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194798-83-9,MFCD28978011
Catalog No.:AA00ABR3

194798-83-9 | Fosfluconazole

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10mg
99%
in stock  
$407.00   $285.00
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25mg
99%
in stock  
$672.00   $470.00
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100mg
99%
in stock  
$1,529.00   $1,070.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABR3
Chemical Name:
Fosfluconazole
CAS Number:
194798-83-9
Molecular Formula:
C13H13F2N6O4P
Molecular Weight:
386.2507
MDL Number:
MFCD28978011
SMILES:
Fc1ccc(c(c1)F)C(OP(=O)(O)O)(Cn1cncn1)Cn1cncn1
Properties
Computed Properties
 
Complexity:
511  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
-0.6  

Literature

Title: Population pharmacokinetics of fluconazole after administration of fosfluconazole and fluconazole in critically ill patients.

Journal: Journal of clinical pharmacy and therapeutics 20120601

Title: Dapsone-induced agranulocytosis leading to perianal abscess and death: a case report.

Journal: Journal of medical case reports 20110101

Title: Disseminated aspergillosis following resolution of Pneumocystis pneumonia with sustained elevation of beta-glucan in an Intensive Care Unit: a case report.

Journal: Infection 20091201

Title: [Comparison of micafungin and fosfluconazole as prophylaxis for invasive fungal infection during neutropenia in children undergoing chemotherapy and hematopoietic stem cell transplantation].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20091201

Title: [Case of basilar artery occlusion caused by mucormycotic embolism in the course of myelodysplastic syndrome].

Journal: Brain and nerve = Shinkei kenkyu no shinpo 20090901

Title: Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090701

Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.

Journal: PloS one 20090101

Title: Fosfluconazole for antifungal prophylaxis in very low birth weight infants.

Journal: International journal of pediatrics 20090101

Title: [Clinical efficacies of antifungal injections].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20081201

Title: [Hypercalcemia associated with all-trans retinoic acid therapy for microgranular type acute promyelocytic leukemia].

Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20080601

Title: [Improved outcome in brain abscess during induction in acute myelocytic leukemia].

Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20070501

Title: Elevation of activated platelet-dependent chemokines and soluble cell adhesion molecules in patients with hematologic malignancies and high levels of beta-D-glucan.

Journal: Pathophysiology of haemostasis and thrombosis 20070101

Title: Infectious myositis involving the piriformis in a patient with rheumatoid arthritis.

Journal: Modern rheumatology 20060101

Title: Pharmacokinetics of fluconazole and fosfluconazole after intraperitoneal administration to peritoneal dialysis rats.

Journal: Drug metabolism and pharmacokinetics 20051201

Title: The effects of hepatic impairment on the pharmacokinetics of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole.

Journal: British journal of clinical pharmacology 20050201

Title: [A case of cryptococcal meningitis presenting initially as bilateral hearing loss].

Journal: No to shinkei = Brain and nerve 20041001

Title: Pharmacokinetics of fosfluconazole and fluconazole following multiple intravenous administration of fosfluconazole in healthy male volunteers.

Journal: British journal of clinical pharmacology 20040701

Title: [Nonclinical studies and clinical studies on fosfluconazole, a triazole antifungal agent (Prodif)].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040701

Title: Comparison of the pharmacokinetics of fosfluconazole and fluconazole after single intravenous administration of fosfluconazole in healthy Japanese and Caucasian volunteers.

Journal: European journal of clinical pharmacology 20040601

Title: The effects of renal impairment on the pharmacokinetics and safety of fosfluconazole and fluconazole following a single intravenous bolus injection of fosfluconazole.

Journal: British journal of clinical pharmacology 20040601

Title: Pharmacokinetics and safety of Fosfluconazole after single intravenous bolus injection in healthy male Japanese volunteers.

Journal: Journal of clinical pharmacology 20040301

Title: Hagiya H, et al. Successful treatment of recurrent candidemia due to candidal thrombophlebitis associated with a central venous catheter using a combination of Fosfluconazole and micafungin. Intern Med. 2013;52(18):2139-43.

Title: Yuan H, et al. Evaluation of in vitro models for screening alkaline phosphatase-mediated bioconversion of phosphate ester prodrugs. Drug Metab Dispos. 2009 Jul;37(7):1443-7.

Title: Aoyama T, et al. Pharmacokinetics of fluconazole and Fosfluconazole after intraperitoneal administration to peritoneal dialysis rats. Drug Metab Pharmacokinet. 2005 Dec;20(6):485-90.

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