3251-69-2,MFCD00012698
Catalog No.:AA00BY6A

3251-69-2 | 4-Imidazoleacetic acid HCl

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Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$29.00   $20.00
- +
5g
97%
in stock  
$64.00   $45.00
- +
10g
97%
in stock  
$121.00   $85.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BY6A
Chemical Name:
4-Imidazoleacetic acid HCl
CAS Number:
3251-69-2
Molecular Formula:
C5H7ClN2O2
Molecular Weight:
162.5743
MDL Number:
MFCD00012698
SMILES:
OC(=O)Cc1cnc[nH]1.Cl
Properties
Properties
 
Form:
Solid  
MP:
218-222 °C(lit.)  
Solubility:
water: soluble100mg/mL, clear, faintly yellow  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
116  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
2  

Upstream Synthesis Route

[1]ChemMedChem,2016,vol.11,#20,p.2299-2310

[1]Patent:WO2016/109361,2016,A2,

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistry,1997,vol.5,p.1989-1998

[2]JournaloftheChemicalSociety.PerkintransactionsI,1980,vol.1,p.43-51

[3]Patent:US2003/232790,2003,A1.Locationinpatent:Page17

[4]ChemMedChem,2016,vol.11,p.2299-2310

[1]JournalofOrganicChemistry,1990,vol.55,p.5125-5132

[2]Patent:JP2015/93831,2015,A.Locationinpatent:Paragraph0016;0076;0078

[3]Patent:JP2015/93832,2015,A.Locationinpatent:Paragraph0077;0079

3251-69-2   
1'-2-(3H-imidazol-4-yl)-ethyl-3,3"-dimethyl-1',2',3',4',5',6'-hexahydro-2,2';6',2"terpyridine(HBrSalt) 
  4200-46-8 

[1]Patent:US2005/154201,2005,A1

943735-66-8    3251-69-2   
N-({5-(dimethylamino)methyl-2-(2-naphthyl)-1,3-thiazol-4-yl}methyl)-2-(1H-imidazol-4-yl)acetamide 

[1]Heterocycles,2007,vol.72,p.293-326

35661-60-0    35661-39-3    3251-69-2    22483-09-6    76-05-1   
(4-imidazolylacetyl)-EELLKKLEELLKKAG-Htetra(trifluoroacetate) 

[1]OrganicandBiomolecularChemistry,2007,vol.5,p.2225-2233

Literature

Title: Nanosegregated composites of an imidazolium salt and a layered inorganic compound: organization of both anions and cations in interlayer space.

Journal: Nanoscale 20101101

Title: A single step purification for autolytic zinc proteinases.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: Expression and purification of full-length recombinant PrP of high purity.

Journal: Methods in molecular biology (Clifton, N.J.) 20080101

Title: Highly Efficient Phosphopeptide Enrichment by Calcium Phosphate Precipitation Combined with Subsequent IMAC Enrichment.

Journal: Molecular & cellular proteomics : MCP 20071101

Title: 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.

Journal: Journal of medicinal chemistry 20070823

Title: Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.

Journal: The Journal of physiology 20070615

Title: Optimizing TiO2-based phosphopeptide enrichment for automated multidimensional liquid chromatography coupled to tandem mass spectrometry.

Journal: Analytical chemistry 20070615

Title: Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer.

Journal: Journal of proteome research 20070601

Title: Hair analysis of histamine and several metabolites in C3H/HeNCrj mice by ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry (UPLC-ESI-TOF-MS): influence of hair cycle and age.

Journal: Clinica chimica acta; international journal of clinical chemistry 20070301

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

Journal: Molecular & cellular proteomics : MCP 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Enhanced phosphopeptide isolation by Fe(III)-IMAC using 1,1,1,3,3,3-hexafluoroisopropanol.

Journal: Proteomics 20051101

Title: Kinetic analysis of the role of histidine chloramines in hypochlorous acid mediated protein oxidation.

Journal: Biochemistry 20050517

Title: Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.

Journal: The Journal of biological chemistry 20041224

Title: Peripheral GABAB agonists stimulate gastric acid secretion in mice.

