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248282-01-1,MFCD18633277
Catalog No.:AA00BJKV

248282-01-1 | Paquinimod

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$27.00   $19.00
- +
5mg
97%
in stock  
$68.00   $48.00
- +
10mg
97%
in stock  
$101.00   $71.00
- +
50mg
97%
in stock  
$284.00   $199.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BJKV
Chemical Name:
Paquinimod
CAS Number:
248282-01-1
Molecular Formula:
C21H22N2O3
Molecular Weight:
350.4110
MDL Number:
MFCD18633277
SMILES:
CCN(C(=O)c1c(O)c2c(CC)cccc2n(c1=O)C)c1ccccc1
Properties
Computed Properties
 
Complexity:
580  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
3.8  

Literature

Title: Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus.

Journal: Arthritis and rheumatism 20120501

Title: Specific effect of immunomodulatory quinoline-3-carboxamide ABR-215757 in GM-CSF stimulated bone marrow cell cultures: block of initiation of proliferation of Gr-1+ cells.

Journal: International immunopharmacology 20110801

Title: The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus.

Journal: International immunopharmacology 20041101

Title: Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship.

Journal: Journal of medicinal chemistry 20040408

Title: Schelbergen RF, et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis. 2015 Dec;74(12):2254-8.

Title: Tahvili S, et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse. PLoS One. 2018 May 9;13(5):e0196598.

Title: Qirui Guo, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021 Feb 10;29(2):222-235.e4.

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SDS
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