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187034-31-7,MFCD22581509
Catalog No.:AA00AB79

187034-31-7 | TAPI-2

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1mg
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$362.00   $253.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AB79
Chemical Name:
TAPI-2
CAS Number:
187034-31-7
Molecular Formula:
C19H37N5O5
Molecular Weight:
415.5276
MDL Number:
MFCD22581509
SMILES:
NCCNC(=O)C(NC(=O)C(C(C)(C)C)NC(=O)C(CC(=O)NO)CC(C)C)C
Properties
Computed Properties
 
Complexity:
574  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
12  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-0.1  

Literature

Title: Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin.

Journal: Archives of toxicology 20121201

Title: Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells.

Journal: Archives of toxicology 20121001

Title: Thromboxane prostanoid receptor stimulation induces shedding of the transmembrane chemokine CX3CL1 yet enhances CX3CL1-dependent leukocyte adhesion.

Journal: American journal of physiology. Cell physiology 20100601

Title: Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface.

Journal: Cellular signalling 20100301

Title: Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection.

Journal: Experimental cell research 20091210

Title: Statin's excitoprotection is mediated by sAPP and the subsequent attenuation of calpain-induced truncation events, likely via rho-ROCK signaling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090909

Title: Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases.

Journal: Cellular signalling 20090801

Title: Novel approach for formation of platelet-like particles from mouse embryonic stem cells without using feeder cells.

Journal: The Kurume medical journal 20090101

Title: Regulation of the receptor for TNFalpha, TNFR1, in human conjunctival epithelial cells.

Journal: Investigative ophthalmology & visual science 20080901

Title: Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening.

Journal: Analytical biochemistry 20070715

Title: Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.

Journal: Cancer science 20070501

Title: Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.

Journal: Journal of neuroscience research 20060901

Title: Proteasome inhibition induces TNFR1 shedding from human airway epithelial (NCI-H292) cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20050801

Title: Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.

Journal: The Journal of biological chemistry 20050415

Title: The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE).

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040101

Title: Regulated cell surface pro-EGF ectodomain shedding is a zinc metalloprotease-dependent process.

Journal: The Journal of biological chemistry 20031114

Title: Tomoregulin ectodomain shedding by proinflammatory cytokines.

Journal: Life sciences 20030815

Title: Shedding of the transferrin receptor is mediated constitutively by an integral membrane metalloprotease sensitive to tumor necrosis factor alpha protease inhibitor-2.

Journal: The Journal of biological chemistry 20021011

Title: Kruse MN, et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J. 2004 Mar 1;378(Pt 2):383-9.

Title: Shiori Haga, et al. TACE Antagonists Blocking ACE2 Shedding Caused by the Spike Protein of SARS-CoV Are Candidate Antiviral Compounds. Antiviral Res. 2010 Mar;85(3):551-5.

Title: Wang R, et al. A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. Stem Cells Transl Med. 2016 Mar;5(3):331-8.

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