Journal: British journal of pharmacology 20040701

Title: Coordination sphere vibrations in copper(II), nickel(II) and cobalt(II) complexes with 4-imidazoleacetic acid; metal isotope, deuteration, and density functional study.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040601

Title: Theoretical studies of IMAC interfacial phenomena for the production of protein C.

Journal: Advances in experimental medicine and biology 20030101

Title: Towards crystallization of hydrophobic myelin glycoproteins: P0 and PASII/PMP22.

Journal: Protein expression and purification 20021201

Title: Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening.

Journal: The Journal of biological chemistry 20021115

Title: A novel affinity gene fusion system allowing protein A-based recovery of non-immunoglobulin gene products.

Journal: Journal of biotechnology 20021009

Title: Medicinal chemistry and molecular pharmacology of GABA(C) receptors.

Journal: Current topics in medicinal chemistry 20020801

Title: Urinary histamine metabolite elevations during experimental influenza infection.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20011001

Title: Oxidative breakdown and conversion of urocanic acid isomers by hydroxyl radical generating systems.

Journal: Biochimica et biophysica acta 20010615

Title: Immunocytochemical and electrophysiological characterization of GABA receptors in the frog and turtle retina.

Journal: Vision research 20010301

Title: Studies on the possibility of histidine biosynthesis from histodinol, imidazolepyruvic acid, imidazoleacetica acid, and imidazolelactic acid by mixed ruminal bacteria, protozoa, and their mixture in vitro.

Journal: Applied microbiology and biotechnology 20010301

Title: Prell GD, et al. Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13677-82.

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SDS
Tags:3251-69-2 Molecular Formula|3251-69-2 MDL|3251-69-2 SMILES|3251-69-2 4-Imidazoleacetic acid HCl
Catalog No.: AA00BY6A
3251-69-2,MFCD00012698
3251-69-2 | 4-Imidazoleacetic acid HCl
Pack Size: 1g
Purity: 95%
in stock
$29.00 $20.00
Pack Size: 5g
Purity: 97%
in stock
$64.00 $45.00
Pack Size: 10g
Purity: 97%
in stock
$121.00 $85.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00BY6A
Chemical Name: 4-Imidazoleacetic acid HCl
CAS Number: 3251-69-2
Molecular Formula: C5H7ClN2O2
Molecular Weight: 162.5743
MDL Number: MFCD00012698
SMILES: OC(=O)Cc1cnc[nH]1.Cl
Properties
Form: Solid  
MP: 218-222 °C(lit.)  
Solubility: water: soluble100mg/mL, clear, faintly yellow  
Stability: Hygroscopic  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 116  
Covalently-Bonded Unit Count: 2  
Heavy Atom Count: 10  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 2  
Upstream Synthesis Route
18502-05-1    3251-69-2 

[1]ChemMedChem,2016,vol.11,#20,p.2299-2310

3251-69-2    928134-65-0    928134-66-1 

[1]Patent:WO2016/109361,2016,A2,

Downstream Synthesis Route
67-56-1    3251-69-2    4200-46-8 

[1]BioorganicandMedicinalChemistry,1997,vol.5,p.1989-1998

[2]JournaloftheChemicalSociety.PerkintransactionsI,1980,vol.1,p.43-51

[3]Patent:US2003/232790,2003,A1.Locationinpatent:Page17

[4]ChemMedChem,2016,vol.11,p.2299-2310

64-17-5    3251-69-2    28782-45-8 

[1]JournalofOrganicChemistry,1990,vol.55,p.5125-5132

[2]Patent:JP2015/93831,2015,A.Locationinpatent:Paragraph0016;0076;0078

[3]Patent:JP2015/93832,2015,A.Locationinpatent:Paragraph0077;0079

3251-69-2   
1'-2-(3H-imidazol-4-yl)-ethyl-3,3"-dimethyl-1',2',3',4',5',6'-hexahydro-2,2';6',2"terpyridine(HBrSalt) 
  4200-46-8 

