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530141-72-1,MFCD08272618
Catalog No.:AA00DB4U

530141-72-1 | Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-

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1mg
98%
in stock  
$21.00   $15.00
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5mg
98%
in stock  
$50.00   $35.00
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10mg
98%
in stock  
$74.00   $52.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DB4U
Chemical Name:
Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-
CAS Number:
530141-72-1
Molecular Formula:
C29H27NO8
Molecular Weight:
517.5266
MDL Number:
MFCD08272618
SMILES:
OC(=O)CCc1cc(ccc1OCc1ccc2c(c1)o[nH]c2=O)C(=O)c1ccc(cc1O)OC1CCCC1
Properties
Computed Properties
 
Complexity:
844  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
10  
XLogP3:
5.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:NNAJINGHAOLVTECH-CN109020912,2018,A

[1]CurrentPatentAssignee:NNAJINGHAOLVTECH-CN109020912,2018,A

[1]CurrentPatentAssignee:NNAJINGHAOLVTECH-CN109020912,2018,A

6342-77-4   
T-5224 

[1]Patent:CN109020912,2018,A

[1]CurrentPatentAssignee:NNAJINGHAOLVTECH-CN109020912,2018,A

Literature

Title: Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

Journal: Arthritis and rheumatism 20120501

Title: Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110501

Title: Makino H, et al. A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebraldisc degeneration and associated pain. Sci Rep. 2017 Dec 5;7(1):16983.

Title: Aikawa Y, et al. Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol. 2008 Jul;26(7):817-23.

Title: Kamide D, et al. Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model. Cancer Sci.?2016 May;107(5):666-73.

Title: Izuta S, et al. T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice. Biotechnol Lett. 2012 Dec;34(12):2175-82.

Title: Uchihashi S, et al. Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Drug Metab Dispos. 2011 May;39(5):803-13.

Title: Miyazaki H, et al. The effects of a selective inhibitor of c-Fos/activator protein-1 on endotoxin-induced acute kidney injury in mice. BMC Nephrol. 2012 Nov 23;13:153.

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SDS
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Tags:530141-72-1 Molecular Formula|530141-72-1 MDL|530141-72-1 SMILES|530141-72-1 Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-