Name: Name:Methyl protodioscin
Brand: AABLOCKS
SKU: AA00DB66
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00DB66

Chemical Name: Methyl protodioscin

CAS Number: 54522-52-0

Molecular Formula: C52H86O22

Molecular Weight: 1063.2260

MDL Number: MFCD30478892

SMILES: OC[C@H]1O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@H](C)[C@@](O4)(OC)CC[C@H](CO[C@@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O)C)C)C2)C)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O

Properties

Complexity: 1920

Covalently-Bonded Unit Count: 1

Heavy Atom Count: 74

Hydrogen Bond Acceptor Count: 22

Hydrogen Bond Donor Count: 12

Rotatable Bond Count: 15

Undefined Atom Stereocenter Count: 31

XLogP3: -0.7

Literature fold

Title: Pharmacokinetics of methyl protodioscin in rats.

Journal: Die Pharmazie20100501

Title: [Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine20100401

Title: [Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20100101

Title: New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.

Journal: Biomedical chromatography : BMC20090101

Title: [Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20080601

Title: Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study.

Journal: Biomedical chromatography : BMC20080401

Title: Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.

Journal: Analytica chimica acta20070905

Title: Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.

Journal: Cancer letters20060908

Title: Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.

Journal: Steroids20060901

Title: Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.

Journal: The Journal of steroid biochemistry and molecular biology20060701

Title: Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.

Journal: Organic letters20060622

Title: [Study on chemical constituents in total saponin from Trigonella foenum-graecum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20050901

Title: Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.

Journal: Cancer letters20050628

Title: In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.

Journal: Planta medica20040301

Title: The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.

Journal: Cancer investigation20030601

Title: Total synthesis of methyl protodioscin: a potent agent with antitumor activity.

Journal: The Journal of organic chemistry20030502

Title: Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.

Journal: Biological & pharmaceutical bulletin20010201

Title: Bai Y, et al. Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells. Pharmacogn Mag. 2014 Jul;10(39):318-24.

Title: Ma W, et al. Methyl protodioscin increases ABCA1 expression and cholesterol efflux while inhibiting gene expressions for synthesis of cholesterol and triglycerides by suppressing SREBP transcription and microRNA 33a/b levels. Atherosclerosis. 2015 Apr;239(2):566-70.

54522-52-0 | Methyl protodioscin