Home Other Building Blocks 172747-50-1
172747-50-1,MFCD06804624
Catalog No.:AA00AB6X

172747-50-1 | SB 202474

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1mg
≥97%
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$202.00   $141.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AB6X
Chemical Name:
SB 202474
CAS Number:
172747-50-1
Molecular Formula:
C17H17N3O
Molecular Weight:
279.3364
MDL Number:
MFCD06804624
SMILES:
CCc1[nH]c(nc1c1ccncc1)c1ccc(cc1)OC
Properties
Computed Properties
 
Complexity:
311  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.1  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway.

Journal: PloS one 20120101

Title: Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase.

Journal: Journal of vascular research 20120101

Title: Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death.

Journal: Journal of biomedical science 20120101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication.

Journal: Experimental parasitology 20110601

Title: Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells.

Journal: World journal of gastroenterology 20100428

Title: p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis.

Journal: Journal of cellular physiology 20100101

Title: CXCR4 mediates the homing of B cell progenitor acute lymphoblastic leukaemia cells to the bone marrow via activation of p38MAPK.

Journal: British journal of haematology 20090501

Title: The involvement of a P38-like MAP kinase in ABA-induced and H2O2-mediated stomatal closure in Vicia faba L.

Journal: Plant cell reports 20080201

Title: Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer.

Journal: Pathology international 20071001

Title: Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060601

Title: Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes.

Journal: Toxicology letters 20060208

Title: Voltage-gated sodium channel Nav1.6 is modulated by p38 mitogen-activated protein kinase.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713

Title: Pyridinylimidazole p38 mitogen-activated protein kinase inhibitors block intracellular Toxoplasma gondii replication.

Journal: International journal for parasitology 20020701

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