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204656-20-2,MFCD31689263
Catalog No.:AA003R7S

204656-20-2 | Liraglutide

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Purity
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5mg
98%
in stock  
$204.00   $143.00
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25mg
98%
in stock  
$505.00   $354.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA003R7S
Chemical Name:
Liraglutide
CAS Number:
204656-20-2
Molecular Formula:
C172H265N43O51
Molecular Weight:
3751.2020
MDL Number:
MFCD31689263
SMILES:
CCCCCCCCCCCCCCCC(=O)N[C@H](C(=O)O)CCC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)O)CCCNC(=N)N)CCCNC(=N)N)C(C)C)CC(C)C)Cc1c[nH]c2c1cccc2)C)[C@H](CC)C)Cc1ccccc1)CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1[nH]cnc1)N)C)CCC(=O)O)Cc1ccccc1)CO)CC(=O)O)CO)CO)Cc1ccc(cc1)O)CC(C)C)CCC(=O)O)CCC(=O)N)C)C
Properties
Properties
 
Form:
Solid  
MP:
>182°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
8760  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
31  
Heavy Atom Count:
266  
Hydrogen Bond Acceptor Count:
55  
Hydrogen Bond Donor Count:
54  
Rotatable Bond Count:
132  
XLogP3:
-3.4  

Literature

Title: Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents.

Journal: Toxicology and applied pharmacology 20170401

Title: Obesity: Liraglutide--another weapon in the war against obesity?

Journal: Nature reviews. Endocrinology 20151001

Title: Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.

Journal: Journal of medicinal chemistry 20150924

Title: The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

Journal: Neuromolecular medicine 20130301

Title: Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats.

Journal: Endocrinology 20130301

Title: On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice.

Journal: Toxicologic pathology 20130201

Title: Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice.

Journal: Regulatory peptides 20121110

Title: Human embryonic stem cell differentiation into insulin secreting β-cells for diabetes.

Journal: Cell biology international 20121101

Title: Treatment evaluation of liraglutide in type 2 diabetes.

Journal: Expert opinion on biological therapy 20121101

Title: Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus.

Journal: Diabetes, obesity & metabolism 20121001

Title: GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases.

Journal: Metabolism: clinical and experimental 20121001

Title: Harnessing the incretin system beyond glucose control: potential cardiovascular benefits of GLP-1 receptor agonists in type 2 diabetes.

Journal: Diabetes & metabolism 20121001

Title: Recent advances in incretin-based therapies.

Journal: Clinical endocrinology 20121001

Title: An update in incretin-based therapy: a focus on glucagon-like peptide-1 receptor agonists.

Journal: Diabetes technology & therapeutics 20121001

Title: Cost-utility analysis of liraglutide versus glimepiride as add-on to metformin in type 2 diabetes patients in China.

Journal: International journal of technology assessment in health care 20121001

Title: Recent advancements in drug treatment of obesity.

Journal: Clinical medicine (London, England) 20121001

Title: Pancreatitis during treatment with liraglutide.

Journal: JOP : Journal of the pancreas 20120910

Title: Addition of liraglutide in patients with Type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20120901

Title: Early intervention with liraglutide improves glucose tolerance without affecting islet microcirculation in young Goto-Kakizaki rats.

Journal: Regulatory peptides 20120820

Title: GLP-1 based therapies: differential effects on fasting and postprandial glucose.

Journal: Diabetes, obesity & metabolism 20120801

Title: GLP-1 agonists exenatide and liraglutide: a review about their safety and efficacy.

Journal: Current clinical pharmacology 20120801

Title: Effect of the once-daily human GLP-1 analogue liraglutide on appetite, energy intake, energy expenditure and gastric emptying in type 2 diabetes.

Journal: Diabetes research and clinical practice 20120801

Title: Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis.

Journal: Diabetes, obesity & metabolism 20120801

Title: The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis.

Journal: American journal of physiology. Endocrinology and metabolism 20120715

Title: An overview of the pharmacokinetics, efficacy and safety of liraglutide.

Journal: Diabetes research and clinical practice 20120701

Title: Effects of liraglutide on β-cell-specific glucokinase-deficient neonatal mice.

Journal: Endocrinology 20120701

Title: Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets.

Journal: Diabetes care 20120701

Title: A comparison of currently available GLP-1 receptor agonists for the treatment of type 2 diabetes.

Journal: Expert opinion on pharmacotherapy 20120701

Title: Exenatide for once-weekly administration.

Journal: Drug and therapeutics bulletin 20120701

Title: [Liraglutide: new results in the treatment of type 2 diabetes mellitus].

Journal: Drugs of today (Barcelona, Spain : 1998) 20120701

Title: Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analog, liraglutide.

Journal: International journal of obesity (2005) 20120601

Title: Liraglutide: short-lived effect on gastric emptying -- long lasting effects on body weight.

Journal: Diabetes, obesity & metabolism 20120601

Title: Combination therapy with liraglutide and sulfonylurea for a type 2 diabetic patient with high titer of anti-insulin antibodies produced by insulin therapy.

Journal: Diabetes research and clinical practice 20120601

Title: Current treatments and strategies for type 2 diabetes: can we do better with GLP-1 receptor agonists?

Journal: Annals of medicine 20120601

Title: Non-insulin injectable treatments (glucagon-like peptide-1 and its analogs) and cardiovascular disease.

Journal: Diabetes technology & therapeutics 20120601

Title: Bringing liraglutide to market: a CER case study.

Journal: Journal of managed care pharmacy : JMCP 20120601

Title: [Effect of liraglutide on interleukin-1β expression in the pancreatic islets of OLETF rats].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120601

Title: Hormone copycats.

