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Home Other Building Blocks 184044-10-8
184044-10-8,MFCD09055362
Catalog No.:AA00ACWL

184044-10-8 | 2-(Piperidin-4-yl)acetamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
2 weeks  
$908.00   $635.00
- +
5g
95%
2 weeks  
$2,693.00   $1,885.00
- +
10g
95%
2 weeks  
$4,479.00   $3,135.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ACWL
Chemical Name:
2-(Piperidin-4-yl)acetamide
CAS Number:
184044-10-8
Molecular Formula:
C7H14N2O
Molecular Weight:
142.1989
MDL Number:
MFCD09055362
SMILES:
NC(=O)CC1CCNCC1
Properties
Computed Properties
 
Complexity:
119  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
-0.6  

Downstream Synthesis Route
184044-10-8   
rac-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carboxylicacid 
 
rac-2-{1-(2R,3S,4R,5S)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl-piperidin-4-yl}-acetamide 

[1]CurrentPatentAssignee:ROCHEHOLDINGAG-US2010/75948,2010,A1Locationinpatent:Page/Pagecolumn153

32315-10-9    184044-10-8   
(2R,6S,13aS,14aR,16aS)-6-amino-N-(cyclopropylsulfonyl)-2-8-methyl-2-4-(1-methylethyl)-1,3-thiazol-2-yl-7-(methyloxy)-4-quinolinyloxy}-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropaepyrrolo1,2-a1,4diazacyclopentadecine-14a(5H)carboxamide 
 
(2R,6S,13aS,14aR,16aS)-6-(4-(2-amino-2-oxoethyl)-1-piperidinylcarbonyl}amino)-N-(cyclopropylsulfonyl)2-8-methyl-2-4-(1-methylethyl)-1,3-thiazol-2-yl-7-(methyloxy)-4-quinolinyloxy}-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropaepyrrolo1,2-a1,4diazacyclopentadecine-14a(5H)-carboxamide 

[1]CurrentPatentAssignee:PFIZERINC-US2010/196321,2010,A1Locationinpatent:Page/Pagecolumn35

32315-10-9    184044-10-8   
C38H48N6O7S2*2ClH 
 
(2R,6S,13aS,14aR,16aS)-6-(4-(2-amino-2-oxoethyl)-1-piperidinylcarbonyl}amino)-N-(cyclopropylsulfonyl)2-8-methyl-2-4-(1-methylethyl)-1,3-thiazol-2-yl-7-(methyloxy)-4-quinolinyloxy}-5,16-dioxo-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropaepyrrolo1,2-a1,4diazacyclopentadecine-14a(5H)-carboxamide 

[1]Kazmierski,WieslawM.;Hamatake,Robert;Duan,Maosheng;Wright,LoisL.;Smith,GaryK.;Jarvest,RichardL.;Ji,Jing-Jing;Cooper,JoelP.;Tallant,MatthewD.;Crosby,RenaeM.;Creech,Katrina;Wang,Amy;Li,Xianfeng;Zhang,Suoming;Zhang,Yong-Kang;Liu,Yang;Ding,CharlesZ.;Zhou,Yasheen;Plattner,JacobJ.;Baker,StephenJ.;Bu,Wei;Liu,Liang[JournalofMedicinalChemistry,2012,vol.55,#7,p.3021-3026]

[1]Bogolubsky,AndreyV.;Moroz,YuriiS.;Mykhailiuk,PavelK.;Granat,DmitryS.;Pipko,SergeyE.;Konovets,AnzhelikaI.;Doroschuk,Roman;Tolmachev,Andrey[ACSCombinatorialScience,2014,vol.16,#6,p.303-308]

[1]CurrentPatentAssignee:CHINAPETROCHEMICALCORPORATION-CN104557610,2018,BLocationinpatent:Paragraph0138;0139;0140;0151;0152

Literature

Title: Structural analysis of 2-piperidin-4-yl-actamide derivatives for hERG blocking and MCH R1 antagonistic activities.

Journal: Current drug discovery technologies 20120301

Title: Optimization of 2-piperidin-4-yl-acetamides as melanin-concentrating hormone receptor 1 (MCH-R1) antagonists: Designing out hERG inhibition.

Journal: Bioorganic & medicinal chemistry letters 20090801

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