434938-41-7
Catalog No.:AA00D9O5

434938-41-7 | K 41498

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≥98%
2 weeks  
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5mg
≥98%
2 weeks  
$472.00   $330.00
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10mg
≥98%
2 weeks  
$734.00   $514.00
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25mg
≥98%
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50mg
≥98%
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00D9O5
Chemical Name:
K 41498
CAS Number:
434938-41-7
Molecular Formula:
C162H276N48O46
Molecular Weight:
3632.2188
SMILES:
NCCCCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(CC)C)C(=O)N)C(O)C)CC(=O)O)CC(C)C)CC(C)C)CC(C)C)CCCNC(=N)N)CC(=O)N)CC(=O)N)C)C)CCC(=O)N)CCC(=O)N)CCCCN)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(CC)C)NC(=O)C(NC(=O)C(C(CC)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(Cc1ccccc1)N)Cc1nc[nH]c1)CC(C)C)CC(C)C)CCCNC(=N)N)CCCCN)CCCC)CCC(=O)O)CCC(=O)O)CCCCN)CCC(=O)N)CCC(=O)O
Properties
Computed Properties
 
Complexity:
8430  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
34  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
256  
Hydrogen Bond Acceptor Count:
54  
Hydrogen Bond Donor Count:
53  
Isotope Atom Count:
0  
Rotatable Bond Count:
136  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-19.4  

Literature

Title: Effects of corticotropin-releasing factor 1 receptor antagonism on the hypothalamic-pituitary-adrenal axis of rodents.

Journal: The Journal of pharmacology and experimental therapeutics 20120601

Title: Effects of corticotropin-releasing hormone receptor antagonists on the ethanol-induced increase of dynorphin A1-8 release in the rat central amygdala.

Journal: Alcohol (Fayetteville, N.Y.) 20111101

Title: Previous ethanol experience enhances synaptic plasticity of NMDA receptors in the ventral tegmental area.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110406

Title: Exploring the binding site crevice of a family B G protein-coupled receptor, the type 1 corticotropin releasing factor receptor.

Journal: Molecular pharmacology 20101001

Title: Corticotropin-releasing factor receptors induce calcium mobilization through cross-talk with Gq-coupled receptors.

Journal: European journal of pharmacology 20100910

Title: Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy.

Journal: Molecular pharmacology 20091201

Title: Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.

Journal: American journal of physiology. Heart and circulatory physiology 20090601

Title: Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide binding.

Journal: Molecular pharmacology 20090401

Title: Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions.

Journal: Neuroscience 20090317

Title: Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing factor receptor 1 (CRFR1).

Journal: The Journal of biological chemistry 20081219

Title: Corticotropin-releasing factor modulates maternal separation-induced ultrasonic vocalization in rat pups via activation of CRF1 receptor.

Journal: Brain research 20081009

Title: Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation.

Journal: Molecular pharmacology 20080501

Title: Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain.

Journal: British journal of pharmacology 20070701

Title: 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070307

Title: Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20070201

Title: Evidence that corticotropin-releasing factor receptor type 1 couples to Gs- and Gi-proteins through different conformations of its J-domain.

Journal: British journal of pharmacology 20061201

Title: A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060601

Title: Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats.

Journal: Peptides 20050701

Title: Sauvagine analogs selective for corticotropin releasing factor 2 receptor: effect of substitutions at positions 35 and 39 on CRF2R selectivity.

Journal: Peptides 20050501

Title: Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor.

Journal: European journal of pharmacology 20050221

Title: Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy.

Journal: Journal of medicinal chemistry 20050113

Title: Ethanol versus lipopolysaccharide-induced hypothermia: involvement of urocortin.

Journal: Neuroscience 20050101

Title: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of beta-arrestin 1 recruitment.

Journal: European journal of biochemistry 20041101

Title: Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells.

Journal: The Journal of biological chemistry 20040910

Title: Binding differences of human and amphibian corticotropin-releasing factor type 1 (CRF(1)) receptors: identification of amino acids mediating high-affinity astressin binding and functional antagonism.

Journal: Regulatory peptides 20040515

Title: Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists.

Journal: Biochemistry 20040406

Title: Conformational states of the corticotropin releasing factor 1 (CRF1) receptor: detection, and pharmacological evaluation by peptide ligands.

Journal: Peptides 20031201

Title: Corticotropin-releasing factor (CRF) and related peptides confer neuroprotection via type 1 CRF receptors.

Journal: Neuropharmacology 20031001

Title: A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats.

Journal: Brain research 20030919

Title: A soluble form of the first extracellular domain of mouse type 2beta corticotropin-releasing factor receptor reveals differential ligand specificity.