Journal: Diabetes forecast 20120601

Title: Consumer group calls for antidiabetes drug to be withdrawn.

Journal: BMJ (Clinical research ed.) 20120508

Title: Insulin avoidance and treatment outcomes among patients with a professional driving licence starting glucagon-like peptide 1 (GLP-1) agonists in the Association of British Clinical Diabetologists (ABCD) nationwide exenatide and liraglutide audits.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20120501

Title: The human GLP-1 analog liraglutide and the pancreas: evidence for the absence of structural pancreatic changes in three species.

Journal: Diabetes 20120501

Title: The novel use of GLP-1 analogue and insulin combination in type 2 diabetes mellitus.

Journal: Recent patents on endocrine, metabolic & immune drug discovery 20120501

Title: GLP-1-based therapies and the exocrine pancreas: more light, or just more heat?

Journal: Diabetes 20120501

Title: GLP-1 receptor agonist effects on normal and neoplastic pancreata.

Journal: Diabetes 20120501

Title: Liraglutide treatment in a patient with HIV and uncontrolled insulin-treated type 2 diabetes.

Journal: Diabetes care 20120501

Title: The role of GLP-1 mimetics and basal insulin analogues in type 2 diabetes mellitus: guidance from studies of liraglutide.

Journal: Diabetes, obesity & metabolism 20120401

Title: The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide.

Journal: Neuropharmacology 20120401

Title: The glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation in endothelial cells.

Journal: Atherosclerosis 20120401

Title: Current challenges in type 2 diabetes.

Journal: Diabetes, obesity & metabolism 20120401

Title: The design of the liraglutide clinical trial programme.

Journal: Diabetes, obesity & metabolism 20120401

Title: Liraglutide in oral antidiabetic drug combination therapy.

Journal: Diabetes, obesity & metabolism 20120401

Title: Comparison of liraglutide versus other incretin-related anti-hyperglycaemic agents.

Journal: Diabetes, obesity & metabolism 20120401

Title: Liraglutide: from clinical trials to clinical practice.

Journal: Diabetes, obesity & metabolism 20120401

Title: Non-glycaemic effects mediated via GLP-1 receptor agonists and the potential for exploiting these for therapeutic benefit: focus on liraglutide.

Journal: Diabetes, obesity & metabolism 20120401

Title: GLP-1 receptor agonists: a clinical perspective on cardiovascular effects.

Journal: Diabetes & vascular disease research 20120401

Title: [The pharmacological treatment of obesity: past, present and future].

Journal: Orvosi hetilap 20120311

Title: Cost-utility analysis of liraglutide compared with sulphonylurea or sitagliptin, all as add-on to metformin monotherapy in Type 2 diabetes mellitus.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20120301

Title: GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation.

Journal: Endocrinology 20120301

Title: Liraglutide-associated acute pancreatitis.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120301

Title: Incretin-based therapies in clinical practice: from efficacy to effectiveness. Focus on liraglutide.

Journal: Minerva endocrinologica 20120301

Title: Regulation of adipocyte formation by GLP-1/GLP-1R signaling.

Journal: The Journal of biological chemistry 20120224

Title: GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress.

Journal: Regulatory peptides 20120210

Title: Effects of liraglutide and sibutramine on food intake, palatability, body weight and glucose tolerance in the gubra DIO-rats.

Journal: Acta pharmacologica Sinica 20120201

Title: Glucagon-like peptide-1 agonists.

Journal: BMJ (Clinical research ed.) 20120110

Title: Clinical use of liraglutide in type 2 diabetes and its effects on cardiovascular risk factors.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Title: Achieving a clinically relevant composite outcome of an HbA1c of <7% without weight gain or hypoglycaemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial programme.

Journal: Diabetes, obesity & metabolism 20120101

Title: The Akt/FoxO1/p27 pathway mediates the proliferative action of liraglutide in β cells.

Journal: Molecular medicine reports 20120101

Title: Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20120101

Title: [The new antidiabetic agents in the firing line.... safety reasons or witch hunt?].

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20120101

Title: Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials.

Journal: BMJ (Clinical research ed.) 20120101

Title: Liraglutide-induced acute kidney injury.

Journal: Pharmacotherapy 20120101

Title: Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis.

Journal: BMC neuroscience 20120101

Title: Exenatide BID and liraglutide QD treatment patterns among type 2 diabetes patients in Germany.

Journal: Journal of medical economics 20120101

Title: Hypoglycemics for the treatment of type 2 diabetes in patients with chronic kidney disease: a focus on new agents.

Journal: CANNT journal = Journal ACITN 20120101

Title: Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor.

Journal: Experimental diabetes research 20120101

Title: Effects of glucagon-like peptide-1 receptor agonists on body weight: a meta-analysis.

Journal: Experimental diabetes research 20120101

Title: A review on the association between glucagon-like peptide-1 receptor agonists and thyroid cancer.

Journal: Experimental diabetes research 20120101

Title: Vesiculopustular dermatosis: an uncommon side-effect of liraglutide?

Journal: Journal of diabetes and its complications 20120101

Title: The glucagon-like peptide-1 analog liraglutide suppresses ghrelin and controls diabetes in a patient with Prader-Willi syndrome.

Journal: Endocrine journal 20120101

Title: Long-term clinical and economic outcomes associated with liraglutide versus sitagliptin therapy when added to metformin in the treatment of type 2 diabetes: a CORE Diabetes Model analysis.

Journal: Journal of medical economics 20120101

Title: Willingness to pay for diabetes drug therapy in type 2 diabetes patients: based on LEAD clinical programme results.

Journal: Journal of medical economics 20120101

Title: The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone.

Journal: TheScientificWorldJournal 20120101

Title: Efficacy of liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, on body weight, eating behavior, and glycemic control, in Japanese obese type 2 diabetes.

