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52029-86-4,MFCD06411456
Catalog No.:AA00D9O2

52029-86-4 | 7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE

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1mg
≥95% (mixture of isomers)
in stock  
$53.00   $37.00
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5mg
≥95% (mixture of isomers)
in stock  
$155.00   $108.00
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10mg
≥95% (mixture of isomers)
in stock  
$279.00   $195.00
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25mg
≥95% (mixture of isomers)
in stock  
$505.00   $353.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00D9O2
Chemical Name:
7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
CAS Number:
52029-86-4
Molecular Formula:
C21H14N2O5
Molecular Weight:
374.3463
MDL Number:
MFCD06411456
SMILES:
OC(=O)c1ccc2c3c1cccc3c(=O)n1c2nc2c1cccc2.CC(=O)O
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
565  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
3.5  

Downstream Synthesis Route
Literature

Title: Akt activation by Ca(2+)/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells.

Journal: The Journal of biological chemistry 20170825

Title: Pleiotropic roles of Ca(+2)/calmodulin-dependent pathways in regulating cadmium-induced toxicity in human osteoblast-like cell lines.

Journal: Toxicology letters 20161017

Title: S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.

Journal: The Journal of nutritional biochemistry 20130801

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Saponins, especially platycodin D, from Platycodon grandiflorum modulate hepatic lipogenesis in high-fat diet-fed rats and high glucose-exposed HepG2 cells.

Journal: Toxicology and applied pharmacology 20130301

Title: Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes.

Journal: Journal of cellular and molecular medicine 20120901

Title: Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120613

Title: Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells.

Journal: The Journal of biological chemistry 20120210

Title: Natural vanadium-containing Jeju ground water stimulates glucose uptake through the activation of AMP-activated protein kinase in L6 myotubes.

Journal: Molecular and cellular biochemistry 20120101

Title: Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.

Journal: PloS one 20120101

Title: CaMKKβ is involved in AMP-activated protein kinase activation by baicalin in LKB1 deficient cell lines.

Journal: PloS one 20120101

Title: Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress.

Journal: Cellular signalling 20111201

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Nonsteroidal anti-inflammatory drug flufenamic acid is a potent activator of AMP-activated protein kinase.

Journal: The Journal of pharmacology and experimental therapeutics 20111001

Title: Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1.

Journal: Journal of neuro-oncology 20110801

Title: Identification of new inhibitors of protein kinase R guided by statistical modeling.

Journal: Bioorganic & medicinal chemistry letters 20110701

Title: Crystal structure of the Ca²⁺/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609.

Journal: The Journal of biological chemistry 20110624

Title: Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes.

Journal: Journal of cellular biochemistry 20110501

Title: Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20110401

Title: eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1.

Journal: Biochimica et biophysica acta 20110201

Title: Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation.

Journal: Cell metabolism 20100609

Title: AMP-activated protein kinase induces actin cytoskeleton reorganization in epithelial cells.

Journal: Biochemical and biophysical research communications 20100604

Title: Urotensin II-induced signaling involved in proliferation of vascular smooth muscle cells.

Journal: Vascular health and risk management 20100101

Title: CaMKK is an upstream signal of AMP-activated protein kinase in regulation of substrate metabolism in contracting skeletal muscle.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20091201

Title: ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase.

Journal: The Journal of biological chemistry 20091120

Title: Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin.

Journal: Cell host & microbe 20090917

Title: Arabidopsis protein kinases GRIK1 and GRIK2 specifically activate SnRK1 by phosphorylating its activation loop.

Journal: Plant physiology 20090601

Title: Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta.

Journal: The Journal of biological chemistry 20090529

Title: Low salt concentrations activate AMP-activated protein kinase in mouse macula densa cells.

Journal: American journal of physiology. Renal physiology 20090401

Title: Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201

Title: SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase.

Journal: The Journal of biological chemistry 20080718

Title: AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase.

Journal: The Journal of biological chemistry 20080704

Title: A cascade of Ca(2+)/calmodulin-dependent protein kinases regulates the differentiation and functional activation of murine neutrophils.

Journal: Experimental hematology 20080701

Title: Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.

Journal: The Journal of biological chemistry 20080606

Title: Hypothalamic CaMKK2 contributes to the regulation of energy balance.

Journal: Cell metabolism 20080501

Title: The role of calcium/calmodulin-dependent protein kinase cascade on MIP-1alpha gene expression of ATL cells.

Journal: Experimental hematology 20080401

Title: Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes.

Journal: American journal of physiology. Cell physiology 20071001

Title: Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction.

Journal: American journal of physiology. Endocrinology and metabolism 20070501

Title: AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.

Journal: Biochemical and biophysical research communications 20070323

Title: The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases.

Journal: The Journal of biological chemistry 20050812

Title: Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

Journal: Cell metabolism 20050701

Title: Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

Journal: Cell metabolism 20050701

Title: Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness.

Journal: Journal of neurochemistry 20050401

Title: Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050202

Title: Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20040414

Title: Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells.

Journal: FEBS letters 20030828

Title: STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase.

Journal: The Journal of biological chemistry 20020503

Title: Thyroid hormone activates adenosine 5'-monophosphate-activated protein kinase via intracellular calcium mobilization and activation of calcium/calmodulin-dependent protein kinase kinase-beta.

Journal: Molecular endocrinology (Baltimore, Md.)

Title: Tokumitsu H, et al. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8.

Title: Kukimoto-Niino M, et al. Crystal structure of the Ca2+/calmodulin-dependent protein kinase kinase in complex with the inhibitor STO-609. J Biol Chem. 2011 Jun 24;286(25):22570-9.

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Tags:52029-86-4 Molecular Formula|52029-86-4 MDL|52029-86-4 SMILES|52029-86-4 7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE