Title: Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation.
Journal: PloS one 20160101
Title: Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
Journal: Chemico-biological interactions 20141205
Title: In vitro metabolism of testosterone in the horse liver and involvement of equine CYPs 3A89, 3A94 and 3A95.
Journal: Journal of veterinary pharmacology and therapeutics 20140801
Title: Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130201
Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Journal: Bioorganic & medicinal chemistry 20121115
Title: Time-dependent inhibition and estimation of CYP3A clinical pharmacokinetic drug-drug interactions using plated human cell systems.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20120701
Title: Pharmacokinetic and pharmacodynamic interaction between nifedipine and metformin in rats: competitive inhibition for metabolism of nifedipine and metformin by each other via CYP isozymes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20120501
Title: Absence of membrane phosphatidylcholine does not affect virulence and stress tolerance phenotypes in the opportunistic pathogen Pseudomonas aeruginosa.
Journal: PloS one 20120101
Title: The role of macrolides in childhood non-cystic fibrosis-related bronchiectasis.
Journal: Mediators of inflammation 20120101
Title: Macrolides in chronic inflammatory skin disorders.
Journal: Mediators of inflammation 20120101
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111101
Title: Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20111101
Title: Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes.
Journal: Journal of veterinary pharmacology and therapeutics 20111001
Title: In vitro metabolism of the mycotoxin enniatin B in different species and cytochrome p450 enzyme phenotyping by chemical inhibitors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110901
Title: Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes.
Journal: Chemical research in toxicology 20110815
Title: Cholesterol 25-hydroxylation activity of CYP3A.
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Title: Comparison of the substrate kinetics of pig CYP3A29 with pig liver microsomes and human CYP3A4.
Journal: Bioscience reports 20110601
Title: Casopitant: in vitro data and SimCyp simulation to predict in vivo metabolic interactions involving cytochrome P450 3A4.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110301
Title: CYP4F enzymes are responsible for the elimination of fingolimod (FTY720), a novel treatment of relapsing multiple sclerosis.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201
Title: Mechanism of cytochrome P450-3A inhibition by ketoconazole.
Journal: The Journal of pharmacy and pharmacology 20110201
Title: In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs.
Journal: Toxicology 20110111
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Participation of CYP2C8 and CYP3A4 in the N-demethylation of imatinib in human hepatic microsomes.
Journal: British journal of pharmacology 20101101
Title: [Metabolism of 3-cyanomethyl-4-methyl-DCK, a new anti-HIV candidate, in human intestinal microsomes].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100901
Title: Antiepileptic drug interactions - principles and clinical implications.
Journal: Current neuropharmacology 20100901
Title: Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701
Title: CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20100101
Title: Species differences in mechanism-based inactivation of CYP3A in humans, rats and mice.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodenafil and SK3541.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101
Title: A method for selecting cis-acting regulatory sequences that respond to small molecule effectors.
Journal: BMC molecular biology 20100101
Title: [Effect of CYP3A and P-glycoprotein on the absorption of buagafuran in rat intestinal lumen].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100101
Title: Recommendation for optimal management of severe refractory asthma.
Journal: Journal of asthma and allergy 20100101
Title: Prediction of human drug-drug interactions from time-dependent inactivation of CYP3A4 in primary hepatocytes using a population-based simulator.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20091201
Title: Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo.
Journal: The Journal of pharmacy and pharmacology 20091201
Title: Cytochrome P(450)-dependent toxic effects of primaquine on human erythrocytes.
Journal: Toxicology and applied pharmacology 20091115
Title: 5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).
Journal: Journal of medicinal chemistry 20091008
Title: [Metabolism of osthol in isolated hepatocytes of rat].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20091001
Title: Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.
Journal: Chemical research in toxicology 20090901
Title: Hyphenated ultra high-performance liquid chromatography-Nano Quantity Analyte Detector technique for determination of compounds with low UV absorption.
Journal: Journal of chromatography. A 20090724
Title: As in humans, pregnancy increases the clearance of the protease inhibitor nelfinavir in the nonhuman primate Macaca nemestrina.
Journal: The Journal of pharmacology and experimental therapeutics 20090601
Title: Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090601
Title: Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090601
Title: Antimicrobial resistance induced by genetic changes.
Journal: Journal of medicine and life 20090415
Title: CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090401
Title: Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism.
Journal: The Journal of pharmacy and pharmacology 20090101
Title: Indiplon in the management of insomnia.
Journal: Drug design, development and therapy 20090101
Title: Bama miniature pigs (Sus scrofa domestica) as a model for drug evaluation for humans: comparison of in vitro metabolism and in vivo pharmacokinetics of lovastatin.