Journal: Cardiovascular diabetology 20120101

Title: Pancreatitis with pancreatic tail swelling associated with incretin-based therapies detected radiologically in two cases of diabetic patients with end-stage renal disease.

Journal: Internal medicine (Tokyo, Japan) 20120101

Title: Liraglutide: a review of its use in the management of type 2 diabetes mellitus.

Journal: Drugs 20111203

Title: Treatment with liraglutide--a once-daily GLP-1 analog--does not reduce the bioavailability of ethinyl estradiol/levonorgestrel taken as an oral combination contraceptive drug.

Journal: Journal of clinical pharmacology 20111201

Title: The pharmacokinetics, pharmacodynamics, and tolerability of liraglutide, a once-daily human GLP-1 analogue, after multiple subcutaneous administration in healthy Chinese male subjects.

Journal: Journal of clinical pharmacology 20111201

Title: Beyond glucose lowering: glucagon-like peptide-1 receptor agonists, body weight and the cardiovascular system.

Journal: Diabetes & metabolism 20111201

Title: Emerging GLP-1 receptor agonists.

Journal: Expert opinion on emerging drugs 20111201

Title: Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20111201

Title: Comparison of the efficacy and tolerability profile of liraglutide, a once-daily human GLP-1 analog, in patients with type 2 diabetes ≥65 and <65 years of age: a pooled analysis from phase III studies.

Journal: The American journal of geriatric pharmacotherapy 20111201

Title: [Protective effects of glucagon-like peptide-1 on beta-cells: preclinical and clinical data].

Journal: Giornale italiano di cardiologia (2006) 20111201

Title: [Effects of glucagon-like peptide-1 on appetite and body weight: preclinical and clinical data].

Journal: Giornale italiano di cardiologia (2006) 20111201

Title: Efficacy and tolerability of liraglutide in combination with other antidiabetic drugs in type 2 diabetes.

Journal: Acta bio-medica : Atenei Parmensis 20111201

Title: [Incretin-based therapy for treating patients with type 2 diabetes].

Journal: Orvosi hetilap 20111127

Title: Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.

Journal: Diabetologia 20111101

Title: Liraglutide narrows the range of circadian glycemic variations in Japanese type 2 diabetes patients and nearly flattens these variations in drug-naive type 2 diabetes patients: a continuous glucose monitoring-based study.

Journal: Diabetes technology & therapeutics 20111101

Title: Evaluating the long-term cost-effectiveness of liraglutide versus exenatide BID in patients with type 2 diabetes who fail to improve with oral antidiabetic agents.

Journal: Clinical therapeutics 20111101

Title: The pharmacologic basis for clinical differences among GLP-1 receptor agonists and DPP-4 inhibitors.

Journal: Postgraduate medicine 20111101

Title: Accuracy of dosage volume for halfway doses in the Victoza Pen.

Journal: Journal of diabetes science and technology 20111101

Title: An analysis of dosage volume for halfway doses in the Victoza Pen.

Journal: Journal of diabetes science and technology 20111101

Title: The efficacy and safety of liraglutide.

Journal: International journal of clinical pharmacy 20111001

Title: Glucagon-like peptide-1 analogues for Type 2 diabetes mellitus: current and emerging agents.

Journal: Drugs 20110910

Title: The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review.

Journal: Diabetes/metabolism research and reviews 20110901

Title: Peptide complex containing GLP-1 exhibited long-acting properties in the treatment of type 2 diabetes.

Journal: Diabetes research and clinical practice 20110901

Title: GLP-1 receptor agonists today.

Journal: Diabetes research and clinical practice 20110901

Title: Liraglutide: clinical pharmacology and considerations for therapy.

Journal: Pharmacotherapy 20110901

Title: Cardiovascular effects of glucagonlike peptide-1 agonists.

Journal: The American journal of cardiology 20110802

Title: Ongoing clinical trials evaluating the cardiovascular safety and efficacy of therapeutic approaches to diabetes mellitus.

Journal: The American journal of cardiology 20110802

Title: Administration of an acylated GLP-1 and GIP preparation provides added beneficial glucose-lowering and insulinotropic actions over single incretins in mice with Type 2 diabetes and obesity.

Journal: Clinical science (London, England : 1979) 20110801

Title: GLP-1 receptor agonists and HBA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials.

Journal: Current medical research and opinion 20110801

Title: Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4.

Journal: Endocrinology 20110801

Title: The effect of the once-daily human glucagon-like peptide 1 analog liraglutide on the pharmacokinetics of acetaminophen.

Journal: Advances in therapy 20110801

Title: Efficacy of liraglutide in a patient with type 2 diabetes and cryptogenic cirrhosis.

Journal: Acta bio-medica : Atenei Parmensis 20110801

Title: The contribution of serotonin 5-HT2C and melanocortin-4 receptors to the satiety signaling of glucagon-like peptide 1 and liraglutide, a glucagon-like peptide 1 receptor agonist, in mice.

Journal: Biochemical and biophysical research communications 20110729

Title: Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats.

Journal: Obesity (Silver Spring, Md.) 20110701

Title: Liraglutide for type 2 diabetes mellitus.

Journal: Expert opinion on biological therapy 20110701

Title: Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function.

Journal: Diabetes care 20110701

Title: Liraglutide as additional treatment for type 1 diabetes.

Journal: European journal of endocrinology 20110701

Title: Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase 2: 3 liraglutide clinical development studies.

Journal: Diabetes & vascular disease research 20110701

Title: Efficacy and safety of long-acting glucagon-like peptide-1 receptor agonists compared with exenatide twice daily and sitagliptin in type 2 diabetes mellitus: a systematic review and meta-analysis.

