457081-03-7,MFCD17019334
Catalog No.:AA00DANX

457081-03-7 | Pyridone 6

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$42.00   $29.00
- +
5mg
≥98%
in stock  
$135.00   $94.00
- +
10mg
≥98%
in stock  
$208.00   $145.00
- +
25mg
≥98%
in stock  
$363.00   $254.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DANX
Chemical Name:
Pyridone 6
CAS Number:
457081-03-7
Molecular Formula:
C18H16FN3O
Molecular Weight:
309.3375
MDL Number:
MFCD17019334
SMILES:
Fc1ccc2c(c1)c1c(=O)[nH]ccc1c1c2[nH]c(n1)C(C)(C)C
Properties
Properties
 
Form:
Solid  
MP:
>178°C (dec.)  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
529  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4  

Literature

Title: Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.

Journal: Nature communications 20140828

Title: Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.

Journal: Molecules (Basel, Switzerland) 20140808

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.

Journal: Bioorganic & medicinal chemistry 20120115

Title: Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20111101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma.

Journal: Biochemical and biophysical research communications 20110107

Title: CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes.

Journal: Arthritis research & therapy 20110101

Title: Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling.

Journal: Molecular and cellular endocrinology 20100830

Title: Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

Journal: Journal of molecular biology 20100716

Title: Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3.

Journal: Experimental cell research 20100401

Title: STAT3 signalling pathway is involved in the activation of microglia induced by 2.45 GHz electromagnetic fields.

Journal: International journal of radiation biology 20100101

Title: Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.

Journal: Journal of molecular biology 20090320

Title: Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression.

Journal: Biological & pharmaceutical bulletin 20090101

Title: Virtual screening to successfully identify novel janus kinase 3 inhibitors: a sequential focused screening approach.

Journal: Journal of medicinal chemistry 20081113

Title: Chemotherapy-induced toxic erythema under treatment with pegylated liposomal doxorubicin: No restriction to palms and soles.

Journal: Journal of the American Academy of Dermatology 20080201

Title: Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells.

Journal: BMC cancer 20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20071215

Title: Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.

Journal: Cancer research 20061001

Title: IL-4 induced MUC4 enhancement in respiratory epithelial cells in vitro is mediated through JAK-3 selective signaling.

Journal: Respiratory research 20060101

Title: Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway.

Journal: Molecular pharmacology 20040801

Title: Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20020422

Title: Thompson JE, et al. Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23.

Title: Nakagawa R, et al. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J Immunol. 2011 Nov 1;187(9):4611-20.

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SDS
Related Products of 457081-03-7
Tags:457081-03-7 Molecular Formula|457081-03-7 MDL|457081-03-7 SMILES|457081-03-7 Pyridone 6
Catalog No.: AA00DANX
457081-03-7,MFCD17019334
457081-03-7 | Pyridone 6
Pack Size: 1mg
Purity: ≥98%
in stock
$42.00 $29.00
Pack Size: 5mg
Purity: ≥98%
in stock
$135.00 $94.00
Pack Size: 10mg
Purity: ≥98%
in stock
$208.00 $145.00
Pack Size: 25mg
Purity: ≥98%
in stock
$363.00 $254.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00DANX
Chemical Name: Pyridone 6
CAS Number: 457081-03-7
Molecular Formula: C18H16FN3O
Molecular Weight: 309.3375
MDL Number: MFCD17019334
SMILES: Fc1ccc2c(c1)c1c(=O)[nH]ccc1c1c2[nH]c(n1)C(C)(C)C
Properties
Form: Solid  
MP: >178°C (dec.)  
Storage: -20 ℃;  
Complexity: 529  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4  
Literature fold

Title: Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.

Journal: Nature communications20140828

Title: Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway.

Journal: Molecules (Basel, Switzerland)20140808

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells.

Journal: Bioorganic & medicinal chemistry20120115

Title: Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17.

Journal: Journal of immunology (Baltimore, Md. : 1950)20111101

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma.

Journal: Biochemical and biophysical research communications20110107

Title: CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes.

Journal: Arthritis research & therapy20110101

Title: Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling.

Journal: Molecular and cellular endocrinology20100830

Title: Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

Journal: Journal of molecular biology20100716

Title: Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3.

Journal: Experimental cell research20100401

Title: STAT3 signalling pathway is involved in the activation of microglia induced by 2.45 GHz electromagnetic fields.

Journal: International journal of radiation biology20100101

Title: Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains.

Journal: Journal of molecular biology20090320

Title: Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression.

Journal: Biological & pharmaceutical bulletin20090101

Title: Virtual screening to successfully identify novel janus kinase 3 inhibitors: a sequential focused screening approach.

Journal: Journal of medicinal chemistry20081113

Title: Chemotherapy-induced toxic erythema under treatment with pegylated liposomal doxorubicin: No restriction to palms and soles.

Journal: Journal of the American Academy of Dermatology20080201

Title: Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells.

Journal: BMC cancer20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America20071218

Title: Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.

Journal: Bioorganic & medicinal chemistry letters20071215

Title: Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.

Journal: Cancer research20061001

Title: IL-4 induced MUC4 enhancement in respiratory epithelial cells in vitro is mediated through JAK-3 selective signaling.

Journal: Respiratory research20060101

Title: Tumor necrosis factor-alpha differentially regulates the expression of proinflammatory genes in human airway smooth muscle cells by activation of interferon-beta-dependent CD38 pathway.

Journal: Molecular pharmacology20040801

Title: Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor.

Journal: Bioorganic & medicinal chemistry letters20020422

Title: Thompson JE, et al. Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1219-23.

Title: Nakagawa R, et al. Pyridone 6, a pan-JAK inhibitor, ameliorates allergic skin inflammation of NC/Nga mice via suppression of Th2 and enhancement of Th17. J Immunol. 2011 Nov 1;187(9):4611-20.

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