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1523406-39-4,MFCD28411361
Catalog No.:AA00ABQG

1523406-39-4 | SAR405

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$38.00   $27.00
- +
2mg
98+%
in stock  
$57.00   $40.00
- +
5mg
98+%
in stock  
$95.00   $67.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00ABQG
Chemical Name:
SAR405
CAS Number:
1523406-39-4
Molecular Formula:
C19H21ClF3N5O2
Molecular Weight:
443.8505
MDL Number:
MFCD28411361
SMILES:
Clc1cncc(c1)CN1c2nc(cc(=O)n2CC[C@H]1C(F)(F)F)N1CCOC[C@H]1C
Properties
Computed Properties
 
Complexity:
731  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
8  
Rotatable Bond Count:
3  
XLogP3:
2.2  

Literature

Title: A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy.

Journal: Nature chemical biology 20141201

Title: The study of physician extenders in primary care.

Journal: Health services research 19750101

Title: Ronan B, et al. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat Chem Biol. 2014 Dec;10(12):1013-9.

Title: Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. Autophagy. 2015 Apr 3;11(4):725-6.

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SDS
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