Journal: The Annals of pharmacotherapy 20110701

Title: Review of the therapeutic uses of liraglutide.

Journal: Clinical therapeutics 20110701

Title: [Weight reducing and glucose reducing effects of liraglutide treatment for patients with type 2 diabetes].

Journal: Ugeskrift for laeger 20110627

Title: Effect of three different injection sites on the pharmacokinetics of the once-daily human GLP-1 analogue liraglutide.

Journal: Journal of clinical pharmacology 20110601

Title: Patient-reported outcomes are superior in patients with Type 2 diabetes treated with liraglutide as compared with exenatide, when added to metformin, sulphonylurea or both: results from a randomized, open-label study.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20110601

Title: Liraglutide therapy in Prader-Willi syndrome.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20110601

Title: Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: results from the Liraglutide Effect and Action in Diabetes (LEAD) trials.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on plasma omentin-1 levels in patients with type 2 diabetes mellitus.

Journal: Diabetes research and clinical practice 20110601

Title: Liraglutide: once-daily GLP-1 agonist for the treatment of type 2 diabetes.

Journal: Journal of clinical pharmacy and therapeutics 20110601

Title: Place in therapy for liraglutide and saxagliptin for type 2 diabetes.

Journal: Southern medical journal 20110601

Title: Recent diabetes issues affecting the primary care clinician.

Journal: Southern medical journal 20110601

Title: An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future.

Journal: Diabetes, obesity & metabolism 20110501

Title: An analysis of the impact of FDA's guidelines for addressing cardiovascular risk of drugs for type 2 diabetes on clinical development.

Journal: Contemporary clinical trials 20110501

Title: The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes.

Journal: Diabetologia 20110501

Title: Cost-effectiveness of liraglutide versus rosiglitazone, both in combination with glimepiride in treatment of type 2 diabetes in the US.

Journal: Current medical research and opinion 20110501

Title: The effect of liraglutide added to U-500 insulin in patients with type 2 diabetes and high insulin requirements.

Journal: Diabetes technology & therapeutics 20110501

Title: Incretin effects on β-cell function, replication, and mass: the human perspective.

Journal: Diabetes care 20110501

Title: Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability.

Journal: Diabetes care 20110501

Title: [Successful treatment with liraglutide in type 1 diabetes and MODY].

Journal: Deutsche medizinische Wochenschrift (1946) 20110501

Title: [Incretin analogues as a novel treatment strategy for Alzheimer's disease].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501

Title: [Liraglutide].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501

Title: Liraglutide for the treatment of type 2 diabetes.

Journal: Health technology assessment (Winchester, England) 20110501

Title: The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110427

Title: Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes.

Journal: Diabetes, obesity & metabolism 20110401

Title: Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain.

Journal: Journal of neuroscience research 20110401

Title: One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial.

Journal: International journal of clinical practice 20110401

Title: Acute pancreatitis associated with liraglutide.

Journal: The Annals of pharmacotherapy 20110401

Title: A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-/- mouse model.

Journal: Diabetes & vascular disease research 20110401

Title: [Treatment of type 2 diabetes mellitus with GLP-1 agonists].

Journal: Vnitrni lekarstvi 20110401

Title: Liraglutide - overview of the preclinical and clinical data and its role in the treatment of type 2 diabetes.

Journal: Diabetes, obesity & metabolism 20110301

Title: GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide.

Journal: The Journal of clinical endocrinology and metabolism 20110301

Title: Liraglutide improves treatment satisfaction in people with Type 2 diabetes compared with sitagliptin, each as an add on to metformin.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20110301

Title: The once-daily human glucagon-like peptide-1 (GLP-1) analog liraglutide improves postprandial glucose levels in type 2 diabetes patients.

Journal: Advances in therapy 20110301

Title: Liraglutide: a review of the first once-daily GLP-1 receptor agonist.

Journal: The American journal of managed care 20110301

Title: Glucagon-like peptide-1 analogues for type 2 diabetes.

Journal: BMJ (Clinical research ed.) 20110216

Title: Optimizing outcomes for GLP-1 agonists.

Journal: The Journal of the American Osteopathic Association 20110201

Title: Incretin therapies in the management of elderly patients with type 2 diabetes mellitus.

Journal: Hospital practice (1995) 20110201

Title: Co-administration of liraglutide with insulin detemir demonstrates additive pharmacodynamic effects with no pharmacokinetic interaction.

Journal: Diabetes, obesity & metabolism 20110101

Title: Liraglutide provides similar glycaemic control as glimepiride (both in combination with metformin) and reduces body weight and systolic blood pressure in Asian population with type 2 diabetes from China, South Korea and India: a 16-week, randomized, double-blind, active control trial(*).

Journal: Diabetes, obesity & metabolism 20110101

Title: Focus on incretin-based therapies: targeting the core defects of type 2 diabetes.

Journal: Postgraduate medicine 20110101

Title: Glucagon-like peptide-1 receptor agonists and cardiovascular events: a meta-analysis of randomized clinical trials.

Journal: Experimental diabetes research 20110101

Title: Mild renal impairment and the efficacy and safety of liraglutide.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Title: [Effects of glucagon-like peptide 1 and its receptor agonist - liraglutide on cardiovascular system].

Journal: Kardiologia polska 20110101

Title: Liraglutide prevents hypoadiponectinemia-induced insulin resistance and alterations of gene expression involved in glucose and lipid metabolism.

Journal: Molecular medicine (Cambridge, Mass.) 20110101

Title: Short-term effects of liraglutide on visceral fat adiposity, appetite, and food preference: a pilot study of obese Japanese patients with type 2 diabetes.

Journal: Cardiovascular diabetology 20110101

Title: [Liraglutide in the treatment of diabetes type 2].