Journal: The Journal of biological chemistry 20030502

Title: Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists.

Journal: Molecular pharmacology 20030301

Title: Development of a selective photoactivatable antagonist for corticotropin-releasing factor receptor, type 2 (CRF2).

Journal: European journal of biochemistry 20021101

Title: An artificial peptide with corticotropin-releasing factor receptor-2 (CRF-R2) selective properties: the role of primary structure in the induction of signal transduction pathways.

Journal: The journal of peptide research : official journal of the American Peptide Society 20021001

Title: Sauvagine regulates Ca2+ oscillations and electrical membrane activity of melanotrope cells of Xenopus laevis.

Journal: Journal of neuroendocrinology 20021001

Title: Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor.

Journal: The Journal of biological chemistry 20020906

Title: The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain.

Journal: British journal of pharmacology 20020701

Title: N-glycosylation of CRF receptor type 1 is important for its ligand-specific interaction.

Journal: American journal of physiology. Endocrinology and metabolism 20011101

Title: Persistent corticotropin-releasing factor(1) receptor desensitization and downregulation in the human neuroblastoma cell line IMR-32.

Journal: Brain research. Molecular brain research 20010815

Title: An oxidation resistant radioligand for corticotropin-releasing factor receptors.

Journal: Peptides 20010701

Title: Homogeneous cell-based fluorescence polarization assay for the direct detection of cAMP.

Journal: Journal of biomolecular screening 20010401

Title: Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei.

Journal: International journal of peptide and protein research 19810801

Title: A Rühmann, et al. Design, synthesis and pharmacological characterization of new highly selective CRF(2) antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides. 2002 Mar;23(3):453-60.

Title: A J Lawrence, et al. The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain. Br J Pharmacol

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SDS
Tags:434938-41-7 Molecular Formula|434938-41-7 MDL|434938-41-7 SMILES|434938-41-7 K 41498
Catalog No.: AA00D9O5
434938-41-7
434938-41-7 | K 41498
Pack Size: 1mg
Purity: ≥98%
2 weeks
$186.00 $130.00
Pack Size: 5mg
Purity: ≥98%
2 weeks
$472.00 $330.00
Pack Size: 10mg
Purity: ≥98%
2 weeks
$734.00 $514.00
Pack Size: 25mg
Purity: ≥98%
2 weeks
$1,543.00 $1,080.00
Pack Size: 50mg
Purity: ≥98%
2 weeks
$2,424.00 $1,697.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00D9O5
Chemical Name: K 41498
CAS Number: 434938-41-7
Molecular Formula: C162H276N48O46
Molecular Weight: 3632.2188
SMILES: NCCCCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(CC)C)C(=O)N)C(O)C)CC(=O)O)CC(C)C)CC(C)C)CC(C)C)CCCNC(=N)N)CC(=O)N)CC(=O)N)C)C)CCC(=O)N)CCC(=O)N)CCCCN)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(CC)C)NC(=O)C(NC(=O)C(C(CC)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(Cc1ccccc1)N)Cc1nc[nH]c1)CC(C)C)CC(C)C)CCCNC(=N)N)CCCCN)CCCC)CCC(=O)O)CCC(=O)O)CCCCN)CCC(=O)N)CCC(=O)O
Properties
Complexity: 8430  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 34  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 256  
Hydrogen Bond Acceptor Count: 54  
Hydrogen Bond Donor Count: 53  
Isotope Atom Count: 0  
Rotatable Bond Count: 136  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -19.4  
Literature fold

Title: Effects of corticotropin-releasing factor 1 receptor antagonism on the hypothalamic-pituitary-adrenal axis of rodents.

Journal: The Journal of pharmacology and experimental therapeutics20120601

Title: Effects of corticotropin-releasing hormone receptor antagonists on the ethanol-induced increase of dynorphin A1-8 release in the rat central amygdala.

Journal: Alcohol (Fayetteville, N.Y.)20111101

Title: Previous ethanol experience enhances synaptic plasticity of NMDA receptors in the ventral tegmental area.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110406

Title: Exploring the binding site crevice of a family B G protein-coupled receptor, the type 1 corticotropin releasing factor receptor.

Journal: Molecular pharmacology20101001

Title: Corticotropin-releasing factor receptors induce calcium mobilization through cross-talk with Gq-coupled receptors.

Journal: European journal of pharmacology20100910

Title: Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy.

Journal: Molecular pharmacology20091201

Title: Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors.

Journal: American journal of physiology. Heart and circulatory physiology20090601

Title: Alanine scanning mutagenesis of the second extracellular loop of type 1 corticotropin-releasing factor receptor revealed residues critical for peptide binding.

Journal: Molecular pharmacology20090401

Title: Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions.

