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161552-03-0,MFCD00937400
Catalog No.:AA00AOGW

161552-03-0 | CYCLO (ARG-GLY-ASP-D-PHE-LYS)

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5mg
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$173.00   $121.00
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10mg
≥95%
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$329.00   $230.00
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25mg
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$688.00   $481.00
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50mg
95%
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100mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AOGW
Chemical Name:
CYCLO (ARG-GLY-ASP-D-PHE-LYS)
CAS Number:
161552-03-0
Molecular Formula:
C29H42F3N9O9
Molecular Weight:
717.6939
MDL Number:
MFCD00937400
SMILES:
OC(=O)C(F)(F)F.NCCCCC1NC(=O)C(Cc2ccccc2)NC(=O)C(CC(=O)O)NC(=O)CNC(=O)C(NC1=O)CCCN=C(N)N
Properties
Computed Properties
 
Complexity:
1010  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
43  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
12  
XLogP3:
-4.7  

Downstream Synthesis Route
71989-14-5    86123-10-6    186350-56-1   
R(Pmc)-Glinearpeptideboundtoresin 
  161552-03-0 

[1]TetrahedronLetters,2001,vol.42,p.2787-2790

[1]ChemBioChem,2010,vol.11,p.2168-2181

[1]ChemBioChem,2010,vol.11,p.2168-2181

[1]Locationinpatent:experimentalpartJacobson,Orit;Zhu,Lei;Ma,Ying;Weiss,IdoD.;Sun,Xilin;Niu,Gang;Kiesewetter,DaleO.;Chen,Xiaoyuan[BioconjugateChemistry,2011,vol.22,#3,p.422-428]

[1]Guo,Yanyan;Yuan,Hushan;Rice,WilliamL.;Kumar,AnandT.N.;Goergen,CraigJ.;Jokivarsi,Kimmo;Josephson,Lee[JournaloftheAmericanChemicalSociety,2012,vol.134,#47,p.19338-19341]

Literature

Title: Failure of active targeting by a cholesterol-anchored ligand and improvement by altering the lipid composition to prevent ligand desorption.

Journal: International journal of pharmaceutics 20180130

Title: Tailored polymer-lipid hybrid nanoparticles for the delivery of drug conjugate: dual strategy for brain targeting.

Journal: Colloids and surfaces. B, Biointerfaces 20150201

Title: A cyclen-based tetraphosphinate chelator for the preparation of radiolabeled tetrameric bioconjugates.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20130610

Title: cRGD-functionalized polymeric magnetic nanoparticles as a dual-drug delivery system for safe targeted cancer therapy.

Journal: Pharmacological research 20130401

Title: Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery.

Journal: Organic & biomolecular chemistry 20130221

Title: Microfluidic radiolabeling of biomolecules with PET radiometals.

Journal: Nuclear medicine and biology 20130101

Title: Transferrin-modified c[RGDfK]-paclitaxel loaded hybrid micelle for sequential blood-brain barrier penetration and glioma targeting therapy.

Journal: Molecular pharmaceutics 20120604

Title: Microfluidic labeling of biomolecules with radiometals for use in nuclear medicine.

Journal: Lab on a chip 20101221

Title: Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: implications for tumor targeting and tumor imaging purposes.

Journal: Organic & biomolecular chemistry 20070321

Title: Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95.

Title: Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14.

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SDS
Tags:161552-03-0 Molecular Formula|161552-03-0 MDL|161552-03-0 SMILES|161552-03-0 CYCLO (ARG-GLY-ASP-D-PHE-LYS)