Journal: Lijecnicki vjesnik 20110101

Title: Efficacy of antihyperglycemic therapies and the influence of baseline hemoglobin A(1C): a meta-analysis of the liraglutide development program.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Title: Activation of G-protein-coupled receptors and thyroid malignant tumors: the jury is still out.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Title: Liraglutide and calcitonin.

Journal: Journal of diabetes 20101201

Title: Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide.

Journal: British journal of clinical pharmacology 20101201

Title: [Glucagon-like peptide-1 analogues: effects on body weight and glycemia].

Journal: Giornale italiano di cardiologia (2006) 20101201

Title: Metabolism and excretion of the once-daily human glucagon-like peptide-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101101

Title: [Cardiac effects of glucagon-like peptide 1].

Journal: Ugeskrift for laeger 20101011

Title: [Glucagon-like peptide-1: a cardiological perspective].

Journal: Ugeskrift for laeger 20101011

Title: [New data from the US-American Diabetes Congress. GLP-1 effect: more than reducing blood glucose].

Journal: MMW Fortschritte der Medizin 20101007

Title: The future use of liraglutide: implications of the LEAD-2 study for treatment guidelines in type 2 diabetes.

Journal: Primary care diabetes 20101001

Title: A glucagon-like peptide-1 (GLP-1) analogue, liraglutide, upregulates nitric oxide production and exerts anti-inflammatory action in endothelial cells.

Journal: Diabetologia 20101001

Title: Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats.

Journal: Diabetes 20101001

Title: Liraglutide: the therapeutic promise from animal models.

Journal: International journal of clinical practice. Supplement 20101001

Title: Early clinical studies with liraglutide.

Journal: International journal of clinical practice. Supplement 20101001

Title: Glycaemic control with liraglutide: the phase 3 trial programme.

Journal: International journal of clinical practice. Supplement 20101001

Title: Liraglutide: effects beyond glycaemic control in diabetes treatment.

Journal: International journal of clinical practice. Supplement 20101001

Title: Clinical experience with liraglutide.

Journal: International journal of clinical practice. Supplement 20101001

Title: Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance.

Journal: Diabetes, obesity & metabolism 20101001

Title: [Pharmacological and clinical profiles of a human GLP-1 analogue, liraglutide (Victoza(®))].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20101001

Title: Liraglutide: can it make a difference in the treatment of type 2 diabetes?

Journal: International journal of clinical practice. Supplement 20101001

Title: Liraglutide in clinical practice: dosing, safety and efficacy.

Journal: International journal of clinical practice. Supplement 20101001

Title: The incretin system in the management of type 2 diabetes mellitus.

Journal: Clinical medicine (London, England) 20101001

Title: NICE approves liraglutide for diabetic patients not achieving glucose control.

Journal: BMJ (Clinical research ed.) 20100915

Title: Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome.

Journal: The Journal of endocrinology 20100901

Title: Distinguishing among incretin-based therapies. Glucose-lowering effects of incretin-based therapies.

Journal: The Journal of family practice 20100901

Title: Distinguishing among incretin-based therapies. Safety, tolerability, and nonglycemic effects of incretin-based therapies.

Journal: The Journal of family practice 20100901

Title: Distinguishing among incretin-based therapies. Patient education and self-management.

Journal: The Journal of family practice 20100901

Title: Distinguishing among incretin-based therapies. Introduction.

Journal: The Journal of family practice 20100901

Title: Distinguishing among incretin-based therapies. Pathophysiology of type 2 diabetes mellitus: potential role of incretin-based therapies.

Journal: The Journal of family practice 20100901

Title: Results of a model analysis of the cost-effectiveness of liraglutide versus exenatide added to metformin, glimepiride, or both for the treatment of type 2 diabetes in the United States.

Journal: Clinical therapeutics 20100901

Title: Liraglutide: a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes mellitus.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100815

Title: Population pharmacokinetics of liraglutide, a once-daily human glucagon-like peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide.

Journal: Journal of clinical pharmacology 20100801

Title: Effects of gamma-glutamyl linker on DPP-IV resistance, duration of action and biological efficacy of acylated glucagon-like peptide-1.

Journal: Biochemical pharmacology 20100801

Title: Managing type 2 diabetes in the primary care setting: beyond glucocentricity.

Journal: The American journal of the medical sciences 20100801

Title: [Therapy of obesity with liraglutide. NN8022-1807 study].

Journal: Der Internist 20100801

Title: Incretin-based therapies in the management of type 2 diabetes: rationale and reality in a managed care setting.

Journal: The American journal of managed care 20100801

Title: Patient-reported outcomes in patients with type 2 diabetes treated with liraglutide or glimepiride, both as add-on to metformin.

Journal: Primary care diabetes 20100701

Title: Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: results from a randomized controlled trial in patients with type 2 diabetes.

Journal: Diabetes, obesity & metabolism 20100701

Title: Incretin agents in type 2 diabetes.

Journal: Canadian family physician Medecin de famille canadien 20100701

Title: Incretin physiology and its role in type 2 diabetes mellitus.

Journal: The Journal of the American Osteopathic Association 20100701

Title: Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents.

Journal: Diabetes care 20100601

Title: Diabesity: therapeutic options.

Journal: Diabetes, obesity & metabolism 20100601

Title: Liraglutide. Type 2 diabetes: more prudent to continue using exenatide.

Journal: Prescrire international 20100601

Title: Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vs glibenclamide monotherapy in Japanese patients with type 2 diabetes.

Journal: Current medical research and opinion 20100501

Title: Liraglutide for type 2 diabetes?

Journal: Drug and therapeutics bulletin 20100501

Title: Choosing among the incretin agents and why it matters.