[1]Patent:US2005/154201,2005,A1

943735-66-8    3251-69-2   
N-({5-(dimethylamino)methyl-2-(2-naphthyl)-1,3-thiazol-4-yl}methyl)-2-(1H-imidazol-4-yl)acetamide 

[1]Heterocycles,2007,vol.72,p.293-326

35661-60-0    35661-39-3    3251-69-2    22483-09-6    76-05-1   
(4-imidazolylacetyl)-EELLKKLEELLKKAG-Htetra(trifluoroacetate) 

[1]OrganicandBiomolecularChemistry,2007,vol.5,p.2225-2233

Literature fold

Title: Nanosegregated composites of an imidazolium salt and a layered inorganic compound: organization of both anions and cations in interlayer space.

Journal: Nanoscale20101101

Title: A single step purification for autolytic zinc proteinases.

Journal: Bioorganic & medicinal chemistry letters20100101

Title: Expression and purification of full-length recombinant PrP of high purity.

Journal: Methods in molecular biology (Clifton, N.J.)20080101

Title: Highly Efficient Phosphopeptide Enrichment by Calcium Phosphate Precipitation Combined with Subsequent IMAC Enrichment.

Journal: Molecular & cellular proteomics : MCP20071101

Title: 5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.

Journal: Journal of medicinal chemistry20070823

Title: Rat alpha6beta2delta GABAA receptors exhibit two distinct and separable agonist affinities.

Journal: The Journal of physiology20070615

Title: Optimizing TiO2-based phosphopeptide enrichment for automated multidimensional liquid chromatography coupled to tandem mass spectrometry.

Journal: Analytical chemistry20070615

Title: Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer.

Journal: Journal of proteome research20070601

Title: Hair analysis of histamine and several metabolites in C3H/HeNCrj mice by ultra performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry (UPLC-ESI-TOF-MS): influence of hair cycle and age.

Journal: Clinica chimica acta; international journal of clinical chemistry20070301

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

Journal: Molecular & cellular proteomics : MCP20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Enhanced phosphopeptide isolation by Fe(III)-IMAC using 1,1,1,3,3,3-hexafluoroisopropanol.

Journal: Proteomics20051101

Title: Kinetic analysis of the role of histidine chloramines in hypochlorous acid mediated protein oxidation.

Journal: Biochemistry20050517

Title: Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.

Journal: The Journal of biological chemistry20041224

Title: Peripheral GABAB agonists stimulate gastric acid secretion in mice.

Journal: British journal of pharmacology20040701

Title: Coordination sphere vibrations in copper(II), nickel(II) and cobalt(II) complexes with 4-imidazoleacetic acid; metal isotope, deuteration, and density functional study.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20040601

Title: Theoretical studies of IMAC interfacial phenomena for the production of protein C.

Journal: Advances in experimental medicine and biology20030101

Title: Towards crystallization of hydrophobic myelin glycoproteins: P0 and PASII/PMP22.

Journal: Protein expression and purification20021201

Title: Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening.

Journal: The Journal of biological chemistry20021115

Title: A novel affinity gene fusion system allowing protein A-based recovery of non-immunoglobulin gene products.

Journal: Journal of biotechnology20021009

Title: Medicinal chemistry and molecular pharmacology of GABA(C) receptors.

Journal: Current topics in medicinal chemistry20020801

Title: Urinary histamine metabolite elevations during experimental influenza infection.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology20011001

Title: Oxidative breakdown and conversion of urocanic acid isomers by hydroxyl radical generating systems.

Journal: Biochimica et biophysica acta20010615

Title: Immunocytochemical and electrophysiological characterization of GABA receptors in the frog and turtle retina.

Journal: Vision research20010301

Title: Studies on the possibility of histidine biosynthesis from histodinol, imidazolepyruvic acid, imidazoleacetica acid, and imidazolelactic acid by mixed ruminal bacteria, protozoa, and their mixture in vitro.

Journal: Applied microbiology and biotechnology20010301

Title: Prell GD, et al. Imidazoleacetic acid-ribotide: an endogenous ligand that stimulates imidazol(in)e receptors. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13677-82.

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