Home Other Building Blocks 187227-45-8
187227-45-8,MFCD00953940
Catalog No.:AA00ABIC

187227-45-8 | Oseltamivir acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$118.00   $82.00
- +
5mg
≥98%
in stock  
$172.00   $120.00
- +
10mg
≥98%
in stock  
$245.00   $172.00
- +
25mg
95%
in stock  
$347.00   $243.00
- +
100mg
95%
in stock  
$801.00   $561.00
- +
250mg
95%
in stock  
$1,287.00   $901.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABIC
Chemical Name:
Oseltamivir acid
CAS Number:
187227-45-8
Molecular Formula:
C14H24N2O4
Molecular Weight:
284.3514
MDL Number:
MFCD00953940
SMILES:
CCC(O[C@@H]1C=C(C[C@@H]([C@H]1NC(=O)C)N)C(=O)O)CC
Properties
Computed Properties
 
Complexity:
391  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
6  
XLogP3:
-1.9  

Literature

Title: Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120801

Title: Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120701

Title: Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus.

Journal: Bioorganic & medicinal chemistry 20120315

Title: Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir.

Journal: Bioorganic & medicinal chemistry 20110815

Title: Choroid plexus transport: gene deletion studies.

Journal: Fluids and barriers of the CNS 20110101

Title: Oseltamivir (tamiflu) induced depressive episode in a female adolescent.

Journal: Psychiatry investigation 20101201

Title: Oseltamivir (tamiflu) is a substrate of peptide transporter 1.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090801

Title: Aurintricarboxylic acid inhibits influenza virus neuraminidase.

Journal: Antiviral research 20090201

Title: Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic anion transporter 3 (Oat3/Slc22a8) and multidrug resistance-associated protein 4 (Mrp4/Abcc4).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090201

Title: Design, synthesis, inhibitory activity, and SAR studies of hydrophobic p-aminosalicylic acid derivatives as neuraminidase inhibitors.

Journal: Bioorganic & medicinal chemistry 20080401

Title: P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201

Title: A QSAR study on influenza neuraminidase inhibitors.

Journal: Bioorganic & medicinal chemistry 20060215

Title: Investigation of neuraminidase-substrate recognition using molecular dynamics and free energy calculations.

Journal: Journal of medicinal chemistry 20031218

Title: In vitro and in vivo activities of T-705 and oseltamivir against influenza virus.

Journal: Antiviral chemistry & chemotherapy 20030901

Title: Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.

Journal: Biochemistry 20030128

Title: Comparison of colorimetric, fluorometric, and visual methods for determining anti-influenza (H1N1 and H3N2) virus activities and toxicities of compounds.

Journal: Journal of virological methods 20021001

Title: In vitro selection and characterization of influenza A (A/N9) virus variants resistant to a novel neuraminidase inhibitor, A-315675.

Journal: Journal of virology 20020601

Title: Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza.

Journal: Expert opinion on investigational drugs 20020601

Title: Structural studies of the resistance of influenza virus neuramindase to inhibitors.

Journal: Journal of medicinal chemistry 20020523

Title: In vitro and in vivo activities of anti-influenza virus compound T-705.

Journal: Antimicrobial agents and chemotherapy 20020401

Title: In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication.

Journal: Antimicrobial agents and chemotherapy 20020401

Title: The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020101

Title: Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201.

Journal: Antiviral research 20011201

Title: Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants.

Journal: Antimicrobial agents and chemotherapy 20011201

Title: Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir.

Journal: Antimicrobial agents and chemotherapy 20010401

Title: In vitro and in vivo assay systems for study of influenza virus inhibitors.

Journal: Antiviral research 20001001

Title: BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.

Journal: Journal of medicinal chemistry 20000921

Title: Development of a high-performance liquid chromatographic-mass spectrometric assay for the specific and sensitive quantification of Ro 64-0802, an anti-influenza drug, and its pro-drug, oseltamivir, in human and animal plasma and urine.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20000818

Title: Carbocyclic influenza neuraminidase inhibitors possessing a C3-cyclic amine side chain: synthesis and inhibitory activity.

Journal: Bioorganic & medicinal chemistry letters 20000605

Title: Synthesis and evaluation of 1,4,5,6-tetrahydropyridazine derivatives as influenza neuraminidase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 19990705

Title: Characterization of human influenza virus variants selected in vitro in the presence of the neuraminidase inhibitor GS 4071.

Journal: Antimicrobial agents and chemotherapy 19981201

Title: A new series of C3-aza carbocyclic influenza neuraminidase inhibitors: synthesis and inhibitory activity.

Journal: Bioorganic & medicinal chemistry letters 19981201

Title: Structure-activity relationship studies of novel carbocyclic influenza neuraminidase inhibitors.

Journal: Journal of medicinal chemistry 19980702

Title: GS4071 is a slow-binding inhibitor of influenza neuraminidase from both A and B strains.

Journal: Biochemical and biophysical research communications 19980317

Title: Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.

Journal: Antimicrobial agents and chemotherapy 19980301

Title: Li W, et al. Identification of GS 4104 as an orally bioavailable prodrug of the influenza virus neuraminidase inhibitor GS 4071. Antimicrob Agents Chemother. 1998 Mar;42(3):647-53.

Title: Ghosh GC, et al. Oseltamivir carboxylate, the active metabolite of oseltamivir phosphate (Tamiflu), detected in sewage discharge and river water in Japan. Environ Health Perspect. 2010 Jan;118(1):103-7.

Title: Ferraris O, et al. Sensitivity of influenza viruses to zanamivir and oseltamivir: a study performed on viruses circulating in France prior to the introduction of neuraminidase inhibitors in clinical practice. Antiviral Res. 2005 Oct;68(1):43-8.

Title: Gubareva LV, et al. Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants.Antimicrob Agents Chemother. 2001 Dec;45(12):3403-8.

Title: Yen HL, et al. Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice. J Infect Dis. 2005 Aug 15;192(4):665-72.

Title: Hoffmann G, et al. Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system. Antimicrob Agents Chemother. 2009 Nov;53(11):4753-61.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:187227-45-8 Molecular Formula|187227-45-8 MDL|187227-45-8 SMILES|187227-45-8 Oseltamivir acid