Journal: The Journal of family practice 20100501

Title: Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial.

Journal: Lancet (London, England) 20100424

Title: [New hypoglycemic agents in type 2 diabetes].

Journal: La Revue du praticien 20100420

Title: Liraglutide (Victoza) for type 2 diabetes.

Journal: The Medical letter on drugs and therapeutics 20100405

Title: Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation.

Journal: Endocrinology 20100401

Title: Liraglutide.

Journal: Nature reviews. Drug discovery 20100401

Title: Improved glycaemic control with minimal hypoglycaemia and no weight change with the once-daily human glucagon-like peptide-1 analogue liraglutide as add-on to sulphonylurea in Japanese patients with type 2 diabetes.

Journal: Diabetes, obesity & metabolism 20100401

Title: Once-weekly GLP-1 agonists: How do they differ from exenatide and liraglutide?

Journal: Current diabetes reports 20100401

Title: Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease.

Journal: European journal of pharmacology 20100325

Title: Weighing risks and benefits of liraglutide--the FDA's review of a new antidiabetic therapy.

Journal: The New England journal of medicine 20100304

Title: Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20100301

Title: Effects of incretin hormones on beta-cell mass and function, body weight, and hepatic and myocardial function.

Journal: The American journal of medicine 20100301

Title: Liraglutide in islet transplantation: from bench to bedside.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20100301

Title: Insulin-releasing and metabolic effects of small molecule GLP-1 receptor agonist 6,7-dichloro-2-methylsulfonyl-3-N-tert-butylaminoquinoxaline.

Journal: European journal of pharmacology 20100225

Title: Liraglutide, but not vildagliptin, restores normoglycaemia and insulin content in the animal model of type 2 diabetes, Psammomys obesus.

Journal: Regulatory peptides 20100225

Title: Liraglutide for weight loss in obese people.

Journal: Lancet (London, England) 20100213

Title: Liraglutide for weight loss in obese people.

Journal: Lancet (London, England) 20100213

Title: Incretin concepts.

Journal: Diabetes care 20100201

Title: [Beta-cell function in the foreground. GLP-1 based therapy of type 2 diabetes].

Journal: MMW Fortschritte der Medizin 20100114

Title: Adding liraglutide to oral antidiabetic drug therapy: onset of treatment effects over time.

Journal: International journal of clinical practice 20100101

Title: Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management.

Journal: Postgraduate medicine 20100101

Title: Therapeutic options that provide glycemic control and weight loss for patients with type 2 diabetes.

Journal: Postgraduate medicine 20100101

Title: Clinical approaches to preserve beta-cell function in diabetes.

Journal: Advances in experimental medicine and biology 20100101

Title: [New blood glucose-lowering drugs in type 2 diabetes: a review of the literature].

Journal: Nederlands tijdschrift voor geneeskunde 20100101

Title: Is liraglutide a useful addition to diabetes therapy?

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

Title: New drugs: Liraglutide, dalfampridine, and abobotulinumtoxinA.

Journal: Journal of the American Pharmacists Association : JAPhA 20100101

Title: A meta-analysis of placebo-controlled clinical trials assessing the efficacy and safety of incretin-based medications in patients with type 2 diabetes.

Journal: Pharmacology 20100101

Title: [Liraglutide (Victoza): human glucagon-like peptide-1 used in once daily injection for the treatment of type 2 diabetes].

Journal: Revue medicale de Liege 20100101

Title: A comparison of preferences for two GLP-1 products--liraglutide and exenatide--for the treatment of type 2 diabetes.

Journal: Journal of medical economics 20100101

Title: Liraglutide in the management of type 2 diabetes.

Journal: Drug design, development and therapy 20100101

Title: [Liraglutide and glimepiride on glycaemic control in type 2 diabetes in the Mexican cohort (LEAD 3)].

Journal: Revista medica del Instituto Mexicano del Seguro Social 20100101

Title: The effects of glucagon-like peptide-1 on the beta cell.

Journal: Diabetes, obesity & metabolism 20091201

Title: The safety and efficacy of liraglutide with or without oral antidiabetic drug therapy in type 2 diabetes: an overview of the LEAD 1-5 studies.

Journal: Diabetes, obesity & metabolism 20091201

Title: Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue.

Journal: Diabetes, obesity & metabolism 20091201

Title: Differentiating incretin therapies based on structure, activity, and metabolism: focus on liraglutide.

Journal: Pharmacotherapy 20091201

Title: Pharmacokinetics and pharmacodynamics of liraglutide, a long-acting, potent glucagon-like peptide-1 analog.

Journal: Pharmacotherapy 20091201

Title: Clinical studies of liraglutide, a novel, once-daily human glucagon-like peptide-1 analog for improved management of type 2 diabetes mellitus.

Journal: Pharmacotherapy 20091201

Title: Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide.

Journal: British journal of clinical pharmacology 20091201

Title: Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study.

Journal: Lancet (London, England) 20091107

Title: Gastrointestinal hormones and weight management.

Journal: Lancet (London, England) 20091107

Title: Absence of QTc prolongation in a thorough QT study with subcutaneous liraglutide, a once-daily human GLP-1 analog for treatment of type 2 diabetes.

Journal: Journal of clinical pharmacology 20091101

Title: A simulation of the comparative long-term effectiveness of liraglutide and glimepiride monotherapies in patients with type 2 diabetes mellitus.

Journal: Pharmacotherapy 20091101

Title: [Liraglutide: a human GLP-1 analogue for the treatment of diabetes mellitus type 2].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20091101

Title: A review of efficacy and safety data regarding the use of liraglutide, a once-daily human glucagon-like peptide 1 analogue, in the treatment of type 2 diabetes mellitus.

