Home Other Building Blocks 405554-55-4
405554-55-4,MFCD16038645
Catalog No.:AA00BYEI

405554-55-4 | Sb590885

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$52.00   $36.00
- +
5mg
98%
in stock  
$128.00   $89.00
- +
10mg
98%
in stock  
$217.00   $152.00
- +
50mg
98%
in stock  
$550.00   $385.00
- +
250mg
98
in stock  
$2,522.00   $1,765.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BYEI
Chemical Name:
Sb590885
CAS Number:
405554-55-4
Molecular Formula:
C27H27N5O2
Molecular Weight:
453.5356
MDL Number:
MFCD16038645
SMILES:
O/N=C\1/CCc2c1ccc(c2)c1nc([nH]c1c1ccncc1)c1ccc(cc1)OCCN(C)C
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
674  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4  

Literature

Title: King AJ, et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res, 2006, 66(23), 11100-11105.

Title: Takle AK, et al. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett, 2006, 16(2), 378-381.

Title: Smalley KS, et al. Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas. Mol Cancer Ther, 2008, 7(9), 2876-2883.

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SDS
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