Home Other Building Blocks 510-30-5
510-30-5,MFCD00017295
Catalog No.:AA00DB7R

510-30-5 | Echinocystic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$7.00   $5.00
- +
5mg
97%
in stock  
$21.00   $15.00
- +
10mg
97%
in stock  
$31.00   $22.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00DB7R
Chemical Name:
Echinocystic acid
CAS Number:
510-30-5
Molecular Formula:
C30H48O4
Molecular Weight:
472.6997
MDL Number:
MFCD00017295
SMILES:
O[C@@H]1C[C@]2(C)C(=CC[C@H]3[C@@]2(C)CCC2[C@]3(C)CC[C@@H](C2(C)C)O)[C@@H]2[C@@]1(CCC(C2)(C)C)C(=O)O
Properties
Computed Properties
 
Complexity:
919  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
6.9  

Downstream Synthesis Route

[1]Bergsteinsson;Noller[JournaloftheAmericanChemicalSociety,1934,vol.56,p.1403,1405]

[2]Konoshima,Takao;Fukushima,Hiroyuki;Inui,Hideo;Sato,Keiko;Sawada,Tokunosuke[Phytochemistry,1981,vol.20,p.139-142]

[3]Varshney,I.P.;Jain,D.C.;Srivastava,H.C.[JournaloftheIndianChemicalSociety,1982,vol.59,#7,p.884-887]Akoi,Tadashi;Shido,Kazumi;Takahashi,Yutaka;Suga,Takayuki[Phytochemistry,1981,vol.20,#7,p.1681-1686]

[4]Shao,Yu;Poobrasert,Onoomar;Ho,Chi-Tang;Chin,Chee-Kok;Cordell,GeoffreyA.[Phytochemistry,1996,vol.43,#1,p.195-200]

510-30-5   
17α-H-18β-H-28-norolean-12-ene-3,16-dione 

[1]Bilham;Kon[JournaloftheChemicalSociety,1941,p.552,559]White;Noller[JournaloftheAmericanChemicalSociety,1939,vol.61,p.983,988]

[2]Zhou,Meng;Wang,Min;Zhong,Rui-Feng;Liao,Xiang-Ming;Deng,Lian-Li;Xu,Guo-Bo;He,Xun;Li,Jing;Li,Yong-Jun;Liu,Ting;Wang,Yong-Lin;Liao,Shang-Gao[BioorganicandMedicinalChemistryLetters,2017,vol.27,#16,p.3636-3642]

[1]CurrentPatentAssignee:JILINACADOFTRADITIONALCHINESEMEDICINESCIENCE-CN109206470,2019,ALocationinpatent:Paragraph0045-0047

[2]Jeger;Nisoli;Reichstein[HelveticaChimicaActa,1946,vol.29,p.1183,1191]Bergsteinsson;Noller[JournaloftheAmericanChemicalSociety,1934,vol.56,p.1403,1405]

gleditsiosideD 
  510-30-5 

[1]Zhang,Zhizhen;Koike,Kazuo;Jia,Zhonghua;Nikaido,Tamotsu;Guo,Dean;Zheng,Junhua[JournalofNaturalProducts,1999,vol.62,#5,p.740-745]

Literature

Title: Synthesis and anti-HCV entry activity studies of β-cyclodextrin-pentacyclic triterpene conjugates.

Journal: ChemMedChem 20140501

Title: Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.

Journal: Journal of medicinal chemistry 20130613

Title: Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-κB and MAPK pathways.

Journal: Biochemical pharmacology 20120801

Title: Echinocystic acid 3,16-O-bisglycosides from Albizia procera.

Journal: Phytochemistry 20100801

Title: Murine metabolism and absorption of lancemaside A, an active compound in the roots of Codonopsis lanceolata.

Journal: Journal of natural medicines 20100701

Title: A sensitive liquid chromatography-electrospray tandem mass spectrometric method for lancemaside A and its metabolites in plasma and a pharmacokinetic study in mice.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100701

Title: Triterpene glycosides from Agrostemma gracilis.

Journal: Phytochemistry 20100401

Title: Protective effects of echinocystic acid isolated from Gleditsia sinensis Lam. against acute myocardial ischemia.

Journal: Fitoterapia 20100101

Title: The interleukin-18 inhibitory activities of echinocystic acid and its saponins from Impatiens pritzellii var. hupehensis.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

Title: Immunomodulatory effects of two sapogenins 1 and 2 isolated from Luffa cylindrica in Balb/C mice.

Journal: Bioorganic & medicinal chemistry letters 20070315

Title: Beta-D-xylopyranosyl-(1-->3)-beta-D-glucuronopyranosyl echinocystic acid isolated from the roots of Codonopsis lanceolata induces caspase-dependent apoptosis in human acute promyelocytic leukemia HL-60 cells.

Journal: Biological & pharmaceutical bulletin 20050501

Title: Molecular mechanisms of echinocystic acid-induced apoptosis in HepG2 cells.

Journal: Biochemical and biophysical research communications 20040827

Title: Echinocystic acid induces apoptosis in HL-60 cells through mitochondria-mediated death pathway.

Journal: Cancer letters 20040820

Title: A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.

Journal: Mini reviews in medicinal chemistry 20030901

Title: Bioactive saponins from Acacia tenuifolia from the suriname rainforest.

Journal: Journal of natural products 20020201

Title: Anti-AIDS agents, 21. Triterpenoid saponins as anti-HIV principles from fruits of Gleditsia japonica and Gymnocladus chinensis, and a structure-activity correlation.

Journal: Journal of natural products 19950901

Title: Yang JH et al. Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways. Biochem Biophys Res Commun. 2016 Sep 2;477(4):673-7.

Title: Ma Z et al. Echinocystic Acid Inhibits IL-1β-Induced COX-2 and iNOS Expression in Human Osteoarthritis Chondrocytes. Inflammation. 2016 Apr;39(2):543-9.

Title: Li S et al. Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. Metab Brain Dis. 2016 Apr;31(2):455-63.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:510-30-5 Molecular Formula|510-30-5 MDL|510-30-5 SMILES|510-30-5 Echinocystic acid