Journal: Neuroscience20090317

Title: Residue 17 of sauvagine cross-links to the first transmembrane domain of corticotropin-releasing factor receptor 1 (CRFR1).

Journal: The Journal of biological chemistry20081219

Title: Corticotropin-releasing factor modulates maternal separation-induced ultrasonic vocalization in rat pups via activation of CRF1 receptor.

Journal: Brain research20081009

Title: Allosteric ligands for the corticotropin releasing factor type 1 receptor modulate conformational states involved in receptor activation.

Journal: Molecular pharmacology20080501

Title: Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain.

Journal: British journal of pharmacology20070701

Title: 3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20070307

Title: Corticotropin-releasing hormone skin signaling is receptor-mediated and is predominant in the sebaceous glands.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20070201

Title: Evidence that corticotropin-releasing factor receptor type 1 couples to Gs- and Gi-proteins through different conformations of its J-domain.

Journal: British journal of pharmacology20061201

Title: A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20060601

Title: Peripheral injection of sauvagine prevents repeated colorectal distension-induced visceral pain in female rats.

Journal: Peptides20050701

Title: Sauvagine analogs selective for corticotropin releasing factor 2 receptor: effect of substitutions at positions 35 and 39 on CRF2R selectivity.

Journal: Peptides20050501

Title: Stress and central Urocortin increase anxiety-like behavior in the social interaction test via the CRF1 receptor.

Journal: European journal of pharmacology20050221

Title: Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy.

Journal: Journal of medicinal chemistry20050113

Title: Ethanol versus lipopolysaccharide-induced hypothermia: involvement of urocortin.

Journal: Neuroscience20050101

Title: Internalization of the human CRF receptor 1 is independent of classical phosphorylation sites and of beta-arrestin 1 recruitment.

Journal: European journal of biochemistry20041101

Title: Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 in human embryonic kidney 293 cells.

Journal: The Journal of biological chemistry20040910

Title: Binding differences of human and amphibian corticotropin-releasing factor type 1 (CRF(1)) receptors: identification of amino acids mediating high-affinity astressin binding and functional antagonism.

Journal: Regulatory peptides20040515

Title: Ligand affinity for amino-terminal and juxtamembrane domains of the corticotropin releasing factor type I receptor: regulation by G-protein and nonpeptide antagonists.

Journal: Biochemistry20040406

Title: Conformational states of the corticotropin releasing factor 1 (CRF1) receptor: detection, and pharmacological evaluation by peptide ligands.

Journal: Peptides20031201

Title: Corticotropin-releasing factor (CRF) and related peptides confer neuroprotection via type 1 CRF receptors.

Journal: Neuropharmacology20031001

Title: A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats.

Journal: Brain research20030919

Title: A soluble form of the first extracellular domain of mouse type 2beta corticotropin-releasing factor receptor reveals differential ligand specificity.

Journal: The Journal of biological chemistry20030502

Title: Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists.

Journal: Molecular pharmacology20030301

Title: Development of a selective photoactivatable antagonist for corticotropin-releasing factor receptor, type 2 (CRF2).

Journal: European journal of biochemistry20021101

Title: An artificial peptide with corticotropin-releasing factor receptor-2 (CRF-R2) selective properties: the role of primary structure in the induction of signal transduction pathways.

Journal: The journal of peptide research : official journal of the American Peptide Society20021001

Title: Sauvagine regulates Ca2+ oscillations and electrical membrane activity of melanotrope cells of Xenopus laevis.

Journal: Journal of neuroendocrinology20021001

Title: Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor.

Journal: The Journal of biological chemistry20020906

Title: The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain.

Journal: British journal of pharmacology20020701

Title: N-glycosylation of CRF receptor type 1 is important for its ligand-specific interaction.

Journal: American journal of physiology. Endocrinology and metabolism20011101

Title: Persistent corticotropin-releasing factor(1) receptor desensitization and downregulation in the human neuroblastoma cell line IMR-32.

Journal: Brain research. Molecular brain research20010815

Title: An oxidation resistant radioligand for corticotropin-releasing factor receptors.

Journal: Peptides20010701

Title: Homogeneous cell-based fluorescence polarization assay for the direct detection of cAMP.

Journal: Journal of biomolecular screening20010401

Title: Amino acid composition and sequence analysis of sauvagine, a new active peptide from the skin of Phyllomedusa sauvagei.

Journal: International journal of peptide and protein research19810801

Title: A Rühmann, et al. Design, synthesis and pharmacological characterization of new highly selective CRF(2) antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides. 2002 Mar;23(3):453-60.

Title: A J Lawrence, et al. The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain. Br J Pharmacol

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