Title: ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.
Journal: Journal of medicinal chemistry 20120112
Title: Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20091101
Title: A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model.
Journal: Journal of neuroinflammation 20070101
Title: 3-Benzidino-6(4-chlorophenyl) pyridazine blocks delayed rectifier and transient outward potassium current in acutely isolated rat hippocampal pyramidal neurons.
Journal: Neuroscience letters 20060710
Title: Selective optimization of side activities: another way for drug discovery.
Journal: Journal of medicinal chemistry 20040311
Title: Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6.
Journal: Bioorganic & medicinal chemistry 20031201
Title: An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury.
Journal: Bioorganic & medicinal chemistry letters 20031020
Title: Toxic cocaine- and convulsant-induced modification of forced swimming behaviors and their interaction with ethanol: comparison with immobilization stress.
Journal: BMC pharmacology 20020101
Title: Pharmacological evaluation of minaprine dihydrochloride, a new psychotropic drug.
Journal: Arzneimittel-Forschung 19820101
Title: Kan JP, et al. Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat. Biochem Pharmacol. 1986 Mar 15;35(6):973-8.
Title: Contreras JM, et al. Aminopyridazines as acetylcholinesterase inhibitors. J Med Chem. 1999 Feb 25;42(4):730-41.
