[1]Patent:WO2019/183403,2019,A1.Locationinpatent:Paragraph0028;00188-00189
[2]JournalofMedicinalChemistry,1995,vol.38,p.2418-2426
[1]Dodic,Nerina;Dumaitre,Bernard;Daugan,Alain;Pianetti,Pascal[JournalofMedicinalChemistry,1995,vol.38,#13,p.2418-2426]
[1]Dodic,Nerina;Dumaitre,Bernard;Daugan,Alain;Pianetti,Pascal[JournalofMedicinalChemistry,1995,vol.38,#13,p.2418-2426]
[2]CurrentPatentAssignee:IZUMITECHNOLOGYLLC-WO2019/183403,2019,A1
[1]Dodic,Nerina;Dumaitre,Bernard;Daugan,Alain;Pianetti,Pascal[JournalofMedicinalChemistry,1995,vol.38,#13,p.2418-2426]
[1]Dodic,Nerina;Dumaitre,Bernard;Daugan,Alain;Pianetti,Pascal[JournalofMedicinalChemistry,1995,vol.38,#13,p.2418-2426]
Title: Multiple drug transporters mediate the placental transport of sulpiride.
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Title: Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice.
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Title: Interaction Studies of Resolvin E1 Analog (RX-10045) with Efflux Transporters.
Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20150501
Title: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).
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Title: Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease.
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Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
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Title: Transport inhibition of digoxin using several common P-gp expressing cell lines is not necessarily reporting only on inhibitor binding to P-gp.
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Title: Oral availability and brain penetration of the B-RAFV600E inhibitor vemurafenib can be enhanced by the P-GLYCOprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar.
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Title: Active efflux of Dasatinib from the brain limits efficacy against murine glioblastoma: broad implications for the clinical use of molecularly targeted agents.
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Title: Pharmacokinetic modeling to assess factors affecting the oral bioavailability of the lactone and carboxylate forms of the lipophilic camptothecin analogue AR-67 in rats.
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Title: Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
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Title: Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists.
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Title: Stereoselective interaction of pantoprazole with ABCG2. I. Drug accumulation in rat milk.
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Title: Oral and inhaled corticosteroids: differences in P-glycoprotein (ABCB1) mediated efflux.
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Title: Investigation of chalcones as selective inhibitors of the breast cancer resistance protein: critical role of methoxylation in both inhibition potency and cytotoxicity.
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Title: Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
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Title: Understanding the interplay of drug transporters involved in the disposition of rosuvastatin in the isolated perfused rat liver using a physiologically-based pharmacokinetic model.
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Title: Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates.
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Title: Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.
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Title: Dual approach utilizing self microemulsifying technique and novel P-gp inhibitor for effective delivery of taxanes.
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Title: Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.
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Title: Solid phase synthesis of tariquidar-related modulators of ABC transporters preferring breast cancer resistance protein (ABCG2).
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Title: The bioflavonoid kaempferol is an Abcg2 substrate and inhibits Abcg2-mediated quercetin efflux.
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Title: Characterisation and manipulation of docetaxel resistant prostate cancer cell lines.
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Title: P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor.
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Title: The transport of gastrodin in Caco-2 cells and uptake in Bcap37 and Bcap37/MDR1 cells.
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Title: In vitro investigation of the hepatobiliary disposition mechanisms of the antifungal agent micafungin in humans and rats.
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Title: Hepatobiliary disposition of 3alpha,6alpha,7alpha,12alpha-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters.
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Title: In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption.
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Title: Examination of the ability of the nasal administration route to confer a brain exposure advantage for three chemical inhibitors of P-glycoprotein.
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Title: Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux.
Journal: The Journal of pharmacology and experimental therapeutics 20100701
Title: Toxicokinetics of the food-toxin IQ in human placental perfusion is not affected by ABCG2 or xenobiotic metabolism.
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Title: Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.
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Title: Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism.
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Title: Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier.
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Title: Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).
