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1594092-37-1,MFCD28015098
Catalog No.:AA00ABFX

1594092-37-1 | Az 191

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$156.00   $109.00
- +
10mg
98%
in stock  
$266.00   $187.00
- +
25mg
98%
in stock  
$529.00   $370.00
- +
50mg
98%
in stock  
$640.00   $448.00
- +
100mg
98%
in stock  
$1,084.00   $759.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABFX
Chemical Name:
Az 191
CAS Number:
1594092-37-1
Molecular Formula:
C24H27N7O
Molecular Weight:
429.5175
MDL Number:
MFCD28015098
SMILES:
COc1cc(ccc1Nc1nccc(n1)c1cn(c2c1ccnc2)C)N1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
601  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.7  

Downstream Synthesis Route

[1]Kettle,JasonG.;Ballard,Peter;Bardelle,Catherine;Cockerill,Mark;Colclough,Nicola;Critchlow,SusanE.;Debreczeni,Judit;Fairley,Gary;Fillery,Shaun;Graham,MarkA.;Goodwin,Louise;Guichard,Sylvie;Hudson,Kevin;Ward,RichardA.;Whittaker,David[JournalofMedicinalChemistry,2015,vol.58,#6,p.2834-2844]

67058-76-8   
N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(1-methyl-1H-pyrrolo2,3-cpyridin-3-yl)pyrimidin-2-amine 

[1]JournalofMedicinalChemistry,2015,vol.58,p.2834-2844

[1]Kettle,JasonG.;Ballard,Peter;Bardelle,Catherine;Cockerill,Mark;Colclough,Nicola;Critchlow,SusanE.;Debreczeni,Judit;Fairley,Gary;Fillery,Shaun;Graham,MarkA.;Goodwin,Louise;Guichard,Sylvie;Hudson,Kevin;Ward,RichardA.;Whittaker,David[JournalofMedicinalChemistry,2015,vol.58,#6,p.2834-2844]

[1]Kettle,JasonG.;Ballard,Peter;Bardelle,Catherine;Cockerill,Mark;Colclough,Nicola;Critchlow,SusanE.;Debreczeni,Judit;Fairley,Gary;Fillery,Shaun;Graham,MarkA.;Goodwin,Louise;Guichard,Sylvie;Hudson,Kevin;Ward,RichardA.;Whittaker,David[JournalofMedicinalChemistry,2015,vol.58,#6,p.2834-2844]

[1]Kettle,JasonG.;Ballard,Peter;Bardelle,Catherine;Cockerill,Mark;Colclough,Nicola;Critchlow,SusanE.;Debreczeni,Judit;Fairley,Gary;Fillery,Shaun;Graham,MarkA.;Goodwin,Louise;Guichard,Sylvie;Hudson,Kevin;Ward,RichardA.;Whittaker,David[JournalofMedicinalChemistry,2015,vol.58,#6,p.2834-2844]

Literature

Title: Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis.

Journal: Journal of medicinal chemistry 20150326

Title: A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288).

Journal: The Biochemical journal 20140101

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SDS
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