[1]ChemicalandPharmaceuticalBulletin,1980,vol.28,p.2850-2852
[1]Chemicalandpharmaceuticalbulletin,1989,vol.37,p.1919-1921
[2]Chemicalandpharmaceuticalbulletin,1989,vol.37,p.1919-1921
[1]LiebigsAnnalenderChemie,1984,p.929-938
[2]Bioscience,BiotechnologyandBiochemistry,2001,vol.65,p.1869-1871
[3]PhytochemicalAnalysis,2013,vol.24,p.424-435
[1]Tetrahedron,1997,vol.53,p.10725-10732
[2]Patent:US9096501,2015,B2.Locationinpatent:Page/Pagecolumn61
[3]AngewandteChemie-InternationalEdition,2015,vol.54,p.8217-8221 Angew.Chem.,2015,vol.127,p.8335-8339,5
[4]JournalofMedicinalChemistry,2006,vol.49,p.2829-2837
[5]ACSMedicinalChemistryLetters,2012,vol.3,p.631-636,6
[6]JournalofMedicinalChemistry,2014,vol.57,p.4805-4818
[1]Phytochemistry,1998,vol.49,p.327-332
Title: Reactive oxygen species-mediated activation of JNK and down-regulation of DAXX are critically involved in penta-O-galloyl-beta-d-glucose-induced apoptosis in chronic myeloid leukemia K562 cells.
Journal: Biochemical and biophysical research communications 20120803
Title: A review of animal and human studies for management of benign prostatic hyperplasia with natural products: perspective of new pharmacological agents.
Journal: Inflammation & allergy drug targets 20120601
Title: Hamamelitannin from witch hazel (Hamamelis virginiana) displays specific cytotoxic activity against colon cancer cells.
Journal: Journal of natural products 20120127
Title: Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: Involvement of iron in biofilm formation by Staphylococcus aureus.
Journal: PloS one 20120101
Title: A gallotannin-rich fraction from Caesalpinia spinosa (Molina) Kuntze displays cytotoxic activity and raises sensitivity to doxorubicin in a leukemia cell line.
Journal: BMC complementary and alternative medicine 20120101
Title: Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells.
Journal: Clinical and experimental gastroenterology 20120101
Title: Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells.
Journal: Apoptosis : an international journal on programmed cell death 20110901
Title: Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix.
Journal: Journal of ethnopharmacology 20110901
Title: The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: molecular target on cancer metabolism.
Journal: Molecules and cells 20110831
Title: 1,2,3,4,6-penta-O-galloyl-β-D-glucose, quercetin, curcumin and lycopene induce cell-cycle arrest in MDA-MB-231 and BT474 cells through downregulation of Skp2 protein.
Journal: Journal of agricultural and food chemistry 20110622
Title: Oral administration of penta-O-galloyl-β-D-glucose suppresses triple-negative breast cancer xenograft growth and metastasis in strong association with JAK1-STAT3 inhibition.
Journal: Carcinogenesis 20110601
Title: 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose reduces renal crystallization and oxidative stress in a hyperoxaluric rat model.
Journal: Kidney international 20110301
Title: Conformation of the tridimensional structure of 1,2,3,4,6-pentagalloyl-β-D-glucopyranose (PGG) by (1)H NMR, NOESY and theoretical study and membrane interaction in a simulated phospholipid bilayer: a first insight.
Journal: Magnetic resonance in chemistry : MRC 20110301
Title: A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin.
Journal: PloS one 20110101
Title: Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.
Journal: Journal of natural products 20100924
Title: Oenothera paradoxa defatted seeds extract and its bioactive component penta-O-galloyl-β-D-glucose decreased production of reactive oxygen species and inhibited release of leukotriene B4, interleukin-8, elastase, and myeloperoxidase in human neutrophils.
Journal: Journal of agricultural and food chemistry 20100922
Title: Intestinal alpha-glucosidase inhibitory activity and toxicological evaluation of Nymphaea stellata flowers extract.
