Home Other Building Blocks 47141-42-4
47141-42-4,MFCD00864586
Catalog No.:AA00DC9P

47141-42-4 | LEVOBUNOLOL

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
2 weeks  
$1,817.00   $1,272.00
- +
1.25g
2 weeks  
$3,327.00   $2,329.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00DC9P
Chemical Name:
LEVOBUNOLOL
CAS Number:
47141-42-4
Molecular Formula:
C17H25NO3
Molecular Weight:
291.3853
MDL Number:
MFCD00864586
SMILES:
CC(C)(C)NCC(COC1=CC=CC2=C1CCCC2=O)O
Properties
Computed Properties
 
Complexity:
350  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2.4  

Literature

Title: Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis.

Journal: Chemical research in toxicology 20150518

Title: Ocular hypotensive effect and safety of travoprost 0.004%/timolol maleate 0.5% fixed combination after change of treatment regimen from β-blockers and prostaglandin analogs.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Effects of anti-glaucoma drugs on resistive index of the medial long posterior ciliary artery using color Doppler imaging in Beagle dogs.

Journal: Journal of veterinary science 20110301

Title: Development of novel in silico model to predict corneal permeability for congeneric drugs: a QSPR approach.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Short-term effect of topical antiglaucoma medication on tear-film stability, tear secretion, and corneal sensitivity in healthy subjects.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20110101

Title: Effects of benzalkonium chloride- or polyquad-preserved fixed combination glaucoma medications on human trabecular meshwork cells.

Journal: Molecular vision 20110101

Title: A new mode of dimerization of allosteric enzymes with ACT domains revealed by the crystal structure of the aspartate kinase from Cyanobacteria.

Journal: Journal of molecular biology 20100604

Title: Efficacy and patient tolerability of travoprost BAK-free solution in patients with open-angle glaucoma and ocular hypertension.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20100101

Title: Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma.

Journal: Veterinary therapeutics : research in applied veterinary medicine 20100101

Title: Comparison of effects of topical levobunolol to a combination of timolol-dorzolamide on intraocular pressure and pulse rate of healthy dogs.

Journal: Veterinary research communications 20090901

Title: Retrospective cohort study of 163 pediatric glaucoma patients.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20090601

Title: [Cytotoxicity of antiglaucoma ophthalmic solutions for human corneal endothelial cells].

Journal: Nippon Ganka Gakkai zasshi 20090501

Title: Poly (epsilon-caprolactone) microparticles containing Levobunolol HCl prepared by a multiple emulsion (W/O/W) solvent evaporation technique: effects of some formulation parameters on microparticle characteristics.

Journal: Journal of microencapsulation 20090201

Title: Effect of latanoprost and timolol on the histopathology of the human conjunctiva.

Journal: The British journal of ophthalmology 20090201

Title: Oral versus topical carbonic anhydrase inhibitors in ocular hypertension after scleral tunnel cataract surgery.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20090101

Title: Aerobic exercise and intraocular pressure in normotensive and glaucoma patients.

Journal: BMC ophthalmology 20090101

Title: Recent advances in pharmacotherapy of glaucoma.

Journal: Indian journal of pharmacology 20081001

Title: Miscellaneous.

Journal: Indian journal of pharmacology 20081001

Title: An in vivo confocal microscopy and impression cytology analysis of preserved and unpreserved levobunolol-induced conjunctival changes.

Journal: European journal of ophthalmology 20080101

Title: Vasodilatory mechanism of levobunolol on vascular smooth muscle cells.

Journal: Experimental eye research 20070601

Title: Levobetaxolol hydrochloride: a review of its pharmacology and use in the treatment of chronic open-angle glaucoma and ocular hypertension.

Journal: Clinical ophthalmology (Auckland, N.Z.) 20070601

Title: Cellular cytotoxicity of antiglaucoma drugs in cultured corneal endothelial cells.

Journal: The Kaohsiung journal of medical sciences 20070301

Title: Allergic contact dermatitis due to levobunolol with cross-sensitivity to befunolol.

Journal: Contact dermatitis 20070101

Title: Myocilin mutations among primary open angle glaucoma patients of Kanyakumari district, South India.

Journal: Molecular vision 20070101

Title: Membrane electrodes for determination of some beta-blocker drugs.

Journal: Journal of AOAC International 20070101

Title: Daily cost of glaucoma medications in China.

Journal: Journal of glaucoma 20070101

Title: Contact dermatitis to levobunolol eyedrops superimposed on IgE-mediated rhinoconjunctivitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061201

Title: Drops and falls.

Journal: Age and ageing 20061101

Title: Allergic contact dermatitis due to levobunolol in an ophthalmic preparation.

Journal: The Journal of dermatology 20060701

Title: The management of glaucoma and intraocular hypertension: current approaches and recent advances.

Journal: Therapeutics and clinical risk management 20060601

Title: Transdermal delivery of beta-blockers.

Journal: Expert opinion on drug delivery 20060501

Title: Beta-blocker eye drops.

Journal: Nursing times 20060501

Title: Effects of antiglaucoma drugs on cellular proliferation in cultured human corneal keratocytes.

Journal: The Kaohsiung journal of medical sciences 20060301

Title: Effects of antiglaucoma drugs on calcium mobility in cultured corneal endothelial cells.

