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21411-53-0,MFCD00869411
Catalog No.:AA00BC1D

21411-53-0 | VIRGINIAMYCIN M1

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5mg
≥95%
in stock  
$496.00   $347.00
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25mg
≥95%
in stock  
$1,729.00   $1,210.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BC1D
Chemical Name:
VIRGINIAMYCIN M1
CAS Number:
21411-53-0
Molecular Formula:
C28H35N3O7
Molecular Weight:
525.5934
MDL Number:
MFCD00869411
SMILES:
O=C1NC/C=C\C(=C\[C@@H](O)CC(=O)Cc2nc(C(=O)N3C(=CCC3)C(=O)O[C@@H]([C@@H](/C=C/1)C)C(C)C)co2)\C
NSC Number:
87434
Properties
Computed Properties
 
Complexity:
1030  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
3  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
2.5  

Literature

Title: In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates.

Journal: International journal of antimicrobial agents 20111001

Title: Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump.

Journal: International journal of antimicrobial agents 20110701

Title: NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA.

Journal: Current opinion in investigational drugs (London, England : 2000) 20100201

Title: Characterization of pACK4, a mobilizable plasmid from Staphylococcus simulans biovar staphylolyticus.

Journal: Plasmid 20091101

Title: ATP hydrolysis and pristinamycin IIA inhibition of the Staphylococcus aureus Vga(A), a dual ABC protein involved in streptogramin A resistance.

Journal: The Journal of biological chemistry 20080912

Title: Evidence of a conjugal erythromycin resistance element in the Lyme disease spirochete Borrelia burgdorferi.

Journal: International journal of antimicrobial agents 20071201

Title: In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes.

Journal: Folia microbiologica 20070101

Title: The conformational flexibility of the antibiotic virginiamycin M(1).

Journal: European biophysics journal : EBJ 20050701

Title: A new phenotype of resistance to lincosamide and streptogramin A-type antibiotics in Streptococcus agalactiae in New Zealand.

Journal: The Journal of antimicrobial chemotherapy 20041201

Title: Solvent affects the conformation of virginiamycin M1 (pristinamycin IIA, streptogramin A).

Journal: Organic & biomolecular chemistry 20041021

Title: Streptogramin resistance among Enterococcus faecium isolated from production animals in Denmark in 1997.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20020101

Title: Sezonov G, et al. Complete conversion of antibiotic precursor to pristinamycin IIA by overexpression of Streptomyces pristinaespiralis biosynthetic genes. Nat Biotechnol. 1997 Apr;15(4):349-53.

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