Home Other Building Blocks 147254-64-6
147254-64-6,MFCD00920915
Catalog No.:AA00ABIR

147254-64-6 | Ranirestat

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
96%
1 week  
$373.00   $261.00
- +
10mg
96%
1 week  
$565.00   $395.00
- +
25mg
96%
1 week  
$1,130.00   $791.00
- +
50mg
96%
1 week  
$1,777.00   $1,244.00
- +
100mg
96%
1 week  
$2,812.00   $1,969.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABIR
Chemical Name:
Ranirestat
CAS Number:
147254-64-6
Molecular Formula:
C17H11BrFN3O4
Molecular Weight:
420.1893
MDL Number:
MFCD00920915
SMILES:
O=C1NC(=O)[C@]2(C1)C(=O)N(Cc1ccc(cc1F)Br)C(=O)c1n2ccc1
Properties
Computed Properties
 
Complexity:
689  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
1.3  

Literature

Title: A concise enantioselective synthesis of (-)-ranirestat.

Journal: Organic letters 20100319

Title: Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review.

Journal: Journal of diabetes and its complications 20100101

Title: Inventing and understanding catalytic, enantioselective reactions.

Journal: Current opinion in drug discovery & development 20091101

Title: Ranirestat for the management of diabetic sensorimotor polyneuropathy.

Journal: Diabetes care 20090701

Title: Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux.

Journal: Journal of pharmacological sciences 20090201

Title: An improved lanthanum catalyst system for asymmetric amination: toward a practical asymmetric synthesis of AS-3201 (Ranirestat).

Journal: Organic letters 20080703

Title: Long-term treatment with ranirestat (AS-3201), a potent aldose reductase inhibitor, suppresses diabetic neuropathy and cataract formation in rats.

Journal: Journal of pharmacological sciences 20080701

Title: Ranirestat (AS-3201), a potent aldose reductase inhibitor, reduces sorbitol levels and improves motor nerve conduction velocity in streptozotocin-diabetic rats.

Journal: Journal of pharmacological sciences 20080701

Title: Stability and hydrolysis kinetics of spirosuccinimide type inhibitors of aldose reductase in aqueous solution and retardation of their hydrolysis by the target enzyme.

Journal: Journal of pharmaceutical sciences 20080401

Title: Ranirestat as a therapeutic aldose reductase inhibitor for diabetic complications.

Journal: Expert opinion on investigational drugs 20080401

Title: Stereospecific recognition of a spirosuccinimide type aldose reductase inhibitor (AS-3201) by plasma proteins: a significant role of specific binding by serum albumin in the improved potency and stability.

Journal: Biochemical pharmacology 20060112

Title: Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy.

Journal: Diabetes care 20060101

Title: [Role of polyol pathway in pathogenesis of diabetic microangiopathy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050601

Title: [Progress on the drug therapy for diabetic microangiopathies: aldose reductase inhibitor].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20050601

Title: Aldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy.

Journal: Diabetes care 20041001

Title: Uridine diphosphate sugar-selective conjugation of an aldose reductase inhibitor (AS-3201) by UDP-glucuronosyltransferase 2B subfamily in human liver microsomes.

Journal: Biochemical pharmacology 20040401

Title: Stereospecific interaction of a novel spirosuccinimide type aldose reductase inhibitor, AS-3201, with aldose reductase.

Journal: Biochemistry 20010727

Title: Matsumoto T, et al. Improvement of motor nerve conduction velocity in diabetic rats requires normalization of the polyol pathway metabolites flux. J Pharmacol Sci. 2009 Feb;109(2):203-10.

Title: Toyoda F, et al. Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res. 2014;2014:672590.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 147254-64-6
Tags:147254-64-6 Molecular Formula|147254-64-6 MDL|147254-64-6 SMILES|147254-64-6 Ranirestat