Title: Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase.
Journal: Journal of medicinal chemistry 20110414
Title: Some aspects of the reproductive endocrinology of the stallion and cryptorchid.
Journal: Journal of reproduction and fertility. Supplement 19751001
Title: Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2--hydroxy-1-(2-hydroxyethyl)propylamino-8-methyl-8H-pyrido,3-dpyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido,3-dpyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65.