Journal: Journal of ethnopharmacology 20100915
Title: Antioxidant effects of secondary metabolites from Geranium psilostemon.
Journal: Natural product communications 20100601
Title: Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos.
Journal: Bioorganic & medicinal chemistry letters 20100301
Title: Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.
Journal: Journal of Alzheimer's disease : JAD 20100101
Title: Effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on elastase and hyaluronidase activities and its type II collagen expression.
Journal: Acta poloniae pharmaceutica 20100101
Title: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose protects splenocytes against radiation-induced apoptosis in murine splenocytes.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Penta-O-galloyl-beta-D-glucose induces G1 arrest and DNA replicative S-phase arrest independently of cyclin-dependent kinase inhibitor 1A, cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth.
Journal: Breast cancer research : BCR 20100101
Title: 1,2,3,4,6-Penta-O-galloly-beta-D-glucose suppresses hypoxia-induced accumulation of hypoxia-inducible factor-1α and signaling in LNCaP prostate cancer cells.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts.
Journal: Tissue engineering. Part A 20091001
Title: Suppression of thymus- and activation-regulated chemokine (TARC/CCL17) production by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose via blockade of NF-kappaB and STAT1 activation in the HaCaT cells.
Journal: Biochemical and biophysical research communications 20090911
Title: [Chemical constituents from roots of Distylium myricoides].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090901
Title: Antioxidant and hepatoprotective activities of thai mango seed kernel extract.
Journal: Planta medica 20090801
Title: Melanogenesis inhibition by gallotannins from Chinese galls in B16 mouse melanoma cells.
Journal: Biological & pharmaceutical bulletin 20090801
Title: A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo.
Journal: Journal of neurochemistry 20090601
Title: Penta-O-galloyl-beta-D-glucose induces S- and G(1)-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1.
Journal: Carcinogenesis 20090501
Title: Penta-O-galloyl-beta-D-glucose suppresses prostate cancer bone metastasis by transcriptionally repressing EGF-induced MMP-9 expression.
Journal: Journal of agricultural and food chemistry 20090422
Title: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose attenuates renal cell migration, hyaluronan expression, and crystal adhesion.
Journal: European journal of pharmacology 20090315
Title: Tyrosinase inhibitors isolated from the roots of Paeonia suffruticosa.
Journal: Journal of cosmetic science 20090101
Title: Novel biological properties of Oenothera paradoxa defatted seed extracts: effects on metallopeptidase activity.
Journal: Journal of agricultural and food chemistry 20080910
Title: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose from Galla Rhois protects primary rat hepatocytes from necrosis and apoptosis.
Journal: Planta medica 20080901
Title: Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo.
Journal: Molecular cancer therapeutics 20080901
Title: Elaeocarpus sylvestris modulates gamma-ray-induced immunosuppression in mice: implications in radioprotection.
Journal: Phytotherapy research : PTR 20080801
Title: Antioxidative activity of geranium (Pelargonium inquinans Ait) and its active component, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose.
Journal: Phytotherapy research : PTR 20080401
Title: [Determination of 1, 2, 3, 4, 6-penta-O-galloyl-D-glucose in forty four kinds of Chinese traditional medicines by HPLC].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080301
Title: Bioactivity-guided isolation of the active compounds from Rosa nutkana and quantitative analysis of ascorbic acid by HPLC.
Journal: Canadian journal of physiology and pharmacology 20070901
Title: The isolation of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose from Acer truncatum Bunge by high-speed counter-current chromatography.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501
Title: Elastin stabilization for treatment of abdominal aortic aneurysms.
Journal: Circulation 20070403
Title: Protein binding and astringent taste of a polymeric procyanidin, 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose, castalagin, and grandinin.
Journal: Journal of agricultural and food chemistry 20061213
Title: In vitro antiviral activity of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose against hepatitis B virus.
Journal: Biological & pharmaceutical bulletin 20061001
Title: [Studies on HPLC fingerprint of cortex moutan].
Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001
Title: Synthesis and structure-activity relationship study of antidiabetic penta-O-galloyl-D-glucopyranose and its analogues.
Journal: Journal of medicinal chemistry 20060504
Title: 1,2,3,4,6-penta-O-galloyl-beta-D-glucose up-regulates heme oxygenase-1 expression by stimulating Nrf2 nuclear translocation in an extracellular signal-regulated kinase-dependent manner in HepG2 cells.
Journal: World journal of gastroenterology 20060114
Title: Role of peptide primary sequence in polyphenol-protein recognition: an example with neurotensin.
Journal: Biochimica et biophysica acta 20051130
Title: Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway.
Journal: European journal of pharmacology 20051107
Title: Phenolic constituents of galla Rhois with hepatoprotective effects on tacrine- and nitrofurantoin-induced cytotoxicity in Hep G2 cells.
Journal: Biological & pharmaceutical bulletin 20051101
Title: Natural anti-diabetic compound 1,2,3,4,6-penta-O-galloyl-D-glucopyranose binds to insulin receptor and activates insulin-mediated glucose transport signaling pathway.
Journal: Biochemical and biophysical research communications 20051021
Title: Enzymology of gallotannin and ellagitannin biosynthesis.
Journal: Phytochemistry 20050901
Title: Anticoagulant 1,2,3,4,6-pentagalloyl-beta-D-glucopyranose isolated from geranium (Pelargonium inquinans Ait).
Journal: Archives of pharmacal research 20050901
Title: Penta-O-galloyl-beta-D-glucose suppresses tumor growth via inhibition of angiogenesis and stimulation of apoptosis: roles of cyclooxygenase-2 and mitogen-activated protein kinase pathways.
Journal: Carcinogenesis 20050801
Title: Beta-secretase (BACE1) inhibitors from Sanguisorbae Radix.
Journal: Archives of pharmacal research 20050701
Title: Green tea: Health benefits as cancer preventive for humans.
Journal: Chemical record (New York, N.Y.) 20050101
Title: Chemical identification of the sources of commercial Fructus Chebulae.
Journal: Phytochemical analysis : PCA 20050101
Title: In vitro anti-HCV activities of Saxifraga melanocentra and its related polyphenolic compounds.
Journal: Antiviral chemistry & chemotherapy 20050101
Title: Antiviral compounds from traditional Chinese medicines Galla Chinese as inhibitors of HCV NS3 protease.
Journal: Bioorganic & medicinal chemistry letters 20041220
Title: Quantitative examination of oxidized polyphenol-protein complexes.
Journal: Journal of agricultural and food chemistry 20041006
Title: Theaflavin-3,3'-digallate and penta-O-galloyl-beta-D-glucose inhibit rat liver microsomal 5alpha-reductase activity and the expression of androgen receptor in LNCaP prostate cancer cells.
Journal: Carcinogenesis 20040701
Title: Characterization of soluble non-covalent complexes between bovine serum albumin and beta-1,2,3,4,6-penta-O-galloyl-D-glucopyranose by MALDI-TOF MS.
Journal: Journal of agricultural and food chemistry 20040616
Title: 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor.
Journal: Cancer letters 20040510
Title: Penta-O-galloyl-beta-D-glucose inhibits phorbol myristate acetate-induced interleukin-8 [correction of intereukin-8] gene expression in human monocytic U937 cells through its inactivation of nuclear factor-kappaB.
Journal: International immunopharmacology 20040301
Title: Novel lipid-peroxidation- and cyclooxygenase-inhibitory tannins from Picrorhiza kurroa seeds.
Journal: Chemistry & biodiversity 20040301
Title: Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose in murine macrophage cells.
Journal: Archives of pharmacal research 20031001
Title: Paeonianins A-E, new dimeric and monomeric ellagitannins from the fruits of Paeonia lactiflora.