Journal: Comparative medicine 20081201
Title: Determination of macrolide antibiotics in meat and fish using pressurized liquid extraction and liquid chromatography-mass spectrometry.
Journal: Journal of chromatography. A 20081024
Title: Role of biotransformation in 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione-induced hepatotoxicity in Fischer 344 rats.
Journal: Toxicology 20080904
Title: Identification of enzymes involved in the metabolism of 17alpha-hydroxyprogesterone caproate: an effective agent for prevention of preterm birth.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080901
Title: Role of macrolide therapy in chronic obstructive pulmonary disease.
Journal: International journal of chronic obstructive pulmonary disease 20080901
Title: Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080801
Title: A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080801
Title: Effects of cytochrome P450 (CYP) inducers and inhibitors on ondansetron pharmacokinetics in rats: involvement of hepatic CYP2D subfamily and 3A1/2 in ondansetron metabolism.
Journal: The Journal of pharmacy and pharmacology 20080701
Title: Indolealkylamines: biotransformations and potential drug-drug interactions.
Journal: The AAPS journal 20080601
Title: Role of CYP2B6 in stereoselective human methadone metabolism.
Journal: Anesthesiology 20080301
Title: Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU.
Journal: The Journal of pharmacy and pharmacology 20080101
Title: Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli.
Journal: Molecular microbiology 20071101
Title: [Carbamazepine and clarithromycin: a clinically relevant drug interaction].
Journal: Revue neurologique 20071101
Title: Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?
Journal: Biochemistry 20070703
Title: Role of CYP3A and CYP2E1 in alcohol-mediated increases in acetaminophen hepatotoxicity: comparison of wild-type and Cyp2e1(-/-) mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701
Title: In vitro metabolism of indiplon and an assessment of its drug interaction potential.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070701
Title: Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070501
Title: Pharmacokinetic and pharmacodynamic consequences of inhibition of terazosin metabolism via CYP3A1 and/or 3A2 by DA-8159, an erectogenic, in rats.
Journal: British journal of pharmacology 20070501
Title: Enantiomeric metabolic interactions and stereoselective human methadone metabolism.
Journal: The Journal of pharmacology and experimental therapeutics 20070401
Title: Safety of anti-immunoglobulin E therapy with omalizumab in allergic patients at risk of geohelminth infection.
Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070201
Title: Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats.
Journal: BMC bioinformatics 20070101
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of metformin in rats: involvement of CYP2C11, 2D1 and 3A1/2 for the metabolism of metformin.
Journal: British journal of pharmacology 20061001
Title: Investigation of the hepatotoxicity profile of chemical entities using Liverbeads and WIF-B9 in vitro models.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20060901
Title: Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060801
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous omeprazole in rats.
Journal: Biopharmaceutics & drug disposition 20060701
Title: Pharmacokinetic consequences of time-dependent inhibition using the isolated perfused rat liver model.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20060501
Title: Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats.
Journal: Biopharmaceutics & drug disposition 20060401
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous ipriflavone in rats.
Journal: The Journal of pharmacy and pharmacology 20060401
Title: Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate.
Journal: European journal of clinical pharmacology 20060301
Title: Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia.
Journal: Molecular pharmacology 20060101
Title: Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060101
Title: Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101
Title: Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.
Journal: Clinical pharmacology and therapeutics 20051101
Title: [Metabolic kinetics of MN9202 in Beagle dog liver microsomes].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20051101
Title: Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine.
Journal: Fundamental & clinical pharmacology 20051001
Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Journal: Current drug metabolism 20051001
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous DA-8159, a new erectogenic, in rats.
Journal: Biopharmaceutics & drug disposition 20050901
Title: Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801
Title: Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050801
Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous torasemide in rats.
Journal: International journal of pharmaceutics 20050714
Title: Metabolic activation of a pentafluorophenylethylamine derivative: formation of glutathione conjugates in vitro in the rat.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050701
Title: Evaluation of time-dependent inactivation of CYP3A in cryopreserved human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050601
Title: Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050601
Title: Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20050601
Title: Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo.
Journal: International journal of environmental research and public health 20050501
Title: Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats.
Journal: The Journal of pharmacy and pharmacology 20050401
Title: Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
Journal: Toxicology letters 20050315
Title: Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20050301
Title: Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.
Journal: Anesthesiology 20050301
Title: A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
Journal: The AAPS journal 20050301
Title: Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4.
Journal: Therapeutics and clinical risk management 20050301
Title: Metabolism of territrem B and C in liver microsomes from 14-wk-old Wistar rats is catalyzed by cytochrome P-450 3A.