Journal: Bioorganic & medicinal chemistry letters 20100101
Title: The P-glycoprotein inhibitor GF120918 modulates Ca2+-dependent processes and lipid metabolism in Toxoplasma gondii.
Journal: PloS one 20100101
Title: Hepatitis C virus NS3 protease inhibitors: large, flexible molecules of peptide origin show satisfactory permeability across Caco-2 cells.
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Title: Investigation of the micellar effect of pluronic P85 on P-glycoprotein inhibition: cell accumulation and equilibrium dialysis studies.
Journal: Journal of pharmaceutical sciences 20091101
Title: Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers.
Journal: Journal of pharmaceutical sciences 20091101
Title: Decreased urinary secretion of belotecan in folic acid-induced acute renal failure rats due to down-regulation of Oat1 and Bcrp.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20091001
Title: Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20091001
Title: P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib.
Journal: The Journal of pharmacology and experimental therapeutics 20090901
Title: Identification of novel specific and general inhibitors of the three major human ATP-binding cassette transporters P-gp, BCRP and MRP2 among registered drugs.
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Title: Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.
Journal: Antimicrobial agents and chemotherapy 20090601
Title: Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by elacridar treatment.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090401
Title: In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [(11)C]gefitinib.
Journal: Nuclear medicine and biology 20090401
Title: Substrate-dependent breast cancer resistance protein (Bcrp1/Abcg2)-mediated interactions: consideration of multiple binding sites in in vitro assay design.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090301
Title: Potent and selective inhibitors of breast cancer resistance protein (ABCG2) derived from the p-glycoprotein (ABCB1) modulator tariquidar.
Journal: Journal of medicinal chemistry 20090226
Title: The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib.
Journal: Investigational new drugs 20090201
Title: Development and characterisation of a new model of rat trophoblasts.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090201
Title: Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes.
Journal: Chemical research in toxicology 20090101
Title: Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion.
Journal: Molecular pharmaceutics 20090101
Title: Molecular expression and functional evidence of a drug efflux pump (BCRP) in human corneal epithelial cells.
Journal: Current eye research 20090101
Title: 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties.
Journal: Journal of medicinal chemistry 20081211
Title: N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide (GF120918) as a chemical ATP-binding cassette transporter family G member 2 (Abcg2) knockout model to study nitrofurantoin transfer into milk.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201
Title: Apparent differences in mechanisms of harmol sulfate biliary excretion in mice and rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20081101
Title: A novel human multidrug resistance gene MDR1 variant G571A (G191R) modulates cancer drug resistance and efflux transport.
Journal: The Journal of pharmacology and experimental therapeutics 20081101
Title: Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080801
Title: Mechanisms underlying saturable intestinal absorption of metformin.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080801
Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Journal: Journal of medicinal chemistry 20080612
Title: Role of P-glycoprotein and the intestine in the excretion of DPC 333 [(2R)-2-{(3R)-3-amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in rodents.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080601
Title: Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice.
Journal: Journal of cancer research and clinical oncology 20080501
Title: Chemosensitivity determinants of irinotecan hydrochloride in hepatocellular carcinoma cell lines.
Journal: Basic & clinical pharmacology & toxicology 20080401
Title: 4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators.
Journal: Bioorganic & medicinal chemistry 20080401
Title: Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents.
Journal: Journal of medicinal chemistry 20080313
Title: Kinetic identification of membrane transporters that assist P-glycoprotein-mediated transport of digoxin and loperamide through a confluent monolayer of MDCKII-hMDR1 cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201
Title: P-glycoprotein restricts the penetration of oseltamivir across the blood-brain barrier.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201
Title: Multidrug resistance-associated protein 2 is primarily responsible for the biliary excretion of fexofenadine in mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080101
Title: Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives.
Journal: Bioorganic & medicinal chemistry 20080101
Title: P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101
Title: Placental transfer of quetiapine in relation to P-glycoprotein activity.
Journal: Journal of psychopharmacology (Oxford, England) 20070901
Title: Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridar.