Journal: Journal of natural products 20030601
Title: Oxidation of pentagalloylglucose to the ellagitannin, tellimagrandin II, by a phenol oxidase from Tellima grandiflora leaves.
Journal: Phytochemistry 20030201
Title: Inhibitory effects of the root cortex of Paeonia suffruticosa on interleukin-8 and macrophage chemoattractant protein-1 secretions in U937 cells.
Journal: Journal of ethnopharmacology 20030101
Title: Two new and four known polyphenolics obtained as new cell-cycle inhibitors from Rubus aleaefolius Poir.
Journal: Journal of Asian natural products research 20021201
Title: Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
Journal: Journal of natural products 20021201
Title: Gallotannin biosynthesis: two new galloyltransferases from Rhus typhina leaves preferentially acylating hexa- and heptagalloylglucoses.
Journal: Planta 20021101
Title: Penta-O-galloyl-beta-D-glucose inhibits the invasion of mouse melanoma by suppressing metalloproteinase-9 through down-regulation of activator protein-1.
Journal: European journal of pharmacology 20021025
Title: 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose protects rat neuronal cells (Neuro 2A) from hydrogen peroxide-mediated cell death via the induction of heme oxygenase-1.
Journal: Neuroscience letters 20020809
Title: Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis.
Journal: Planta medica 20020501
Title: Respiratory syncytial virus infection induces matrix metalloproteinase-9 expression in epithelial cells.
Journal: Archives of virology 20020101
Title: In vitro anti-proliferative effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on human hepatocellular carcinoma cell line, SK-HEP-1 cells.
Journal: Cancer letters 20011210
Title: Gallotannin biosynthesis: beta-glucogallin: hexagalloyl 3-O-galloyltransferase from Rhus typhina leaves.
Journal: Phytochemistry 20011101
Title: Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase.
Journal: Journal of natural products 20010801
Title: Ellagic acid formation from galloylglucoses by a crude enzyme of Cornus capitata adventitious roots.
Journal: Bioscience, biotechnology, and biochemistry 20010801
Title: Seasonal variation in the content of hydrolysable tannins in leaves of Betula pubescens.
Journal: Phytochemistry 20010501
Title: Prolyl endopeptidase inhibitors from the underground part of Rhodiola sachalinensis.
Journal: Chemical & pharmaceutical bulletin 20010401
Title: Inhibitory effects of ellagi- and gallotannins on rat intestinal alpha-glucosidase complexes.
Journal: Bioscience, biotechnology, and biochemistry 20010301
Title: Identification of hydrolysable tannins in the reaction zone of Eucalyptus nitens wood by high performance liquid chromatography--electrospray ionisation mass spectrometry.
Journal: Phytochemical analysis : PCA 20010101
Title: Induction of apoptosis by penta-O-galloyl-beta-D-glucose through activation of caspase-3 in human leukemia HL-60 cells.
Journal: European journal of pharmacology 19990924
Title: A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase.
Journal: Journal of natural products 19980101
Title: Sulfated pentagalloyl glucose (Y-ART-3) inhibits HIV replication and cytopathic effects in vitro, and reduces HIV infection in hu-PBL-SCID mice.
Journal: Antiviral research 19960501
Title: Inhibition of human immunodeficiency viral replication by tannins and related compounds.
Journal: Antiviral research 19920501
Title: Viswanatha GL, et al. Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica. Eur J Pharmacol. 2013 Nov 15;720(1-3):286-93.
Title: Kim YH, et al. 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mice. Int Immunopharmacol. 2015 May;26(1):30-6.
Title: Ahn D, et al. The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose from Curcuma longa in Caenorhabditis elegans. Biomol Ther (Seoul). 2013 Nov;21(6):442-6.
Title: Tu Z, et al. Pentagalloylglucose Inhibits the Replication of Rabies Virus via Mediation of the miR-455/SOCS3/STAT3/IL-6 Pathway. J Virol. 2019 Aug 28;93(18). pii: e00539-19.
