Name: Name:MK-0752
Brand: AABLOCKS
SKU: AA00DB40
Rating: 90 (10 reviews)

Catalog No.: AA00DB40

471905-41-6 | MK-0752

Pack Size： 1mg

Purity： ≥98%

in stock

$98.00 $68.00

Pack Size： 5mg

Purity： 98% by HPLC

in stock

$224.00 $157.00

Pack Size： 100mg

Purity： 95%

in stock

$270.00 $189.00

Pack Size： 250mg

Purity： 95%

in stock

$446.00 $312.00

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Technical Information

Catalog Number: AA00DB40

Chemical Name: MK-0752

CAS Number: 471905-41-6

Molecular Formula: C21H21ClF2O4S

Molecular Weight: 442.9038

MDL Number: MFCD21608529

SMILES: OC(=O)CC[C@@H]1CC[C@](CC1)(c1cc(F)ccc1F)S(=O)(=O)c1ccc(cc1)Cl

Properties

Complexity: 665

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 29

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 1

Rotatable Bond Count: 6

XLogP3: 4.7

Downstream Synthesis Route

656810-86-5

471905-41-6

[1]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

942296-40-4

471905-41-6

trans-3-4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexylpropanoicacid

[1]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

863605-38-3

471905-41-6

[1]JournalofOrganicChemistry,2007,vol.72,p.4864-4871

470716-52-0

471905-41-6

[1]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

[2]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

[3]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

[4]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

470716-51-9

471905-41-6

[1]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

[2]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

[3]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

[4]JournalofOrganicChemistry,2007,vol.72,p.4149-4155

Literature fold

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20110910

Title: Determination of the gamma-secretase inhibitor MK-0752 in human plasma by online extraction and electrospray tandem mass spectrometry (HTLC-ESI-MS/MS).

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20100901

Title: Determination of a novel gamma-secretase inhibitor in human plasma and cerebrospinal fluid using automated 96 well solid phase extraction and liquid chromatography/tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20080215

Title: Cook JJ, et al. Acute gamma-secretase inhibition of nonhuman primate CNS shifts amyloid precursor protein (APP) metabolism from amyloid-beta production to alternative APP fragments without amyloid-beta rebound. J Neurosci. 2010;30(19):6743-6750.

Title: Krop I, et al. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012;30(19):2307-2313.