Home Other Building Blocks 475488-23-4
475488-23-4,MFCD16038913
Catalog No.:AA00DB4B

475488-23-4 | Nvp-adw742

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$52.00   $36.00
- +
5mg
≥98%
in stock  
$150.00   $105.00
- +
10mg
≥98%
in stock  
$269.00   $188.00
- +
50mg
>98% (or refer to the Certificate of Analysis)
in stock  
$1,129.00   $790.00
- +
100mg
>98% (or refer to the Certificate of Analysis)
in stock  
$1,933.00   $1,353.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DB4B
Chemical Name:
Nvp-adw742
CAS Number:
475488-23-4
Molecular Formula:
C28H31N5O
Molecular Weight:
453.5786
MDL Number:
MFCD16038913
SMILES:
Nc1ncnc2c1c(cn2C1CC(C1)CN1CCCC1)c1cccc(c1)OCc1ccccc1
Properties
Computed Properties
 
Complexity:
645  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
4.6  

Literature

Title: The insulin-like growth factor-I receptor kinase inhibitor NVP-ADW742 sensitizes medulloblastoma to the effects of chemotherapy.

Journal: Oncology reports 20110601

Title: The insulin-like growth factor-1 receptor kinase inhibitor, NVP-ADW742, suppresses survival and resistance to chemotherapy in acute myeloid leukemia cells.

Journal: Oncology research 20100101

Title: [Progress in the studies on small molecule IGF-1R inhibitors].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20081001

Title: Pyrazolo[3,4-d]pyrimidines as potent inhibitors of the insulin-like growth factor receptor (IGF-IR).

Journal: Bioorganic & medicinal chemistry letters 20071001

Title: Insulin-like growth factor I receptor pathway inhibition by ADW742, alone or in combination with imatinib, doxorubicin, or vincristine, is a novel therapeutic approach in Ewing tumor.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060601

Title: Medicinal chemistry approaches to target the kinase activity of IGF-1R.

Journal: IDrugs : the investigational drugs journal 20060601

Title: The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050215

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SDS
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