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173529-10-7,MFCD00945108
Catalog No.:AA00ABPM

173529-10-7 | HMN-176

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$130.00   $91.00
- +
10mg
≥98%
in stock  
$248.00   $173.00
- +
25mg
≥98%
in stock  
$358.00   $250.00
- +
50mg
≥98%
in stock  
$649.00   $454.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00ABPM
Chemical Name:
HMN-176
CAS Number:
173529-10-7
Molecular Formula:
C20H18N2O4S
Molecular Weight:
382.4329
MDL Number:
MFCD00945108
SMILES:
COc1ccc(cc1)S(=O)(=O)N=C1C=CC=CC1=CC=c1ccn(cc1)O
Properties
Computed Properties
 
Complexity:
846  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
2  
Formal Charge:
0  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.4  

Downstream Synthesis Route
173529-10-7    3235-69-6   
CASUnavailable 
  541-41-3    345206-84-0 

[1]CurrentPatentAssignee:NIPPONSHINYAKUCOLTD-US2003/22884,2003,A1

Literature

Title: DiMaio MA, et al. The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation. Mol Cancer Ther. 2009 Mar;8(3):592-601.

Title: Medina-Gundrum L, et al. Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression. Invest New Drugs. 2005 Jan;23(1):3-9.

Title: Takagi M, et al. In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176. Invest New Drugs. 2003 Nov;21(4):387-99.

Title: Tanaka H, et al. HMN-176, an active metabolite of the synthetic antitumor agent HMN-214, restores chemosensitivity to multidrug-resistant cells by targeting the transcription factor NF-Y. Cancer Res. 2003 Oct 15;63(20):6942-7.

Title: Garland LL, et al. A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors. Clin Cancer Res. 2006 Sep 1;12(17):5182-9.

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Tags:173529-10-7 Molecular Formula|173529-10-7 MDL|173529-10-7 SMILES|173529-10-7 HMN-176
Catalog No.: AA00ABPM
173529-10-7,MFCD00945108
173529-10-7 | HMN-176
Pack Size： 5mg
Purity： ≥98%
in stock
$130.00 $91.00
Pack Size： 10mg
Purity： ≥98%
in stock
$248.00 $173.00
Pack Size： 25mg
Purity： ≥98%
in stock
$358.00 $250.00
Pack Size： 50mg
Purity： ≥98%
in stock
$649.00 $454.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00ABPM
Chemical Name: HMN-176
CAS Number: 173529-10-7
Molecular Formula: C20H18N2O4S
Molecular Weight: 382.4329
MDL Number: MFCD00945108
SMILES: COc1ccc(cc1)S(=O)(=O)N=C1C=CC=CC1=CC=c1ccn(cc1)O
Properties
Complexity: 846  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 2  
Formal Charge: 0  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.4  
Downstream Synthesis Route
173529-10-7    3235-69-6   
CASUnavailable 
  541-41-3    345206-84-0 

[1]CurrentPatentAssignee:NIPPONSHINYAKUCOLTD-US2003/22884,2003,A1

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