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928134-65-0,MFCD25976825
Catalog No.:AA00H1GZ

928134-65-0 | Lci699

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$125.00   $87.00
- +
10mg
≥98%
in stock  
$208.00   $145.00
- +
25mg
95%
in stock  
$366.00   $257.00
- +
50mg
≥98%
in stock  
$729.00   $510.00
- +
100mg
95%
in stock  
$1,112.00   $779.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00H1GZ
Chemical Name:
Lci699
CAS Number:
928134-65-0
Molecular Formula:
C13H10FN3
Molecular Weight:
227.2370
MDL Number:
MFCD25976825
SMILES:
N#Cc1ccc(c(c1)F)[C@H]1CCc2n1cnc2
Properties
Computed Properties
 
Complexity:
337  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
1.9  

Literature

Title: Therapy of endocrine disease: steroidogenesis enzyme inhibitors in Cushing's syndrome.

Journal: European journal of endocrinology 20150601

Title: Medical therapy for Cushing's disease: adrenal steroidogenesis inhibitors and glucocorticoid receptor blockers.

Journal: Pituitary 20150401

Title: Medical treatment of Cushing disease: new targets, new hope.

Journal: Endocrinology and metabolism clinics of North America 20150301

Title: Efficacy and safety of LCI699 for hypertension: a meta-analysis of randomized controlled trials and systematic review.

Journal: European review for medical and pharmacological sciences 20150101

Title: Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors.

Journal: Journal of medicinal chemistry 20140626

Title: The effects of aldosterone synthase inhibition on aldosterone and cortisol in patients with hypertension: a phase II, randomized, double-blind, placebo-controlled, multicenter study.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20120901

Title: Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial.

Journal: Circulation 20111101

Title: Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism.

Journal: Hypertension (Dallas, Tex. : 1979) 20101101

Title: Ménard J, et, al. Aldosterone synthase inhibition: cardiorenal protection in animal disease models and translation of hormonal effects to human subjects. J Transl Med. 2014 Dec 10;12:340.

Title: Creemers SG, et, al. Osilodrostat Is a Potential Novel Steroidogenesis Inhibitor for the Treatment of Cushing Syndrome: An In Vitro Study. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3437-3449.

Title: Li L, et, al. Osilodrostat (LCI699), a potent 11β-hydroxylase inhibitor, administered in combination with the multireceptor-targeted somatostatin analog pasireotide: A 13-week study in rats. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):224-33.

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