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502632-66-8,MFCD11840616
Catalog No.:AA00DA8M

502632-66-8 | Px-866

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Purity
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Price(USD)
Quantity
  
1mg
≥95%
in stock  
$105.00   $73.00
- +
5mg
≥95%
in stock  
$438.00   $306.00
- +
10mg
≥95%
in stock  
$718.00   $502.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DA8M
Chemical Name:
Px-866
CAS Number:
502632-66-8
Molecular Formula:
C29H35NO8
Molecular Weight:
525.5901
MDL Number:
MFCD11840616
SMILES:
COC[C@H]1OC(=O)/C(=C/N(CC=C)CC=C)/C2=C(C(=O)C3=C([C@@]12C)[C@H](OC(=O)C)C[C@]1([C@H]3CCC1=O)C)O
Properties
Computed Properties
 
Complexity:
1200  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
9  
XLogP3:
1.7  

Literature

Title: Akt activation by Ca(2+)/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells.

Journal: The Journal of biological chemistry 20170825

Title: Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice.

Journal: The Journal of biological chemistry 20150501

Title: A multicenter phase I trial of PX-866, an oral irreversible phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120801

Title: Role and therapeutic potential of PI3K-mTOR signaling in de novo resistance to BRAF inhibition.

Journal: Pigment cell & melanoma research 20120301

Title: Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma.

Journal: International journal of cancer 20110215

Title: Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma.

Journal: Neuro-oncology 20100601

Title: Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity.

Journal: Molecular cancer therapeutics 20090101

Title: Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy.

Journal: Journal of medicinal chemistry 20080313

Title: Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.

Journal: PloS one 20080101

Title: The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.

Journal: Molecular cancer therapeutics 20070901

Title: The skin and hair as surrogate tissues for measuring the target effect of inhibitors of phosphoinositide-3-kinase signaling.

Journal: Cancer chemotherapy and pharmacology 20061001

Title: The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts.

Journal: Molecular cancer therapeutics 20050901

Title: Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling.

Journal: Molecular cancer therapeutics 20040701

Title: Ihle NT, et al. The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growthfactor receptor inhibitor ZD1839 in A-549 human non-small cell lung cancer xenografts. Mol Cancer Ther. 2005 Sep;4(9):1349-57.

Title: Bowles DW, et al. A Randomized, Phase II Trial of C225 With or Without PX-866, an Irreversible Oral Phosphatidylinositol 3-Kinase Inhibitor, in Patients With Metastatic Colorectal Carcinoma. Clin Colorectal Cancer. 2016 Dec;15(4):337-344.e2.

Title: Sonolisib

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