Home Other Building Blocks 1782235-14-6
1782235-14-6,MFCD29079432
Catalog No.:AA00ABP9

1782235-14-6 | CHIR 99021 trihydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
≥98%(HPLC)
in stock  
$361.00   $253.00
- +
50mg
≥98%(HPLC)
in stock  
$1,200.00   $840.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABP9
Chemical Name:
CHIR 99021 trihydrochloride
CAS Number:
1782235-14-6
Molecular Formula:
C22H21Cl5N8
Molecular Weight:
574.7207
MDL Number:
MFCD29079432
SMILES:
N#Cc1ccc(nc1)NCCNc1ncc(c(n1)c1ccc(cc1Cl)Cl)c1ncc([nH]1)C.Cl.Cl.Cl
Properties
Computed Properties
 
Complexity:
645  
Covalently-Bonded Unit Count:
4  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
7  

Literature

Title: Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95.

Title: Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273.

Title: Ye S, et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012;7(4):e35892.

Title: Bennett CN, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002 Aug 23;277(34):30998-1004.

Title: Wang X, et al. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. Sci Rep. 2015 Apr 10;5:8566.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1782235-14-6
Tags:1782235-14-6 Molecular Formula|1782235-14-6 MDL|1782235-14-6 SMILES|1782235-14-6 CHIR 99021 trihydrochloride