Journal: Clinical therapeutics 20091101

Title: Novel therapeutics for type 2 diabetes: incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors.

Journal: Pharmacology & therapeutics 20091001

Title: Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial.

Journal: Diabetologia 20091001

Title: Liraglutide: a review of its use in type 2 diabetes mellitus.

Journal: Drugs 20091001

Title: Glucagon-like peptide-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice.

Journal: Diabetes 20090901

Title: Liraglutide: a once-daily incretin mimetic for the treatment of type 2 diabetes mellitus.

Journal: The Annals of pharmacotherapy 20090901

Title: Beyond glycemic control: treating the entire type 2 diabetes disorder.

Journal: Postgraduate medicine 20090901

Title: Liraglutide: a once-daily human glucagon-like peptide-1 analogue.

Journal: Journal of endocrinological investigation 20090901

Title: Synergistic effect of the human GLP-1 analogue liraglutide and a dual PPARalpha/gamma agonist on glycaemic control in Zucker diabetic fatty rats.

Journal: Diabetes, obesity & metabolism 20090801

Title: Treatment of type 2 diabetes with glucagon-like peptide-1 receptor agonists.

Journal: International journal of clinical practice 20090801

Title: Exenatide and liraglutide: different approaches to develop GLP-1 receptor agonists (incretin mimetics)--preclinical and clinical results.

Journal: Best practice & research. Clinical endocrinology & metabolism 20090801

Title: Liraglutide in type 2 diabetes: from pharmacological development to clinical practice.

Journal: Acta bio-medica : Atenei Parmensis 20090801

Title: Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).

Journal: Lancet (London, England) 20090704

Title: GLP-1 receptor agonists for type 2 diabetes.

Journal: Lancet (London, England) 20090704

Title: Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD).

Journal: Diabetes care 20090701

Title: GLP-1 receptor agonists: targeting both hyperglycaemia and disease processes in diabetes.

Journal: Diabetes research and clinical practice 20090701

Title: [Drug therapy of type 2 diabetes and cardiovascular prevention: potentials for liraglutide].

Journal: Giornale italiano di cardiologia (2006) 20090701

Title: Glucagon-like peptide-1 receptor agonists in type 2 diabetes: a meta-analysis of randomized clinical trials.

Journal: European journal of endocrinology 20090601

Title: Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide.

Journal: Endocrinology 20090501

Title: Adding liraglutide to oral antidiabetic drug monotherapy: efficacy and weight benefits.

Journal: Postgraduate medicine 20090501

Title: Insights from the Liraglutide Clinical Development Program--the Liraglutide Effect and Action in Diabetes (LEAD) studies.

Journal: Postgraduate medicine 20090501

Title: [Incretin related agents for treatment of diabetes mellitus].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20090410

Title: A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules.

Journal: The Journal of endocrinology 20090401

Title: GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice.

Journal: Diabetes 20090401

Title: Diabetes treatment and measures of glycemia.

Journal: Diabetes care 20090401

Title: Treatment of type 2 diabetes with incretin-based therapies.

Journal: Lancet (London, England) 20090207

Title: Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial.

Journal: Lancet (London, England) 20090207

Title: Liraglutide: a new treatment for type 2 diabetes.

Journal: Drugs of today (Barcelona, Spain : 1998) 20090201

Title: Molecular, pharmacological and clinical aspects of liraglutide, a once-daily human GLP-1 analogue.

Journal: Molecular and cellular endocrinology 20090115

Title: Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study.

Journal: Diabetes care 20090101

Title: Incretin mimetics and DPP-4 inhibitors: new approach to treatment of type 2 diabetes mellitus.

Journal: Mymensingh medical journal : MMJ 20090101

Title: Long-term outcomes in patients with type 2 diabetes receiving glimepiride combined with liraglutide or rosiglitazone.

Journal: Cardiovascular diabetology 20090101

Title: Potential of liraglutide in the treatment of patients with type 2 diabetes.

Journal: Vascular health and risk management 20090101

Title: Lack of cardioprotection from subcutaneously and preischemic administered liraglutide in a closed chest porcine ischemia reperfusion model.

Journal: BMC cardiovascular disorders 20090101

Title: Incretin-based therapies: a new potential treatment approach to overcome clinical inertia in type 2 diabetes.

Journal: Acta bio-medica : Atenei Parmensis 20081201

Title: Combination pharmacotherapy with incretins: what works best and when?

Journal: Current diabetes reports 20081001

Title: Liraglutide, a long-acting human glucagon-like peptide 1 analog, improves glucose homeostasis in marginal mass islet transplantation in mice.

Journal: Endocrinology 20080901

Title: Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20080901

Title: Dose-dependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: A double-blind, randomized, controlled trial in Japanese patients with type 2 diabetes.

Journal: Diabetes research and clinical practice 20080801

Title: The once-daily human GLP-1 analog, liraglutide, reduces olanzapine-induced weight gain and glucose intolerance.

Journal: Schizophrenia research 20080801

Title: Patient-reported rating of gastrointestinal adverse effects during treatment of type 2 diabetes with the once-daily human GLP-1 analogue, liraglutide.

Journal: Diabetes, obesity & metabolism 20080701

Title: Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials.

Journal: Current opinion in clinical nutrition and metabolic care 20080701

Title: Exploiting the antidiabetic properties of incretins to treat type 2 diabetes mellitus: glucagon-like peptide 1 receptor agonists or insulin for patients with inadequate glycemic control?

Journal: European journal of endocrinology 20080601

Title: Tolerability, pharmacokinetics and pharmacodynamics of the once-daily human GLP-1 analog liraglutide in Japanese healthy subjects: a randomized, double-blind, placebo-controlled dose-escalation study.

