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31884-77-2,MFCD00941489
Catalog No.:AA00BY07

31884-77-2 | MECLIZINE HYDROCHLORIDE (500 MG)

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5mg
>99%(HPLC)
in stock  
$43.00   $30.00
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25mg
>99%(HPLC)
in stock  
$78.00   $55.00
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100mg
>99%(HPLC)
in stock  
$162.00   $114.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BY07
Chemical Name:
MECLIZINE HYDROCHLORIDE (500 MG)
CAS Number:
31884-77-2
Molecular Formula:
C25H30Cl2N2O
Molecular Weight:
445.4245
MDL Number:
MFCD00941489
SMILES:
Clc1ccc(cc1)C(c1ccccc1)N1CCN(CC1)Cc1cccc(c1)C.O.Cl
Properties
Computed Properties
 
Complexity:
448  
Covalently-Bonded Unit Count:
4  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  

Literature

Title: Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A.

Journal: Biochemical pharmacology 20151001

Title: Evaluation of teratogenic effects of risperidone following simultaneous administration with antihypertensive and antiemetic drugs.

Journal: Pakistan journal of pharmaceutical sciences 20120101

Title: Pharmaceutical countermeasures have opposite effects on the utricles and semicircular canals in man.

Journal: Audiology & neuro-otology 20120101

Title: No effects of anti-motion sickness drugs on vestibular evoked myogenic potentials outcome parameters.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20110401

Title: Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20110301

Title: Helix 11 dynamics is critical for constitutive androstane receptor activity.

Journal: Structure (London, England : 1993) 20110112

Title: Quantification of meclizine in human plasma by high performance liquid chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110101

Title: Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis.

Journal: Nature biotechnology 20100301

Title: Biphasic dosing regimen of meclizine for prevention of postoperative nausea and vomiting in a high-risk population.

Journal: AANA journal 20100201

Title: Withdrawal symptoms after discontinuation of transdermal scopolamine therapy: treatment with meclizine.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091115

Title: Vertigo - part 2 - management in general practice.

Journal: Australian family physician 20080601

Title: Induction of apoptosis and cell-cycle arrest in human colon cancer cells by meclizine.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070601

Title: Spectrophotometric methods for the simultaneous analysis of meclezine hydrochloride and pyridoxine hydrochloride in bulk drug and pharmaceutical formulations.

Journal: Pakistan journal of pharmaceutical sciences 20070401

Title: Airsickness prevention in helicopter passengers.

Journal: Aviation, space, and environmental medicine 20070401

Title: Meclizine in combination with ondansetron for prevention of postoperative nausea and vomiting in a high-risk population.

Journal: AANA journal 20070201

Title: Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).

Journal: Drug metabolism reviews 20060101

Title: Motion-sickness medications for aircrew: impact on psychomotor performance.

Journal: Aviation, space, and environmental medicine 20050601

Title: Auditory hallucinations elicited by combined meclizine and metaxalone use at bedtime.

Journal: The Annals of pharmacotherapy 20041101

Title: Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.

Journal: Molecular endocrinology (Baltimore, Md.) 20041001

Title: Stimulation of the semicircular canals via the rotary chair as a means to test pharmacologic countermeasures for space motion sickness.

Journal: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 20040901

Title: The successful use of meclizine in panic disorder.

Journal: The Journal of clinical psychiatry 20040901

Title: Effects of drug countermeasures for space motion sickness on working memory in humans.

Journal: Neurotoxicology and teratology 20040101

Title: Quantitative enantiomeric analysis of chlorcyclizine, hydroxyzine, and meclizine by capillary electrophoresis.

Journal: Analytical and bioanalytical chemistry 20030701

Title: Combined action of vasoactive amines and bradykinin mediates allergen-evoked thermal hyperalgesia in rats.

Journal: European journal of pharmacology 20030221

Title: Delivery outcome after the use of meclozine in early pregnancy.

Journal: European journal of epidemiology 20030101

Title: Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays.

Journal: Physiological genomics 20021029

Title: Spectrophotometric determination of meclozine HCl and papaverine HCl in their pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20020415

Title: Comparison of impact of the different hydrophilic carriers on the properties of piperazine-containing drug.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20010501

Title: The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception.

Journal: Neuroscience 20010101

Title: Inhibition of mediator release in RBL-2H3 cells by some H1-antagonist derived anti-allergic drugs: relation to lipophilicity and membrane effects.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 19950201

Title: Development of urinary retention during treatment with clozapine and meclizine.

Journal: The American journal of psychiatry 19940401

Title: Central nervous system effects of meclizine and dimenhydrinate: evidence of acute tolerance to antihistamines.

Journal: Journal of clinical pharmacology 19921101

Title: Memory loss, confusion, and disorientation in an elderly woman taking meclizine.

Journal: Journal of the American Geriatrics Society 19870501

Title: Drug-induced extrapyramidal signs in chronic liver disease--a case report.

Journal: Clinical toxicology 19770101

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