Home Other Building Blocks 349438-38-6
349438-38-6,MFCD02055160
Catalog No.:AA00C6FT

349438-38-6 | Alda 1

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$6.00   $4.00
- +
5mg
98+%
in stock  
$8.00   $6.00
- +
10mg
98+%
in stock  
$11.00   $8.00
- +
50mg
98+%
in stock  
$26.00   $18.00
- +
100mg
98+%
in stock  
$44.00   $31.00
- +
1g
98%
in stock  
$386.00   $270.00
- +
5g
98%
in stock  
$1,491.00   $1,044.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00C6FT
Chemical Name:
Alda 1
CAS Number:
349438-38-6
Molecular Formula:
C15H11Cl2NO3
Molecular Weight:
324.1587
MDL Number:
MFCD02055160
SMILES:
O=C(c1c(Cl)cccc1Cl)NCc1ccc2c(c1)OCO2
Properties
Computed Properties
 
Complexity:
372  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
4  

Upstream Synthesis Route

[1]JournalofBiologicalChemistry,2010,vol.285,#2,p.943-952

Literature

Title: ULK1-regulated autophagy: A mechanism in cellular protection for ALDH2 against hyperglycemia.

Journal: Toxicology letters 20180201

Title: Pharmacological activation of aldehyde dehydrogenase 2 promotes osteoblast differentiation via bone morphogenetic protein-2 and induces bone anabolic effect.

Journal: Toxicology and applied pharmacology 20170201

Title: Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism.

Journal: Experimental neurology 20150101

Title: The thiocarbamate disulphide drug, disulfiram induces osteopenia in rats by inhibition of osteoblast function due to suppression of acetaldehyde dehydrogenase activity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140501

Title: Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice.

Journal: Radiation research 20120701

Title: AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol.

Journal: Free radical biology & medicine 20111101

Title: Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females.

Journal: Circulation research 20100611

Title: Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant.

Journal: Nature structural & molecular biology 20100201

Title: Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1.

Journal: The Journal of biological chemistry 20100108

Title: Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart.

Journal: Science (New York, N.Y.) 20080912

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Stachowicz A, et al. Proteomic Analysis of Mitochondria-Enriched Fraction Isolated from the Frontal Cortex and Hippocampus of Apolipoprotein E Knockout Mice Treated with Alda-1, an Activator of Mitochondrial Aldehyde Dehydrogenase (ALDH2). Int J Mol Sci.

Title: Stachowicz A, et al. The impact of mitochondrial aldehyde dehydrogenase (ALDH2) activation by Alda-1 on the behavioral and biochemical disturbances in animal model of depression. Brain Behav Immun. 2016 Jan;51:144-53.

Title: Ikeda T, et al. Effects of Alda-1, an Aldehyde Dehydrogenase-2 Agonist, on Hypoglycemic Neuronal Death. PLoS One. 2015 Jun 17;10(6):e0128844.

Title: Gomes KM, et al. Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: benefits of Alda-1. Int J Cardiol. 2015 Jan 20;179:129-138.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:349438-38-6 Molecular Formula|349438-38-6 MDL|349438-38-6 SMILES|349438-38-6 Alda 1