Journal: Pharmaceutical research 20070901
Title: Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec) across the mouse blood-brain barrier.
Journal: Journal of neurochemistry 20070901
Title: Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701
Title: Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG.
Journal: British journal of pharmacology 20070701
Title: Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux.
Journal: British journal of pharmacology 20070701
Title: A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070601
Title: The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2).
Journal: British journal of pharmacology 20070501
Title: Acridone derivatives: design, synthesis, and inhibition of breast cancer resistance protein ABCG2.
Journal: Bioorganic & medicinal chemistry 20070415
Title: Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
Journal: Cancer chemotherapy and pharmacology 20070201
Title: Danofloxacin-mesylate is a substrate for ATP-dependent efflux transporters.
Journal: British journal of pharmacology 20070201
Title: The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models.
Journal: Molecular pharmacology 20070101
Title: Proteomic analysis to dissect mitoxantrone resistance-associated proteins in a squamous lung carcinoma.
Journal: Anticancer research 20070101
Title: An in vitro and in silico study on the flavonoid-mediated modulation of the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers.
Journal: Toxicology and applied pharmacology 20061201
Title: Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition.
Journal: Journal of medicinal chemistry 20061102
Title: Expression and transport activity of breast cancer resistance protein (Bcrp/Abcg2) in dually perfused rat placenta and HRP-1 cell line.
Journal: The Journal of pharmacology and experimental therapeutics 20061001
Title: Role of human placental efflux transporter P-glycoprotein in the transfer of buprenorphine, levo-alpha-acetylmethadol, and paclitaxel.
Journal: American journal of perinatology 20061001
Title: The complexity of intestinal absorption and exsorption of digoxin in rats.
Journal: International journal of pharmaceutics 20060928
Title: Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060701
Title: Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier.
Journal: The Journal of pharmacology and experimental therapeutics 20060601
Title: Comparison of drug efflux transport kinetics in various blood-brain barrier models.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060601
Title: Saturable absorptive transport of the hydrophilic organic cation ranitidine in Caco-2 cells: role of pH-dependent organic cation uptake system and P-glycoprotein.
Journal: Pharmaceutical research 20060601
Title: Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells.
Journal: Pharmaceutical research 20060601
Title: In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060501
Title: Interactions between the dopamine agonist, bromocriptine and the efflux protein, P-glycoprotein at the blood-brain barrier in the mouse.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060201
Title: Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo.
Journal: Clinical and experimental pharmacology & physiology 20060101
Title: Role of P-glycoprotein in the hepatic metabolism of tacrolimus.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20060101
Title: The steady-state Michaelis-Menten analysis of P-glycoprotein mediated transport through a confluent cell monolayer cannot predict the correct Michaelis constant Km.
Journal: Pharmaceutical research 20051001
Title: A combined cell based approach to identify P-glycoprotein substrates and inhibitors in a single assay.
Journal: International journal of pharmaceutics 20050914
Title: Multiple mechanisms are involved in the biliary excretion of acetaminophen sulfate in the rat: role of Mrp2 and Bcrp1.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: Functional role of P-glycoprotein in the human blood-placental barrier.
Journal: Clinical pharmacology and therapeutics 20050801
Title: The impact of pharmacologic and genetic knockout of P-glycoprotein on nelfinavir levels in the brain and other tissues in mice.
Journal: Journal of pharmaceutical sciences 20050601
Title: Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.
Journal: Cancer research 20050601
Title: Expression, localization, and functional characteristics of breast cancer resistance protein in Caco-2 cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050501
Title: The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients.
Journal: Cancer research 20050401
Title: P-glycoprotein and mutlidrug resistance-associated proteins limit the brain uptake of saquinavir in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20050301
Title: Differential sensitivities of the human ATP-binding cassette transporters ABCG2 and P-glycoprotein to cyclosporin A.
