Name: Name:Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-
Brand: AABLOCKS
SKU: AA00DB4U
Rating: 90 (10 reviews)

Catalog No.: AA00DB4U

530141-72-1 | Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-

Pack Size： 1mg

Purity： 98%

in stock

$21.00 $15.00

Pack Size： 5mg

Purity： 98%

in stock

$50.00 $35.00

Pack Size： 10mg

Purity： 98%

in stock

$75.00 $53.00

Pack Size： 250mg

Purity： 95%

in stock

$1,479.00 $1,035.00

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Technical Information

Catalog Number: AA00DB4U

Chemical Name: Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-

CAS Number: 530141-72-1

Molecular Formula: C29H27NO8

Molecular Weight: 517.5266

MDL Number: MFCD08272618

SMILES: OC(=O)CCc1cc(ccc1OCc1ccc2c(c1)o[nH]c2=O)C(=O)c1ccc(cc1O)OC1CCCC1

Properties

Complexity: 844

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 38

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 10

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 5.1

Downstream Synthesis Route

374893-27-3

530141-72-1

[1]CurrentPatentAssignee:NNAJINGHAOLVTECH-CN109020912,2018,A

530141-56-1

530141-72-1

[1]CurrentPatentAssignee:NNAJINGHAOLVTECH-CN109020912,2018,A

530141-58-3

530141-72-1

[1]CurrentPatentAssignee:NNAJINGHAOLVTECH-CN109020912,2018,A

6342-77-4

T-5224

[1]Patent:CN109020912,2018,A

1714088-38-6

530141-72-1

[1]CurrentPatentAssignee:NNAJINGHAOLVTECH-CN109020912,2018,A

Literature fold

Title: Inhibition of activator protein 1 signaling abrogates transforming growth factor β-mediated activation of fibroblasts and prevents experimental fibrosis.

Journal: Arthritis and rheumatism20120501

Title: Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms.

Journal: Drug metabolism and disposition: the biological fate of chemicals20110501

Title: Makino H, et al. A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebraldisc degeneration and associated pain. Sci Rep. 2017 Dec 5;7(1):16983.

Title: Aikawa Y, et al. Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol. 2008 Jul;26(7):817-23.

Title: Kamide D, et al. Selective activator protein-1 inhibitor T-5224 prevents lymph node metastasis in an oral cancer model. Cancer Sci.?2016 May;107(5):666-73.

Title: Izuta S, et al. T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice. Biotechnol Lett. 2012 Dec;34(12):2175-82.

Title: Uchihashi S, et al. Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Drug Metab Dispos. 2011 May;39(5):803-13.

Title: Miyazaki H, et al. The effects of a selective inhibitor of c-Fos/activator protein-1 on endotoxin-induced acute kidney injury in mice. BMC Nephrol. 2012 Nov 23;13:153.

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