Journal: Journal of toxicology and environmental health. Part A 20050227
Title: Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050215
Title: CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.
Journal: The Journal of clinical endocrinology and metabolism 20050201
Title: Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies.
Journal: Clinical pharmacokinetics 20050101
Title: Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomes.
Journal: European journal of drug metabolism and pharmacokinetics 20050101
Title: Eplerenone: the evidence for its place in the treatment of heart failure after myocardial infarction.
Journal: Core evidence 20050101
Title: Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20041101
Title: Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
Journal: Clinical pharmacology and therapeutics 20041101
Title: [Mechanism of mono-hydroxylation of daidzein in human liver microsomes].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20041101
Title: Oral erythromycin and the risk of sudden death from cardiac causes.
Journal: The New England journal of medicine 20040909
Title: CYP3A induction aggravates endotoxemic liver injury via reactive oxygen species in male rats.
Journal: Free radical biology & medicine 20040901
Title: Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro.
Journal: British journal of clinical pharmacology 20040901
Title: Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate.
Journal: Anesthesiology 20040901
Title: Pharmacokinetics of clarithromycin in rats with acute renal failure induced by uranyl nitrate.
Journal: Biopharmaceutics & drug disposition 20040901
Title: Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.
Journal: Clinical pharmacology and therapeutics 20040901
Title: Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats.
Journal: Chemical research in toxicology 20040901
Title: Different in vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs, and minipigs.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040601
Title: Relationship between content and activity of cytochrome P450 and induction of heterocyclic amine DNA adducts in human liver samples in vivo and in vitro.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040601
Title: Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro.
Journal: European journal of clinical pharmacology 20040501
Title: CYP3A4 is a human microsomal vitamin D 25-hydroxylase.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401
Title: Key structural features of ligands for activation of human pregnane X receptor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040401
Title: Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040401
Title: Biochemical background of toxic interaction between tiamulin and monensin.
Journal: Chemico-biological interactions 20040315
Title: Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040301
Title: CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes.
Journal: British journal of clinical pharmacology 20040301
Title: Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).
Journal: Chemical research in toxicology 20040301
Title: Immunomodulatory activity and effectiveness of macrolides in chronic airway disease.
Journal: Chest 20040201
Title: Utility of microtiter plate assays for human cytochrome P450 inhibition studies in drug discovery: application of simple method for detecting quasi-irreversible and irreversible inhibitors.
Journal: Drug metabolism and pharmacokinetics 20040201
Title: Large interindividual variability in the in vitro formation of tamoxifen metabolites related to the development of genotoxicity.
Journal: British journal of clinical pharmacology 20040101
Title: Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040101
Title: High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040101
Title: Active tamoxifen metabolite plasma concentrations after coadministration of tamoxifen and the selective serotonin reuptake inhibitor paroxetine.
Journal: Journal of the National Cancer Institute 20031203
Title: Macrolides as biological response modifiers in cystic fibrosis and bronchiectasis.
Journal: Seminars in respiratory and critical care medicine 20031201
Title: Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.
Journal: British journal of cancer 20031117
Title: Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031101
Title: Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20031101
Title: Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
Journal: European journal of biochemistry 20030901
Title: An evaluation of a low-density DNA microarray using cytochrome P450 inducers.
Journal: Chemical research in toxicology 20030901
Title: Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.
Journal: Journal of medicinal chemistry 20030828
Title: Evidence for the involvement of human liver microsomes CYP1A2 in the mono-hydroxylation of daidzein.
Journal: Clinica chimica acta; international journal of clinical chemistry 20030801
Title: Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030801
Title: Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030701
Title: The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6.
Journal: British journal of clinical pharmacology 20030701
Title: In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030601
Title: Upregulation of cytochromes P450 2B in rat liver by orphenadrine.
Journal: British journal of pharmacology 20030601
Title: Structural insight into the role of the ribosomal tunnel in cellular regulation.
Journal: Nature structural biology 20030501
Title: Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030501
Title: Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
Journal: Anesthesiology 20030401
Title: Alternate treatments in asthma.
Journal: Chest 20030401
Title: Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030401
Title: Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir.
Journal: The Journal of pharmacy and pharmacology 20030301
Title: TNF-alpha -induced endothelial cell adhesion molecule expression is cytochrome P-450 monooxygenase dependent.
Journal: American journal of physiology. Cell physiology 20030201
Title: Inhibitory effect of troleandomycin on the metabolism of omeprazole is CYP2C19 genotype-dependent.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030201
Title: Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: a new drug-drug interaction.
Journal: Circulation 20030107
Title: Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer.
Journal: Archives of biochemistry and biophysics 20030101
Title: High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry.
