+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Other Building Blocks 1642303-38-5
1642303-38-5,MFCD28385868
Catalog No.:AA00ABM0

1642303-38-5 | PDE1-IN-1 (phosphate)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$116.00   $81.00
- +
5mg
≥98%
in stock  
$509.00   $356.00
- +
10mg
≥98%
in stock  
$903.00   $632.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABM0
Chemical Name:
PDE1-IN-1 (phosphate)
CAS Number:
1642303-38-5
Molecular Formula:
C29H29FN7O5P
Molecular Weight:
605.5566
MDL Number:
MFCD28385868
SMILES:
OP(=O)(O)O.Fc1cccc(n1)c1ccc(cc1)Cn1nc2c(c1Nc1ccccc1)c(=O)n(c1=N[C@H]3[C@@H](n21)CCC3)C
Properties
Computed Properties
 
Complexity:
953  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
5  

Downstream Synthesis Route

[1]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2013/192556,2013,A2

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED;INTRA-CELLULARTHERAPIES,INC.-WO2014/205354,2014,A2

[1]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2013/192556,2013,A2

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED;INTRA-CELLULARTHERAPIES,INC.-WO2014/205354,2014,A2

[3]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2021/226407,2021,A1

[1]Li,Peng;Zheng,Hailin;Zhao,Jun;Zhang,Lei;Yao,Wei;Zhu,Hongwen;DavidBeard;Ida,Koh;Lane,Weston;Snell,Gyorgy;Sogabe,Satoshi;Heyser,CharlesJ.;Snyder,GretchenL.;Hendrick,JosephP.;Vanover,KimberlyE.;Davis,RobertE.;Wennogle,LawrenceP.[JournalofMedicinalChemistry,2016,vol.59,#3,p.1149-1164]

[2]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2021/226407,2021,A1Locationinpatent:Paragraph00036

[3]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2013/192556,2013,A2Locationinpatent:Paragraph0035-0040

[4]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED;INTRA-CELLULARTHERAPIES,INC.-WO2014/205354,2014,A2Locationinpatent:Page/Pagecolumn0094

[1]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2013/192556,2013,A2

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED;INTRA-CELLULARTHERAPIES,INC.-WO2014/205354,2014,A2

[3]Li,Peng;Zheng,Hailin;Zhao,Jun;Zhang,Lei;Yao,Wei;Zhu,Hongwen;DavidBeard;Ida,Koh;Lane,Weston;Snell,Gyorgy;Sogabe,Satoshi;Heyser,CharlesJ.;Snyder,GretchenL.;Hendrick,JosephP.;Vanover,KimberlyE.;Davis,RobertE.;Wennogle,LawrenceP.[JournalofMedicinalChemistry,2016,vol.59,#3,p.1149-1164]

[4]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2021/226407,2021,A1

[1]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2013/192556,2013,A2

[2]CurrentPatentAssignee:TAKEDAPHARMACEUTICALCOMPANYLIMITED;INTRA-CELLULARTHERAPIES,INC.-WO2014/205354,2014,A2

[3]Li,Peng;Zheng,Hailin;Zhao,Jun;Zhang,Lei;Yao,Wei;Zhu,Hongwen;DavidBeard;Ida,Koh;Lane,Weston;Snell,Gyorgy;Sogabe,Satoshi;Heyser,CharlesJ.;Snyder,GretchenL.;Hendrick,JosephP.;Vanover,KimberlyE.;Davis,RobertE.;Wennogle,LawrenceP.[JournalofMedicinalChemistry,2016,vol.59,#3,p.1149-1164]

[4]CurrentPatentAssignee:INTRA-CELLULARTHERAPIES,INC.-WO2021/226407,2021,A1

Literature

Title: Li P, et al. Discovery of Potent and Selective Inhibitors of Phosphodiesterase 1 for the Treatment of Cognitive Impairment Associated with Neurodegenerative and Neuropsychiatric Diseases. J Med Chem. 2016;59(3):1149-1164.

Title: Snyder GL, et al. Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats. Psychopharmacology (Berl). 2016;233(17):3113-3124.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1642303-38-5
1160521-50-5

1160521-50-5

 1351961-58-4

1351961-58-4

 1351961-58-4

1351961-58-4

 1351961-58-4

1351961-58-4
Building Blocks
More >
Tags:1642303-38-5 Molecular Formula|1642303-38-5 MDL|1642303-38-5 SMILES|1642303-38-5 PDE1-IN-1 (phosphate)