Journal: Molecular pharmacology 20050301
Title: Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050301
Title: Investigation of efflux transport of dehydroepiandrosterone sulfate and mitoxantrone at the mouse blood-brain barrier: a minor role of breast cancer resistance protein.
Journal: The Journal of pharmacology and experimental therapeutics 20050101
Title: Hepatobiliary disposition of the metabolically stable opioid peptide [D-Pen2, D-Pen5]-enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems.
Journal: The Journal of pharmacology and experimental therapeutics 20041201
Title: Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041001
Title: Quantitative analysis of the P-glycoprotein inhibitor Elacridar (GF120918) in human and dog plasma using liquid chromatography with tandem mass spectrometric detection.
Journal: Journal of mass spectrometry : JMS 20041001
Title: Preclinical pharmacokinetic properties of the P-glycoprotein inhibitor GF120918A (HCl salt of GF120918, 9,10-dihydro-5-methoxy-9-oxo-N-[4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]phenyl]-4-acridine-carboxamide) in the mouse, rat, dog, and monkey.
Journal: The Journal of pharmacology and experimental therapeutics 20040801
Title: Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice.
Journal: Investigational new drugs 20040801
Title: Differentiation of gut and hepatic first pass metabolism and secretion of saquinavir in ported rabbits.
Journal: The Journal of pharmacology and experimental therapeutics 20040701
Title: The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040701
Title: P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro.
Journal: Pharmaceutical research 20040701
Title: Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein.
Journal: European journal of cancer (Oxford, England : 1990) 20040501
Title: Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice.
Journal: British journal of pharmacology 20040401
Title: Flavonoid permeability across an in situ model of the blood-brain barrier.
Journal: Free radical biology & medicine 20040301
Title: Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells.
Journal: Molecular pharmaceutics 20040112
Title: Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A.
Journal: International journal of cancer 20031210
Title: Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20031101
Title: Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030701
Title: Effect of efflux inhibition on brain uptake of itraconazole in mice infected with Cryptococcus neoformans.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030301
Title: Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir.
Journal: The Journal of pharmacology and experimental therapeutics 20030201
Title: A novel inhibitor of multidrug efflux pumps in Staphylococcus aureus.
Journal: The Journal of antimicrobial chemotherapy 20030101
Title: Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model.
Journal: The Journal of pharmacology and experimental therapeutics 20021101
Title: MDR1 modulators improve the chemotherapy response of human hepatoblastoma to doxorubicin in vitro.
Journal: Journal of pediatric surgery 20021101
Title: Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity.
Journal: British journal of cancer 20020909
Title: Boosting bioavailability of topotecan: what do we gain?
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020701
Title: Increased oral bioavailability of topotecan in combination with the breast cancer resistance protein and P-glycoprotein inhibitor GF120918.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020701
Title: Effects of a P-glycoprotein inhibitor on brain and plasma concentrations of anti-human immunodeficiency virus drugs administered in combination in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020501
Title: A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance.
Journal: Cancer research 20020415
Title: Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT).
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020401
Title: Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.
Journal: The Journal of pharmacology and experimental therapeutics 20020301
Title: Anti-secretory properties of non-peptide somatostatin receptor agonists in isolated rat colon: luminal activity and possible interaction with P-glycoprotein.
Journal: British journal of pharmacology 20020301
Title: Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei.
Journal: Journal of natural products 20011201
Title: Bioanalysis and preliminary pharmacokinetics of the acridonecarboxamide derivative GF120918 in plasma of mice and humans by ion-pairing reversed-phase high-performance liquid chromatography with fluorescence detection.
Journal: Journal of chromatography. B, Biomedical sciences and applications 20010805
Title: Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010401
Title: Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice.
Journal: Pharmaceutical research 20010201
Title: In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.
Journal: Cancer research 20010115
Title: Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines.
Journal: Bioorganic & medicinal chemistry letters 20010108
Title: Co-administration of GF120918 significantly increases the systemic exposure to oral paclitaxel in cancer patients.
Journal: British journal of cancer 20010101