Journal: Journal of pharmaceutical and biomedical analysis 20030101
Title: Human liver microsomal metabolism and DNA adduct formation of the tumorigenic pyrrolizidine alkaloid, riddelliine.
Journal: Chemical research in toxicology 20030101
Title: CYP isoforms involved in the metabolism of clarithromycin in vitro: comparison between the identification from disappearance rate and that from formation rate of metabolites.
Journal: Drug metabolism and pharmacokinetics 20030101
Title: Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201
Title: Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201
Title: Effects of olopatadine, a new antiallergic agent, on human liver microsomal cytochrome P450 activities.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201
Title: Effect of caffeine on acetaminophen hepatotoxicity in cultured hepatocytes treated with ethanol and isopentanol.
Journal: Toxicology and applied pharmacology 20021201
Title: Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?
Journal: British journal of clinical pharmacology 20021201
Title: Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20021201
Title: Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin.
Journal: Clinical pharmacology and therapeutics 20021101
Title: Interaction of cytochrome P450 3A inhibitors with P-glycoprotein.
Journal: The Journal of pharmacology and experimental therapeutics 20021001
Title: CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020701
Title: Involvement of cytochrome P450 in the metabolism of rebamipide by the human liver.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020701
Title: Paraquat detoxicative system in the mouse liver postmitochondrial fraction.
Journal: Archives of biochemistry and biophysics 20020601
Title: Metabolism of a novel phosphodiesterase-IV inhibitor (V11294) by human hepatic cytochrome P450 forms.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020601
Title: Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Journal: Molecular pharmacology 20020501
Title: In vitro metabolic characteristics of cytochrome P-450 2A6 in Chinese liver microsomes.
Journal: Acta pharmacologica Sinica 20020501
Title: CYP3A4 active site volume modification by mutagenesis of leucine 211.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020401
Title: Identification of a novel route of extraction of sirolimus in human small intestine: roles of metabolism and secretion.
Journal: The Journal of pharmacology and experimental therapeutics 20020401
Title: Factors contributing to carbamazepine-macrolide interactions.
Journal: Pharmacological research 20020401
Title: The gastroprokinetic and antiemetic drug metoclopramide is a substrate and inhibitor of cytochrome P450 2D6.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020301
Title: Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids.
Journal: Biochemical pharmacology 20020301
Title: O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes.
Journal: The Journal of pharmacology and experimental therapeutics 20020101
Title: Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine.
Journal: Drug metabolism and pharmacokinetics 20020101
Title: Species difference in nisoldipine oxidation activity in the small intestine.
Journal: Drug metabolism and pharmacokinetics 20020101
Title: Major cytochrome P450 enzymes responsible for microsomal aldehyde oxygenation of 11-oxo-Delta8-tetrahydrocannabinol and 9-anthraldehyde in human liver.
Journal: Drug metabolism and pharmacokinetics 20020101
Title: A pilot evaluation of alfentanil-induced miosis as a noninvasive probe for hepatic cytochrome P450 3A4 (CYP3A4) activity in humans.
Journal: Clinical pharmacology and therapeutics 20011201
Title: Diazinon is activated by CYP2C19 in human liver.
Journal: Toxicology and applied pharmacology 20011115
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Title: Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A.
Journal: The Journal of pharmacology and experimental therapeutics 20010801
Title: Halothane-dependent lipid peroxidation in human liver microsomes is catalyzed by cytochrome P4502A6 (CYP2A6).
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Title: Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction.
Journal: Biochemical pharmacology 20010715
Title: Indirect cytotoxicity of flucloxacillin toward human biliary epithelium via metabolite formation in hepatocytes.
Journal: Chemical research in toxicology 20010601
Title: Nefiracetam metabolism by human liver microsomes: role of cytochrome P450 3A4 and cytochrome P450 1A2 in 5-hydroxynefiracetam formation.
Journal: The Journal of pharmacy and pharmacology 20010601
Title: Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions.
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Title: Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s.
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Title: Metabolism of levo-alpha-Acetylmethadol (LAAM) by human liver cytochrome P450: involvement of CYP3A4 characterized by atypical kinetics with two binding sites.
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Title: Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) in isolated rat hepatocytes.
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Title: Cytochrome P4502B6 and 2C9 do not metabolize midazolam: kinetic analysis and inhibition study with monoclonal antibodies.
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Title: Species difference in stereoselective involvement of CYP3A in the mono-N-dealkylation of disopyramide.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010201
Title: Bioactivation to free radicals and cytotoxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b).
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Title: Role of cytochrome P450 in estradiol metabolism in vitro.
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Title: Newer and alternative non-steroidal treatments for asthmatic inflammation.
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