title: Depressive and cardiovascular disease comorbidity in a rat model of social stress: a putative role for corticotropin-releasing factor.
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Title: Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor.
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Title: Discovery of potent, metabolically stable purine CRF-1 antagonists with differentiated binding kinetic profiles.
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Title: Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
Journal: Journal of medicinal chemistry 20110623
Title: Persistent anxiolytic affects after chronic administration of the CRF₁ receptor antagonist R121919 in rats.
Journal: Neuropharmacology 20110601
Title: Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus.
Journal: The Journal of pharmacology and experimental therapeutics 20110401
Title: [¹²⁵I]YP20: a novel radioligand specific for the extracellular domain of the CRF₁ receptor.
Journal: European journal of pharmacology 20101215
Title: Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties.
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Title: Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence.
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Title: Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775.
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Title: 2-Arylpyrimidines: novel CRF-1 receptor antagonists.
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Title: Restraint stress and ethanol consumption in two mouse strains.
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Title: CRH-sub-1 receptor antagonists for the treatment of depression and anxiety.
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Title: The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal.
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Title: The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal.
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Title: Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats.
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Title: Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats.
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Title: Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats.
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Title: Impact of state of arousal and stress neuropeptides on urodynamic function in freely moving rats.
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Title: Glucocorticoid receptor and treatment of psychotic major depression.
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Title: Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor.
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Title: Analysis of the hormone-binding domain of steroid receptors using chimeras generated by homologous recombination.
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Title: Design and synthesis of tricyclic imidazo[4,5-b]pyridin-2-ones as corticotropin-releasing factor-1 antagonists.
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Title: The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats.
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Title: Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core.
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Title: Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system.
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Title: Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists.
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Title: Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775.
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Title: Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists.
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Title: Role of corticotropin-releasing factor receptors type 1 and 2 in modulating the rat adrenocorticotropin response to stressors.
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Title: The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats.
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Title: Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist.
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Title: The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety.
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Title: Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated.
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