Journal: The Kaohsiung journal of medical sciences 20060201

Title: Allergic contact dermatitis due to beta-blockers in eye drops: a retrospective analysis of multicentre surveillance data 1993-2004.

Journal: Acta dermato-venereologica 20060101

Title: Carteolol hydrochloride protects human corneal epithelial cells from UVB-induced damage in vitro.

Journal: Cornea 20050301

Title: The effect of once-daily levobunolol on intraocular pressure in normal-tension glaucoma.

Journal: Japanese journal of ophthalmology 20050101

Title: Study of effects of antiglaucoma eye drops on N-methyl-D-aspartate-induced retinal damage.

Journal: Japanese journal of ophthalmology 20050101

Title: Reversal of disc cupping after intraocular pressure reduction in topographic image series.

Journal: Journal of glaucoma 20041001

Title: [Cost-effectivity analysis of the most used antiglaucoma drugs].

Journal: Archivos de la Sociedad Espanola de Oftalmologia 20040801

Title: Inhibition of endothelin-1 and KCL-induced increase of [CA2+]i by antiglaucoma drugs in cultured A7r5 vascular smooth-muscle cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601

Title: Effects of carteolol hydrochloride on the in vitro production of LPS-induced proinflammatory cytokines by murine macrophage.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040601

Title: Deposits in artificial corneas: risk factors and prevention.

Journal: Clinical & experimental ophthalmology 20040401

Title: Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040401

Title: Stereoselectivity for interactions of agonists and antagonists at mouse, rat and human beta3-adrenoceptors.

Journal: European journal of pharmacology 20040126

Title: [Osmotic resistance of red blood cells membranes in Vermox and 'AKbeta' vitamin complex treatment of experimental trichinosis in rats].

Journal: Wiadomosci parazytologiczne 20040101

Title: Thyroid eye disease and glaucoma.

Journal: Journal of glaucoma 20031201

Title: Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.

Journal: Cornea 20031101

Title: Bilateral nongranulomatous anterior uveitis associated with bimatoprost.

Journal: Journal of cataract and refractive surgery 20031101

Title: Metipranolol attenuates lipid peroxidation in rat brain: a comparative study with other antiglaucoma drugs.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20031001

Title: Medical therapy cost considerations for glaucoma.

Journal: American journal of ophthalmology 20030701

Title: The effect of topical glaucoma medications evaluated by perimetry.

Journal: The British journal of ophthalmology 20030601

Title: Noninvasive assessment of aqueous humor turnover in the mouse eye.

Journal: Investigative ophthalmology & visual science 20030201

Title: Cost analysis of glaucoma medications: a 3-year review.

Journal: Journal of glaucoma 20020801

Title: Spectrophotometric determination of beta-adrenergic blocking agents in pharmaceutical formulations.

Journal: Journal of pharmaceutical and biomedical analysis 20020701

Title: A comparison of the efficacy and tolerability of 0.5% timolol maleate ophthalmic gel-forming solution QD and 0.5% levobunolol hydrochloride BID in patients with ocular hypertension or open-angle glaucoma.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020401

Title: Allergic reactions to brimonidine in patients treated for glaucoma.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20020201

Title: Topical beta blockers and atrioventricular block in the elderly.

Journal: Journal of postgraduate medicine 20020101

Title: Commercially available ocular hypotensive products: preservative concentration, stability, storage, and in-life utilization.

Journal: Journal of glaucoma 20011201

Title: Contact dermatitis to topical drugs for glaucoma.

Journal: American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20011201

Title: Timolol may inhibit aqueous humor secretion by cAMP-independent action on ciliary epithelial cells.

Journal: American journal of physiology. Cell physiology 20010901

Title: Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010801

Title: Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels.

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20010701

Title: False-negative patch test with levobunolol.

Journal: Contact dermatitis 20010401

Title: The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study.

Journal: European journal of ophthalmology 20010101

Title: Cardiovascular considerations in using topical, oral, and intravenous drugs for the treatment of glaucoma and ocular hypertension: focus on beta-adrenergic blockade.

Journal: Heart disease (Hagerstown, Md.) 20010101

Title: [Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers].

Journal: Nippon Ganka Gakkai zasshi 19990701

Title: Short-term effects of topical levobunolol on the human retinal circulation.

Journal: Eye (London, England) 19970101

Title: Syncope, bradycardia, and atrioventricular block associated with topical ophthalmic levobunolol.

Journal: American heart journal 19940301

Title: A comparison of the ocular hypotensive efficacy and systemic safety of 0.5% levobunolol and 2% carteolol.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 19940101

Title: A comparison of the ocular tolerability of a single dose of timolol and levobunolol in healthy normotensive volunteers.

Journal: Annals of ophthalmology 19930401

Title: Ocular levobunolol. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

Journal: Drugs 19871201

Title: Comparison of ophthalmic beta-blocking agents.

Journal: Clinical pharmacy 19870601

Title: Levobunolol for the long-term treatment of glaucoma.

Journal: General pharmacology 19860101

Title: l-Bunolol and propranolol: oral and intravenous beta-adrenoceptor blocking activity in rats compared to dogs and humans.

Journal: Journal of pharmaceutical sciences 19780101

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:47141-42-4 Molecular Formula|47141-42-4 MDL|47141-42-4 SMILES|47141-42-4 LEVOBUNOLOL