Journal: International journal of clinical pharmacology and therapeutics 20080601

Title: Emerging incretin based therapies for type 2 diabetes: incretin mimetics and DPP-4 inhibitors.

Journal: Current diabetes reviews 20080501

Title: Combination of the insulin sensitizer, pioglitazone, and the long-acting GLP-1 human analog, liraglutide, exerts potent synergistic glucose-lowering efficacy in severely diabetic ZDF rats.

Journal: Diabetes, obesity & metabolism 20080401

Title: Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20080201

Title: Long-acting GLP-1 analogs for the treatment of type 2 diabetes mellitus.

Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20080101

Title: Incretin hormone mimetics and analogues in diabetes therapeutics.

Journal: Best practice & research. Clinical endocrinology & metabolism 20071201

Title: Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness.

Journal: Journal of medicinal chemistry 20071129

Title: GLP-1-based therapy of type 2 diabetes: GLP-1 mimetics and DPP-IV inhibitors.

Journal: Current diabetes reports 20071001

Title: Using prandial insulin to achieve glycemic control in type 2 diabetes.

Journal: The Journal of family practice 20070901

Title: Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions.

Journal: Diabetes care 20070801

Title: Incretins and their role in the management of diabetes.

Journal: Current opinion in endocrinology, diabetes, and obesity 20070801

Title: Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis.

Journal: JAMA 20070711

Title: [New concepts in the treatment of type 2 diabetes].

Journal: Der Internist 20070701

Title: Liraglutide, a once-daily human glucagon-like peptide-1 analog, minimizes food intake in severely obese minipigs.

Journal: Obesity (Silver Spring, Md.) 20070701

Title: Safety and adverse effects associated with GLP-1 analogues.

Journal: Expert opinion on drug safety 20070701

Title: [Glucagon-like peptide 1 (GLP-1)].

Journal: MMW Fortschritte der Medizin 20070621

Title: Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes.

Journal: Diabetes care 20070601

Title: Application of incretin mimetics and dipeptidyl peptidase IV inhibitors in managing type 2 diabetes mellitus.

Journal: The Journal of the American Osteopathic Association 20070501

Title: [Glucagon-like peptide-1 (GLP-1), new target for the treatment of type 2 diabetes].

Journal: Revue medicale de Liege 20070401

Title: Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus.

Journal: Expert opinion on investigational drugs 20070201

Title: Adapting the GLP-1-signaling system to the treatment of type 2 diabetes.

Journal: Current diabetes reviews 20070201

Title: Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not.

Journal: Diabetes 20070101

Title: Emerging treatments for patients with type 2 diabetes.

Journal: The Diabetes educator 20070101

Title: New therapies for diabetes.

Journal: Clinical cornerstone 20070101

Title: The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.

Journal: Lancet (London, England) 20061111

Title: How do different GLP-1 mimetics differ in their actions?

Journal: Current diabetes reports 20061101

Title: Gut hormones and related concepts.

Journal: Diabetes care 20061001

Title: Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20060901

Title: Investigational treatments for Type 2 diabetes mellitus: exenatide and liraglutide.

Journal: Expert opinion on investigational drugs 20060801

Title: American Diabetes Association--66th scientific sessions. 9-13 June 2006, Washington, DC, USA.

Journal: IDrugs : the investigational drugs journal 20060801

Title: New diabetes drugs target gut hormones.

Journal: JAMA 20060726

Title: An open-label, parallel group study investigating the effects of age and gender on the pharmacokinetics of the once-daily glucagon-like peptide-1 analogue liraglutide.

Journal: Journal of clinical pharmacology 20060601

Title: Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.

Journal: The Journal of endocrinology 20060301

Title: Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus.

Journal: The international journal of biochemistry & cell biology 20060101

Title: Incretins: what does the future hold?

Journal: Diabetes technology & therapeutics 20051001

Title: Biotechnology - 12th European Congress.

Journal: IDrugs : the investigational drugs journal 20051001

Title: Effects of liraglutide (NN2211), a long-acting GLP-1 analogue, on glycaemic control and bodyweight in subjects with Type 2 diabetes.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20050801

Title: The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro.

Journal: Biochemical and biophysical research communications 20050506

Title: [Targeting--a new way to identify unknown tumor markers in blood vessels].

Journal: Lakartidningen 20050201

Title: Incretin mimetics as emerging treatments for type 2 diabetes.

Journal: The Annals of pharmacotherapy 20050101

Title: The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes.

Journal: Diabetes care 20040801

Title: Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial.

Journal: Diabetes care 20040601

Title: GLP-1: target for a new class of antidiabetic agents?

Journal: Journal of the Royal Society of Medicine 20040601

Title: One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.

Journal: Diabetes 20040501

Title: Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors.

Journal: Expert opinion on emerging drugs 20040501

Title: Potential therapies mimicking the effects of glucagon-like peptide-1 for the treatment of type 2 diabetes.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20040101

Title: The endocrine pancreas in non-diabetic rats after short-term and long-term treatment with the long-acting GLP-1 derivative NN2211.

Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20031201

Title: The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose.

Journal: Diabetes 20030701

Title: Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030601

Title: NN-2211 Novo Nordisk.

Journal: IDrugs : the investigational drugs journal 20030301

Title: The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice.

Journal: American journal of physiology. Endocrinology and metabolism 20021001

Title: NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.

Journal: European journal of pharmacology 20020913

Title: Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects.

Journal: Diabetes care 20020801

Title: Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes.

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Title: IMPAN cells: a pancreatic model for differentiation into endocrine cells.

Journal: Archives of biochemistry and biophysics 20011115

Title: Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats.

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Title: Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.

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Tags:204656-20-2 Molecular Formula|204656-20-2 MDL|204656-20-2 SMILES|204656-20-2 Liraglutide